The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Team
Projects
Publications
| Title/authors | Magazine | Year | |
|---|---|---|---|
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A thermostable flavin-based fluorescent protein from Chloroflexus aggregans: a framework for ultra-high resolution structural studies
V. V. Nazarenko, A. Remeeva, A. Yudenko, K. Kovalev, A. Dubenko, I. M. Goncharov, P. Kuzmichev, A. V. Rogachev, P. Buslaev, V. Borshchevskiy, A. Mishin, G. V. Dhoke, U. Schwaneberg, M. D. Davari, K. E. Jaeger, U. Krauss, V. Gordeliy and I. Gushchin
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Photochem Photobiol Sci | 2019 | To publication |
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Anchor Peptide-Mediated Surface Immobilization of a Grubbs-Hoveyda-Type Catalyst for Ring-Opening Metathesis Polymerization
A. R. S. Grimm, D. F.; Garakani, T. M.; Rubsam, K.; Polen, T.; Davari, M. D.; Jakob, F.; Schiffels, J.; Okuda, J.; Schwaneberg, U.
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Bioconjugate Chemistry | 2019 | To publication |
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Biadhesive Peptides for Assembling Stainless Steel and Compound Loaded Micro-Containers
L. Apitius, S. Buschmann, C. Bergs, D. Schonauer, F. Jakob, A. Pich and U. Schwaneberg
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Macromol Biosci | 2019 | To publication |
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Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein
D. F. Q. Sauer, Y.; Mertens, M. A. S.; Schiffels, J.; Polen, T.; Schwaneberg, U.; Okuda, J.
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Catalysis Science & Technology | 2019 | To publication |
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Chiral separation of D/L-arginine with whole cells through an engineered FhuA nanochannel
D. Anand, G. V. Dhoke, J. Gehrmann, T. M. Garakani, M. D. Davari, M. Bocola, L. L. Zhua and U. Schwaneberg
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Chemical Communications | 2019 | |
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Directed aryl sulfotransferase evolution toward improved sulfation stoichiometry on the example of catechols
Y. Ji, S. Islam, A. M. Mertens, D. F. Sauer, G. V. Dhoke, F. Jakob and U. Schwaneberg
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Applied Microbiology and Biotechnology | 2019 | |
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Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals
U. T. Bornscheuer, B. Hauer, K. E. Jaeger and U. Schwaneberg
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Angewandte Chemie-International Edition | 2019 | To publication |
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Directed Evolution of a Bacterial Laccase (CueO) for Enzymatic Biofuel Cells
L. L. C. Zhang, H. Y.; Zou, Z.; Garakani, T. M.; Novoa-Henriquez, C.; Jooyeh, B.; Schwaneberg, U.
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Angewandte Chemie-International Edition | 2019 | To publication |
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Directed Evolution of P450 BM3 towards Functionalization of Aromatic O-Heterocycles
G. A. Santos, G. V. Dhoke, M. D. Davari, A. J. Ruff and U. Schwaneberg
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Int J Mol Sci | 2019 | To publication |
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Disulfide Bond Engineering of an Endoglucanase from Penicillium verruculosum to Improve Its Thermostability
A. Bashirova, S. Pramanik, P. Volkov, A. Rozhkova, V. Nemashkalov, I. Zorov, A. Gusakov, A. Sinitsyn, U. Schwaneberg and M. D. Davari
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International Journal of Molecular Sciences | 2019 | |
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Engineered phytases for emerging biotechnological applications beyond animal feeding
K. R. Herrmann, A. J. Ruff, B. Infanzon and U. Schwaneberg
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Appl Microbiol Biotechnol | 2019 | To publication |
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High Throughput Screening Method for Engineering P450 Towards Terminal Hydroxylation of Fatty Acids
S. Q. Meng, J. Guo, K. L. Nie, U. Schwaneberg, T. W. Tan, H. J. Xu and L. Liu
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Journal of Biobased Materials and Bioenergy | 2019 |