The group of Prof. Dr.-Ing. Laura De Laporte designs biomaterial systems for Advance Medical Systems in the field of Tissue Engineering. Cellular guidance is essential for life in multicellularity but it remains challenging to build biomaterial constructs with a native-like extracellular matrix structure and architecture, including spatiotemporal control over bio-functional domains and mechanical gradients. To study cellular processes involved in tissue formation and diseases, we apply polymeric molecular and nano- to micron-scale building blocks to assemble into soft 3D biomimetic constructs in a bottom-up manner. Hydrogels are designed with structural variations on different length scales, while the time scales have to be accounted for due to alterations upon the interaction with living cells. A better understanding of cellular processes depending on the properties and dynamics of synthetic biomaterials supplies information about the material parameters, which are most important to grow viable and functional regenerative materials for clinical use and ex vivo tissue models.
Prof. Dr.-Ing. Laura De Laporte
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Engineering Anisotropic Cell Models: Development of Collagen Hydrogel Scaffolds with Magneto-Responsive Peg Microgels for Tissue Engineering Applications
A. L. Castro, S. Vedaraman, T. Haraszti, M. A. Barbosa, R. M. Gonçalves and L. De Laporte
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https://doi.org/10.1002/admt.202301391 | Advanced Materials Technologies | 2024 | |
Varying the Stiffness and Diffusivity of Rod-Shaped Microgels Independently through Their Molecular Building Blocks
Y. Kittel, L. P. B. Guerzoni, C. Itzin, D. Rommel, M. Mork, C. Bastard, B. Häßel, A. Omidinia-Anarkoli, S. P. Centeno, T. Haraszti, K. Kim, J. Guck, A. J. C. Kuehne and L. De Laporte
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https://doi.org/10.1002/anie.202309779 | Angewandte Chemie International Edition | 2023 | |
Transformative Medical Materials
L. De Laporte and F. Kiessling
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https://doi.org/10.1002/adhm.202301637 | Advanced Healthcare Materials | 2023 | |
Transformative Materials to Create 3D Functional Human Tissue Models in Vitro in a Reproducible Manner
J. L. Gerardo-Nava, J. Jansen, D. Günther, L. Klasen, A. L. Thiebes, B. Niessing, C. Bergerbit, A. A. Meyer, J. Linkhorst, M. Barth, P. Akhyari, J. Stingl, S. Nagel, T. Stiehl, A. Lampert, R. Leube, M. Wessling, F. Santoro, S. Ingebrandt, S. Jockenhoevel, A. Herrmann, H. Fischer, W. Wagner, R. H. Schmitt, F. Kiessling, R. Kramann and L. De Laporte
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https://doi.org/10.1002/adhm.202301030 | Advanced Healthcare Materials | 2023 | |
Transferrin Receptor-Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation
A. Dasgupta, T. Sun, E. Rama, A. Motta, Y. Zhang, C. Power, D. Moeckel, S.-M. Fletcher, M. Moosavifar, R. Barmin, C. Porte, E. M. Buhl, C. Bastard, R. M. Pallares, F. Kiessling, N. McDannold, S. Mitragotri and T. Lammers
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https://doi.org/10.1002/adma.202308150 | Advanced Materials | 2023 | |
On-Chip Fabrication of Colloidal Suprastructures by Assembly and Supramolecular Interlinking of Microgels
S.-H. Jung, F. Meyer, S. Hörnig, M. Bund, B. Häßel, L. P. B. Guerzoni, L. De Laporte, G. Ben Messaoud, S. P. Centeno and A. Pich
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https://doi.org/10.1002/smll.202303444 | Small | 2023 | |
Nonspherical Ultrasound Microbubbles
A. Dasgupta, T. Sun, R. Palomba, E. Rama, Y. Zhang, C. Power, D. Moeckel, M. Liu, A. Sarode, M. Weiler, A. Motta, C. Porte, Z. Magnuska, A. Said Elshafei, R. Barmin, A. Graham, A. McClelland, D. Rommel, E. Stickeler, F. Kiessling, R. M. Pallares, L. De Laporte, P. Decuzzi, N. McDannold, S. Mitragotri and T. Lammers
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https://doi.org/10.1073/pnas.2218847120 | Proceedings of the National Academy of Sciences | 2023 | |
Microgels as Platforms for Antibody-Mediated Cytokine Scavenging
S. Boesveld, Y. Kittel, Y. Luo, A. Jans, B. Oezcifci, M. Bartneck, C. Preisinger, D. Rommel, T. Haraszti, S. P. Centeno, A. J. Boersma, L. De Laporte, C. Trautwein, A. J. C. Kuehne and P. Strnad
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https://doi.org/10.1002/adhm.202300695 | Advanced Healthcare Materials | 2023 | |
Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology
A. Fernández-Colino, F. Kiessling, I. Slabu, L. De Laporte, P. Akhyari, S. K. Nagel, J. Stingl, S. Reese and S. Jockenhoevel
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https://doi.org/10.1002/adhm.202300991 | Advanced Healthcare Materials | 2023 | |
How Does Temporal and Sequential Delivery of Multiple Growth Factors Affect Vascularization inside 3d Hydrogels?
C. Bastard, D. Günther, J. Gerardo-Nava, M. Dewerchin, P. Sprycha, C. Licht, A. Lüken, M. Wessling and L. De Laporte
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https://doi.org/10.1002/adtp.202300091 | Advanced Therapeutics | 2023 | |
Cellular Architects at Work: Cells Building Their Own Microgel Houses
S. Bulut, D. Günther, M. Bund, C. Haats, T. Bissing, C. Bastard, M. Wessling, L. De Laporte and A. Pich
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https://doi.org/10.1002/adhm.202302957 | Advanced Healthcare Materials | 2023 | |
Cell Guiding Multicomponent Nanoyarn Tendon Scaffolds with Tunable Morphology and Flexibility
L. Schynkel, M. Meeremans, A. A. Meyer, E. Schoolaert, J. Geltmeyer, A. Omidinia-Anarkoli, S. Van Vlierberghe, L. Daelemans, L. De Laporte, C. De Schauwer, R. Hoogenboom and K. De Clerck
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https://doi.org/10.1021/acsami.3c08241 | ACS Applied Materials & Interfaces | 2023 |