The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Team
Projects
Publications
| Titel/Autoren | Magazine | Jahre | |
|---|---|---|---|
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A peptide-based coating toolbox to enable click chemistry on polymers, metals, and silicon through sortagging
M. Nöth, Z. Zou, I. El-Awaad, L. C. de Lencastre Novaes, G. Dilarri, M. D. Davari, H. Ferreira, F. Jakob and U. Schwaneberg
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Bioengineering | 2021 | Zur Publikation |
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An artificial ruthenium-containing β-barrel protein for alkene–alkyne coupling reaction
A. Thiel, D. F. Sauer, U. Markel, M. A. S. Mertens, T. Polen, U. Schwaneberg and J. Okuda
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Organic & Biomolecular Chemistry | 2021 | Zur Publikation |
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Chemogenetic engineering of nitrobindin toward an artificial epoxygenase
D. F. Sauer, M. Wittwer, U. Markel, A. Minges, M. Spiertz, J. Schiffels, M. D. Davari, G. Groth, J. Okuda and U. Schwaneberg
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Catalysis Science & Technology | 2021 | Zur Publikation |
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Chemogenetic Evolution of a Peroxidase-like Artificial Metalloenzyme
U. Markel, D. F. Sauer, M. Wittwer, J. Schiffels, H. Cui, M. D. Davari, K. W. Kröckert, S. Herres-Pawlis, J. Okuda and U. Schwaneberg
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ACS Catalysis | 2021 | Zur Publikation |
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CompassR-guided recombination unlocks design principles to stabilize lipases in ILs with minimal experimental efforts
H. Cui, S. Pramanik, K.-E. Jaeger, M. D. Davari and U. Schwaneberg
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Green Chemistry | 2021 | Zur Publikation |
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Fe(iii)-complex mediated bacterial cell surface immobilization of eGFP and enzymes
L. Feng, L. Gao, D. F. Sauer, Y. Ji, H. Cui and U. Schwaneberg
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Chemical Communications | 2021 | Zur Publikation |
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KnowVolution of prodigiosin ligase PigC towards condensation of short-chain prodiginines
S. Brands, H. U. C. Brass, A. S. Klein, J. G. Sikkens, M. D. Davari, J. Pietruszka, A. J. Ruff and U. Schwaneberg
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Catalysis Science & Technology | 2021 | Zur Publikation |
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Less Unfavorable Salt Bridges on the Enzyme Surface Result in More Organic Cosolvent Resistance
H. Cui, L. Eltoukhy, L. Zhang, U. Markel, K.-E. Jaeger, M. D. Davari and U. Schwaneberg
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Angewandte Chemie International Edition | 2021 | Zur Publikation |
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Rapid and Oriented Immobilization of Laccases on Electrodes via a Methionine-Rich Peptide
H. Cui, L. Zhang, D. Söder, X. Tang, M. D. Davari and U. Schwaneberg
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ACS Catalysis | 2021 | Zur Publikation |
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Tunnel engineering for modulating the substrate preference in cytochrome P450BsβHI
S. Meng, R. An, Z. Li, U. Schwaneberg, Y. Ji, M. D. Davari, F. Wang, M. Wang, M. Qin, K. Nie and L. Liu
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Bioresources and Bioprocessing | 2021 | Zur Publikation |
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Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
S. Brands, J. G. Sikkens, M. D. Davari, H. U. C. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff and U. Schwaneberg
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Chemical Communications | 2021 | Zur Publikation |
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Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
S. Brands, J. G. Sikkens, M. D. Davari, H. U. C. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff and U. Schwaneberg
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Chemical Communications | 2021 | Zur Publikation |