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Research Group Schwaneberg

Molecular Biotechnology & Protein Engineering
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Expertise

The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.

Member of the Scientific Board

Prof. Dr. Ulrich Schwaneberg

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  • PhD student

    Ahmed Hegazy, M.Sc.

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    B -1.51
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    Hegazy
  • Science Support Team

    Christian Simons, M.Sc.

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    B -1.51
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    Simons
  • Postdoc

    Deniz Thiel

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    B0.57 / B-1.51
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  • Postdoc

    Dr. Alexander Boes

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    A1.14
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    Boes
  • Postdoc

    Dr. Amanda Staudt

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  • Postdoc

    Dr. Florian Bourdeaux

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  • Dr. Nikola Mijailovic

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  • Project Leader

    Dr. Patrick J. Bakkes

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  • Postdoc

    Jan Gebauer

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    B0.57
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  • Science Support Team

    Jens Gruber

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    B-1.51
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  • PhD student

    Julian Karl

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    B-1.51
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    Julian Karl
  • Science Support Team

    Michael Eßer

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    Eßer
  • Project

    EcoGuard

    Rainproof delivery systems to protect vine against vine peronospora and cherry vinegar fly (2818OE039)
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  • Project

    PEBIOTE

    PEPBIOTE Anchor Peptide as a green and versatile stategies for applicateion of BIObased additives in coating of Textiles
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  • Project

    ProSeed

    Mikroplastik freie Saatgutbehandlung
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  • Project

    BioCoat

    BioTexFuture - Bio-based coatings for bio-based fibres in high-performance textiles
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  • Project

    Ankerpeptide

    Eine grüne und vielseitige Strategie für die Applikation von BIObasierten Additiven in Textil- und Kunststoffbeschichtungen
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  • Project

    Anchor peptides that bind to hair

    Identification of anchor peptides that can specifically bind to the surface of hair without simultaneously binding to skin cells
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  • Project

    In FuProts

    Rainfasten Insecticidal Fusion Proteins for Plant Protection
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  • Project

    Bio4MatPro

    Competence Center for the Biological Transformation of Materials Science and Production Engineering
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  • Project

    PleuraPlug

    Surface functionalized bio-based and injectable patches for tissue regeneration for traumatic pleural injuries
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  • Project

    GreenProtect

    A Sustainable Release System to Produce More Healthy Food with Less Pesticide
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  • Project

    KlarTEXt

    Cooperation platform to dynamise a sustainable and transformative textile economy
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  • Project

    Heart2.0

    Development of an active interface system for the interior of artificial hearts and heart support systems
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  • Publication

    Grafting PNIPAAm from beta-barrel shaped transmembrane nanopores

    H. Charan, J. Kinzel, U. Glebe, D. Anand, T. M. Garakani, L. L. Zhu, M. Bocola, U. Schwaneberg and A. Boker
    Biomaterials Vol. 107 115-123 (2016)
    https://www.doi.org/10.1016/j.biomaterials.2016.08.033
  • Publication

    Photophysics of the LOV-Based Fluorescent Protein Variant iLOV-Q489K Determined by Simulation and Experiment

    M. D. Davari, B. Kopka, M. Wingen, M. Bocola, T. Drepper, K. E. Jaeger, U. Schwaneberg and U. Krauss
    Journal of Physical Chemistry B Vol. 120 (13) 3344-3352 (2016)
    https://www.doi.org/10.1021/acs.jpcb.6b01512
  • Publication

    What's My Substrate? Computational Function Assignment of Candida parapsilosis ADH5 by Genome Database Search, Virtual Screening, and QM/MM Calculations

    G. V. Dhoke, Y. Ensari, M. D. Davari, A. J. Ruff, U. Schwaneberg and M. Bocola
    Journal of Chemical Information and Modeling Vol. 56 (7) 1313-1323 (2016)
    https://www.doi.org/10.1021/acs.jcim.6b00076
  • Publication

    CaLB Catalyzed Conversion of epsilon-Caprolactone in Aqueous Medium. Part 1: Immobilization of CaLB to Microgels

    S. Engel, H. Hock, M. Bocola, H. Keul, U. Schwaneberg and M. Moller
    Polymers Vol. 8 (10) (2016)
    https://www.doi.org/10.3390/polym8100372
  • Publication

    A whole cell biocatalyst for double oxidation of cyclooctane

    C. A. Muller, A. M. Weingartner, A. Dennig, A. J. Ruff, H. Groger and U. Schwaneberg
    Journal of Industrial Microbiology & Biotechnology Vol. 43 (12) 1641-1646 (2016)
    https://www.doi.org/10.1007/s10295-016-1844-5
  • Publication

    Reactive Copolymers Based on N-Vinyl Lactams with Pyridyl Disulfide Side Groups via RAFT Polymerization and Postmodification via Thiol-Disulfide Exchange Reaction

    H. Peng, K. Rubsam, X. B. Huang, F. Jakob, M. Karperien, U. Schwaneberg and A. Pich
    Macromolecules Vol. 49 (19) 7141-7154 (2016)
    https://www.doi.org/10.1021/acs.macromol.6b01210
  • Publication

    Reversible Deactivation of Enzymes by Redox-Responsive Nanogel Carriers

    H. Peng, K. Rubsam, F. Jakob, P. Pazdzior, U. Schwaneberg and A. Pich
    Macromolecular Rapid Communications Vol. 37 (21) 1765-1771 (2016)
    https://www.doi.org/10.1002/marc.201600476
  • Publication

    Tunable Enzymatic Activity and Enhanced Stability of Cellulase Immobilized in Biohybrid Nanogels

    H. Peng, K. Rubsam, F. Jakob, U. Schwaneberg and A. Pich
    Biomacromolecules Vol. 17 (11) 3619-3631 (2016)
    https://www.doi.org/10.1021/acs.biomac.6b01119
  • Publication

    Screening through the PLICable promoter toolbox enhances protein production in Escherichia coli

    J. H. Yang, A. J. Ruff, S. N. Hamer, F. Cheng and U. Schwaneberg
    Biotechnology Journal Vol. 11 (12) 1639-1647 (2016)
    https://www.doi.org/10.1002/biot.201600270
  • Publication

    Directed evolution of P450cin for mediated electron transfer

    K. D. Belsare, T. Horn, A. J. Ruff, R. Martinez, A. Magnusson, D. Holtmann, J. Schrader and U. Schwaneberg
    Protein Engineering Design & Selection Vol. 30 (2) 119-127 (2017)
    https://www.doi.org/10.1093/protein/gzw072
  • Publication

    Sugar-Improved Enzymatic Synthesis of Biodiesel with Yarrowia lipolytica Lipase 2

    H. Cao, M. Wang, L. Deng, L. Liu, U. Schwaneberg, T. W. Tan, F. Wang and K. L. Nie
    Energy & Fuels Vol. 31 (6) 6248-6256 (2017)
    https://www.doi.org/10.1021/acs.energyfuels.7b01091
  • Publication

    Nano-thin walled micro-compartments from transmembrane protein-polymer conjugates

    H. Charan, U. Glebe, D. Anand, J. Kinzel, L. L. Zhu, M. Bocola, T. M. Garakani, U. Schwaneberg and A. Boker
    Soft Matter Vol. 13 (15) 2866-2875 (2017)
    https://www.doi.org/10.1039/c6sm02520j
  • Publication

    An Enzymatic Route to alpha-Tocopherol Synthons: Aromatic Hydroxylation of Pseudocumene and Mesitylene with P450 BM3

    A. Dennig, A. M. Weingartner, T. Kardashliev, C. A. Muller, E. Tassano, M. Schurmann, A. J. Ruff and U. Schwaneberg
    Chemistry-a European Journal Vol. 23 (71) 17981-17991 (2017)
    https://www.doi.org/10.1002/chem.201703647
  • Publication

    Inversion of cpADH5 Enantiopreference and Altered Chain Length Specificity for Methyl 3-Hydroxyalkanoates

    Y. Ensari, G. V. Dhoke, M. D. Davari, M. Bocola, A. J. Ruff and U. Schwaneberg
    Chemistry-a European Journal Vol. 23 (51) 12636-12645 (2017)
    https://www.doi.org/10.1002/chem.201702581
  • Publication

    Sortase-Mediated Surface Functionalization of Stimuli-Responsive Microgels

    E. Gau, D. M. Mate, Z. Zou, A. Oppermann, A. Topel, F. Jakob, D. Woll, U. Schwaneberg and A. Pich
    Biomacromolecules Vol. 18 (9) 2789-2798 (2017)
    https://www.doi.org/10.1021/acs.biomac.7b00720
  • Publication

    2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of beta-barrel hybrid catalyst for phenylacetylene polymerization

    J. Kinzel, D. F. Sauer, M. Bocola, M. Arlt, T. M. Garakani, A. Thiel, K. Beckerle, T. Polen, J. Okuda and U. Schwaneberg
    Beilstein Journal of Organic Chemistry Vol. 13 1498-1506 (2017)
    https://www.doi.org/10.3762/bjoc.13.148
  • Publication

    Electron transfer pathways in a light, oxygen, voltage (LOV) protein devoid of the photoactive cysteine

    B. Kopka, K. Magerl, A. Savitsky, M. D. Davari, K. Rollen, M. Bocola, B. Dick, U. Schwaneberg, K. E. Jaeger and U. Krauss
    Scientific Reports Vol. 7 (2017)
    https://www.doi.org/10.1038/s41598-017-13420-1
  • Publication

    Engineering Enhanced Pore Sizes Using FhuA Delta 1-160 from E. coli Outer Membrane as Template

    Z. Z. Liu, I. Ghai, M. Winterhalter and U. Schwaneberg
    Acs Sensors Vol. 2 (11) 1619-1626 (2017)
    https://www.doi.org/10.1021/acssensors.7b00481
  • Publication

    Are Directed Evolution Approaches Efficient in Exploring Nature's Potential to Stabilize a Lipase in Organic Cosolvents?

    U. Markel, L. L. Zhu, V. J. Frauenkron-Machedjou, J. Zhao, M. Bocola, M. D. Davari, K. E. Jaeger and U. Schwaneberg
    Catalysts Vol. 7 (5) (2017)
    https://www.doi.org/10.3390/catal7050142
  • Publication

    Biofunctional Microgel-Based Fertilizers for Controlled Foliar Delivery of Nutrients to Plants

    R. A. Meurer, S. Kemper, S. Knopp, T. Eichert, F. Jakob, H. E. Goldbach, U. Schwaneberg and A. Pich
    Angewandte Chemie-International Edition Vol. 56 (26) 7380-7386 (2017)
    https://www.doi.org/10.1002/anie.201701620
  • Publication

    Anchor peptides: A green and versatile method for polypropylene functionalization

    K. Rubsam, B. Stomps, A. Boker, F. Jakob and U. Schwaneberg
    Polymer Vol. 116 124-132 (2017)
    https://www.doi.org/10.1016/j.polymer.2017.03.070
  • Publication

    Casting epPCR (cepPCR): A Simple Random Mutagenesis Method to Generate High Quality Mutant Libraries

    J. H. Yang, A. J. Ruff, M. Arlt and U. Schwaneberg
    Biotechnology and Bioengineering Vol. 114 (9) 1921-1927 (2017)
    https://www.doi.org/10.1002/bit.26327
  • Publication

    Sortase-Mediated Ligation of Purely Artificial Building Blocks

    X. L. Dai, D. M. Mate, U. Glebe, T. M. Garakani, A. Korner, U. Schwaneberg and A. Boker
    Polymers Vol. 10 (2) (2018)
    https://www.doi.org/10.3390/polym10020151
  • Publication

    A Comparative Reengineering Study of cpADH5 through Iterative and Simultaneous Multisite Saturation Mutagenesis

    Y. Ensari, G. V. Dhoke, M. D. Davari, A. J. Ruff and U. Schwaneberg
    Chembiochem Vol. 19 (14) 1563-1569 (2018)
    https://www.doi.org/10.1002/cbic.201800159
  • Publication

    Theoretical Model of the Protochlorophyllide Oxidoreductase from a Hierarchy of Protocols

    S. Gholami, A. Nenov, I. Rivalta, M. Bocola, A. K. Bordbar, U. Schwaneberg, M. D. Davari and M. Garavelli
    Journal of Physical Chemistry B Vol. 122 (31) 7668-7681 (2018)
    https://www.doi.org/10.1021/acs.jpcb.8b04231
  • Publication

    Cavity Size Engineering of a β-Barrel Protein Generates Efficient Biohybrid Catalysts for Olefin Metathesis

    A. R. Grimm, D. F. Sauer, M. D. Davari, L. L. Zhu, M. Bocola, S. Kato, A. Onoda, T. Hayashi, J. Okuda and U. Schwaneberg
    Acs Catalysis Vol. 8 (4) 3358-3364 (2018)
    https://www.doi.org/10.1021/acscatal.7b03652
  • Publication

    A Whole Cell E. coli Display Platform for Artificial Metalloenzymes: Poly(phenylacetylene) Production with a Rhodium-Nitrobindin Metalloprotein

    A. R. Grimm, D. F. Sauer, T. Polen, L. L. Zhu, T. Hayashi, J. Okuda and U. Schwaneberg
    Acs Catalysis Vol. 8 (3) 2611-2614 (2018)
    https://www.doi.org/10.1021/acscatal.7b04369
  • Publication

    Comparison of Candida antarctica Lipase B Variants for Conversion of epsilon-Caprolactone in Aqueous MediumPart 2

    H. Hock, S. Engel, S. Weingarten, H. Keul, U. Schwaneberg, M. Moller and M. Bocola
    Polymers Vol. 10 (5) (2018)
    https://www.doi.org/10.3390/polym10050524
  • Publication

    KnowVolution Campaign of an Aryl Sulfotransferase Increases Activity toward Cellobiose

    S. Islam, D. Laaf, B. Infanzon, H. Pelantova, M. D. Davari, F. Jakob, V. Kren, L. Elling and U. Schwaneberg
    Chemistry-a European Journal Vol. 24 (64) 17117-17124 (2018)
    https://www.doi.org/10.1002/chem.201803729
  • Publication

    A robust protocol for directed aryl sulfotransferase evolution toward the carbohydrate building block GlcNAc

    S. Islam, D. M. Mate, R. Martinez, F. Jakob and U. Schwaneberg
    Biotechnology and Bioengineering Vol. 115 (5) 1106-1115 (2018)
    https://www.doi.org/10.1002/bit.26535
  • Publication

    Directed OmniChange Evolution Converts P450 BM3 into an Alkyltrimethylammonium Hydroxylase

    Y. Ji, A. M. Mertens, C. Gertler, S. Fekiri, M. Keser, D. F. Sauer, K. E. C. Smith and U. Schwaneberg
    Chemistry-a European Journal Vol. 24 (63) 16865-16872 (2018)
    https://www.doi.org/10.1002/chem.201803806
  • Publication

    Directed evolution of an acid Yersinia mollaretii phytase for broadened activity at neutral pH

    G. Korfer, C. Novoa, J. Kern, E. Balla, C. Grutering, M. D. Davari, R. Martinez, L. Vojcic and U. Schwaneberg
    Applied Microbiology and Biotechnology Vol. 102 (22) 9607-9620 (2018)
    https://www.doi.org/10.1007/s00253-018-9308-7
  • Publication

    Directed Evolution of Hyaluronic Acid Synthase from Pasteurella multocida towards High-Molecular-Weight Hyaluronic Acid

    J. Mandawe, B. Infanzon, A. Eisele, H. Zaun, J. Kuballa, M. D. Davari, F. Jakob, L. Elling and U. Schwaneberg
    Chembiochem Vol. 19 (13) 1414-1423 (2018)
    https://www.doi.org/10.1002/cbic.201800093
  • Publication

    Crystallographic insights into a cobalt (III) sepulchrate based alternative cofactor system of P450 BM3 monooxygenase

    S. Panneerselvam, A. Shehzad, J. Mueller-Dieckmann, M. Wilmanns, M. Bocola, M. D. Davari and U. Schwaneberg
    Biochimica Et Biophysica Acta-Proteins and Proteomics Vol. 1866 (1) 134-140 (2018)
    https://www.doi.org/10.1016/j.bbapap.2017.07.010
  • Publication

    KnowVolution of the Polymer-Binding Peptide LCI for Improved Polypropylene Binding

    K. Rubsam, M. D. Davari, F. Jakob and U. Schwaneberg
    Polymers Vol. 10 (4) (2018)
    https://www.doi.org/10.3390/polym10040423
  • Publication

    Directed evolution of polypropylene and polystyrene binding peptides

    K. Rubsam, L. Weber, F. Jakob and U. Schwaneberg
    Biotechnology and Bioengineering Vol. 115 (2) 321-330 (2018)
    https://www.doi.org/10.1002/bit.26481
  • Publication

    Enzyme-Polyelectrolyte Complexes Boost the Catalytic Performance of Enzymes

    M. J. Thiele, M. D. Davari, M. Konig, I. Hofmann, N. O. Junker, T. M. Garakani, L. Vojcic, J. Fitter and U. Schwaneberg
    Acs Catalysis Vol. 8 (11) 10876-10887 (2018)
    https://www.doi.org/10.1021/acscatal.8b02935
  • Publication

    A loop engineering strategy improves laccase lcc2 activity in ionic liquid and aqueous solution

    A. M. Wallraf, H. F. Liu, L. L. Zhu, G. Khalfallah, C. Simons, H. Alibiglou, M. D. Davari and U. Schwaneberg
    Green Chemistry Vol. 20 (12) 2801-2812 (2018)
    https://www.doi.org/10.1039/c7gc03776g
  • Publication

    A hydroquinone-specific screening system for directed P450 evolution

    A. M. Weingartner, D. F. Sauer, G. V. Dhoke, M. D. Davari, A. J. Ruff and U. Schwaneberg
    Applied Microbiology and Biotechnology Vol. 102 (22) 9657-9667 (2018)
    https://www.doi.org/10.1007/s00253-018-9328-3
  • Publication

    Unraveling the effects of amino acid substitutions enhancing lipase resistance to an ionic liquid: a molecular dynamics study

    J. Zhao, V. J. Frauenkron-Machedjou, A. Fulton, L. L. Zhu, M. D. Davari, K. E. Jaeger, U. Schwaneberg and M. Bocola
    Physical Chemistry Chemical Physics Vol. 20 (14) 9600-9609 (2018)
    https://www.doi.org/10.1039/c7cp08470f
  • Publication

    Directed sortase A evolution for efficient site-specific bioconjugations in organic co-solvents

    Z. Zou, H. Alibiglou, D. M. Mate, M. D. Davari, F. Jakob and U. Schwaneberg
    Chemical Communications Vol. 54 (81) 11467-11470 (2018)
    https://www.doi.org/10.1039/c8cc06017g
  • Publication

    Sortase-Mediated High-Throughput Screening Platform for Directed Enzyme Evolution

    Z. Zou, D. M. Mate, K. Rubsam, F. Jakob and U. Schwaneberg
    Acs Combinatorial Science Vol. 20 (4) 203-211 (2018)
    https://www.doi.org/10.1021/acscombsci.7b00153
  • Publication

    Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals

    U. T. Bornscheuer, B. Hauer, K. E. Jaeger and U. Schwaneberg
    Angewandte Chemie-International Edition Vol. 58 (1) 36-40 (2019)
    https://www.doi.org/10.1002/anie.201812717
  • Publication

    Anchor Peptide-Mediated Surface Immobilization of a Grubbs-Hoveyda-Type Catalyst for Ring-Opening Metathesis Polymerization

    A. R. S. Grimm, D. F.; Garakani, T. M.; Rubsam, K.; Polen, T.; Davari, M. D.; Jakob, F.; Schiffels, J.; Okuda, J.; Schwaneberg, U.
    Bioconjugate Chemistry Vol. 30 (3) 714-720 (2019)
    https://www.doi.org/10.1021/acs.bioconjchem.8b00874
  • Publication

    Targeting microplastic particles in the void of diluted suspensions

    Islam, S., Apitius, L., Jakob, F., Schwaneberg, U.
    Environment International Vol. 123 428-435 (2019)
    https://www.doi.org/10.1016/j.envint.2018.12.029
  • Publication

    Towards the Evolution of Artificial Metalloenzymes-A Protein Engineer's Perspective

    U. S. Markel, D. F.; Schiffels, J.; Okuda, J.; Schwaneberg, U.
    Angewandte Chemie-International Edition Vol. 58 (14) 4454-4464 (2019)
    https://www.doi.org/10.1002/anie.201811042
  • Publication

    Stimuli-Responsive Poly(N-Vinyllactams) with Glycidyl Side Groups: Synthesis, Characterization, and Conjugation with Enzymes

    H. Peng, K. Rubsam, C. Hu, F. Jakob, U. Schwaneberg and A. Pich
    Biomacromolecules Vol. 20 (2) 992-1006 (2019)
    https://www.doi.org/10.1021/acs.biomac.8b01608
  • Publication

    Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

    D. F. Q. Sauer, Y.; Mertens, M. A. S.; Schiffels, J.; Polen, T.; Schwaneberg, U.; Okuda, J.
    Catalysis Science & Technology Vol. 9 (4) 942-946 (2019)
    https://www.doi.org/10.1039/c8cy02236d
  • Publication

    Directed Evolution of a Bacterial Laccase (CueO) for Enzymatic Biofuel Cells

    L. L. C. Zhang, H. Y.; Zou, Z.; Garakani, T. M.; Novoa-Henriquez, C.; Jooyeh, B.; Schwaneberg, U.
    Angewandte Chemie-International Edition Vol. 58 (14) 4562-4565 (2019)
    https://www.doi.org/10.1002/anie.201814069
  • Publication

    Enzyme‐Compatible Dynamic Nanoreactors from Electrostatically Bridged Like‐Charged Surfactants and Polyelectrolytes

    M. J. Thiele, M. D. Davari, I. Hofmann, M. König, C. G. Lopez, L. Vojcic, W. Richtering, U. Schwaneberg and L. A. Tsarkova
    Angewandte Chemie-International Edition Vol. 57 (30) 9402-9407 (2018)
    https://doi.org/10.1002/anie.201805021
  • Publication

    In vitro flow cytometry-based screening platform for cellulase engineering

    G. Korfer, C. Pitzler, L. Vojcic, R. Martinez and U. Schwaneberg
    Sci Rep Vol. 6 26128 (2016)
    https://www.doi.org/10.1038/srep26128
  • Publication

    Chiral separation of D/L-arginine with whole cells through an engineered FhuA nanochannel

    D. Anand, G. V. Dhoke, J. Gehrmann, T. M. Garakani, M. D. Davari, M. Bocola, L. L. Zhua and U. Schwaneberg
    Chemical Communications Vol. 55 (38) 5431-5434 (2019)
    https://doi.org/10.1039/c9cc00154a
  • Publication

    Disulfide Bond Engineering of an Endoglucanase from Penicillium verruculosum to Improve Its Thermostability

    A. Bashirova, S. Pramanik, P. Volkov, A. Rozhkova, V. Nemashkalov, I. Zorov, A. Gusakov, A. Sinitsyn, U. Schwaneberg and M. D. Davari
    International Journal of Molecular Sciences Vol. 20 (7) (2019)
    https://doi.org/10.3390/ijms20071602
  • Publication

    Directed aryl sulfotransferase evolution toward improved sulfation stoichiometry on the example of catechols

    Y. Ji, S. Islam, A. M. Mertens, D. F. Sauer, G. V. Dhoke, F. Jakob and U. Schwaneberg
    Applied Microbiology and Biotechnology Vol. 103 (9) 3761-3771 (2019)
    http://doi.org/10.1007/s00253-019-09688-0
  • Publication

    High Throughput Screening Method for Engineering P450 Towards Terminal Hydroxylation of Fatty Acids

    S. Q. Meng, J. Guo, K. L. Nie, U. Schwaneberg, T. W. Tan, H. J. Xu and L. Liu
    Journal of Biobased Materials and Bioenergy Vol. 13 (1) 79-85 (2019)
    https://doi.org/10.1166/jbmb.2019.1816
  • Publication

    Ternary Complex Formation and Photoactivation of a Photoenzyme Results in Altered Protein Dynamics

    A. M. Stadler, J. Schneidewind, M. Zamponi, E. Knieps-Grunhagen, S. Gholami, U. Schwaneberg, I. Rivalta, M. Garavelli, M. D. Davari, K. E. Jaeger and U. Krauss
    J Phys Chem B (2019)
    https://www.doi.org/10.1021/acs.jpcb.9b06608
  • Publication

    Directed Evolution of P450 BM3 towards Functionalization of Aromatic O-Heterocycles

    G. A. Santos, G. V. Dhoke, M. D. Davari, A. J. Ruff and U. Schwaneberg
    Int J Mol Sci Vol. 20 (13) (2019)
    https://www.doi.org/10.3390/ijms20133353
  • Publication

    KnowVolution of a Fungal Laccase toward Alkaline pH

    C. Novoa, G. V. Dhoke, D. M. Mate, R. Martinez, T. Haarmann, M. Schreiter, J. Eidner, R. Schwerdtfeger, P. Lorenz, M. D. Davari, F. Jakob and U. Schwaneberg
    Chembiochem Vol. 20 (11) 1458-1466 (2019)
    https://www.doi.org/10.1002/cbic.201800807
  • Publication

    A thermostable flavin-based fluorescent protein from Chloroflexus aggregans: a framework for ultra-high resolution structural studies

    V. V. Nazarenko, A. Remeeva, A. Yudenko, K. Kovalev, A. Dubenko, I. M. Goncharov, P. Kuzmichev, A. V. Rogachev, P. Buslaev, V. Borshchevskiy, A. Mishin, G. V. Dhoke, U. Schwaneberg, M. D. Davari, K. E. Jaeger, U. Krauss, V. Gordeliy and I. Gushchin
    Photochem Photobiol Sci Vol. 18 (7) 1793-1805 (2019)
    https://www.doi.org/10.1039/c9pp00067d
  • Publication

    In Situ Monitoring of Membrane Protein Insertion into Block Copolymer Vesicle Membranes and Their Spreading via Potential-Assisted Approach

    T. Mirzaei Garakani, Z. Liu, U. Glebe, J. Gehrmann, J. Lazar, M. A. S. Mertens, M. Moller, N. Hamzelui, L. Zhu, U. Schnakenberg, A. Boker and U. Schwaneberg
    ACS Appl Mater Interfaces Vol. 11 (32) 29276-29289 (2019)
    https://www.doi.org/10.1021/acsami.9b09302
  • Publication

    Membrane-Mimetic Dendrimersomes Engulf Living Bacteria via Endocytosis

    N. Y. Kostina, K. Rahimi, Q. Xiao, T. Haraszti, S. Dedisch, J. P. Spatz, U. Schwaneberg, M. L. Klein, V. Percec, M. Moller and C. Rodriguez-Emmenegger
    Nano Lett Vol. 19 (8) 5732-5738 (2019)
    https://www.doi.org/10.1021/acs.nanolett.9b02349
  • Publication

    Engineered phytases for emerging biotechnological applications beyond animal feeding

    K. R. Herrmann, A. J. Ruff, B. Infanzon and U. Schwaneberg
    Appl Microbiol Biotechnol Vol. 103 (16) 6435-6448 (2019)
    https://www.doi.org/10.1007/s00253-019-09962-1
  • Publication

    Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency

    F. Cheng, J. Yang, U. Schwaneberg and L. Zhu
    Biotechnol Bioeng Vol. 116 (9) 2156-2166 (2019)
    https://www.doi.org/10.1002/bit.27011
  • Publication

    Ultrahigh-throughput screening system for directed polymer binding peptide evolution

    L. Apitius, K. Rubsam, C. Jakesch, F. Jakob and U. Schwaneberg
    Biotechnol Bioeng Vol. 116 (8) 1856-1867 (2019)
    https://www.doi.org/10.1002/bit.26990
  • Publication

    Biadhesive Peptides for Assembling Stainless Steel and Compound Loaded Micro-Containers

    L. Apitius, S. Buschmann, C. Bergs, D. Schonauer, F. Jakob, A. Pich and U. Schwaneberg
    Macromol Biosci e1900125 (2019)
    https://www.doi.org/10.1002/mabi.201900125
  • Publication

    Consensus model of a cyanobacterial light-dependent protochlorophyllide oxidoreductase in its pigment-free apo-form and photoactive ternary complex

    J. Schneidewind, F. Krause, M. Bocola, A. M. Stadler, M. D. Davari, U. Schwaneberg, K.-E. Jaeger and U. Krauss
    Communications Biology Vol. 2 (1) 351 (2019)
    https://www.doi.org/10.1038/s42003-019-0590-4
  • Publication

    Computer-assisted Recombination (CompassR) teaches us how to recombine beneficial substitutions from directed evolution campaigns

    H. Cui, H. Cao, H. Cai, J. Karl-Erich, M. D. Davari and U. Schwaneberg
    Chemistry – A European Journal Vol. 0 (0) (2019)
    https://www.doi.org/10.1002/chem.201903994
  • Publication

    Matter-tag: A universal immobilization platform for enzymes on polymers, metals, and silicon-based materials

    S. Dedisch, A. Wiens, M. D. Davari, D. Söder, C. Rodriguez-Emmenegger, F. Jakob and U. Schwaneberg
    Biotechnology and Bioengineering Vol. 117 (1) (2019)
    https://www.doi.org/10.1002/bit.27181
  • Publication

    Selective Functionalization of Microgels with Enzymes by Sortagging

    Z. Zou, E. Gau, I. El-Awaad, F. Jakob, A. Pich and U. Schwaneberg
    Bioconjugate Chemistry Vol. 30 (11) 2859-2869 (2019)
    https://www.doi.org/10.1021/acs.bioconjchem.9b00568
  • Publication

    Critical effect of proline on thermostability of endoglucanase II from Penicillium verruculosum

    A. S. Dotsenko, S. Pramanik, A. V. Gusakov, A. M. Rozhkova, I. N. Zorov, A. P. Sinitsyn, M. D. Davari and U. Schwaneberg
    Biochemical Engineering Journal Vol. 152 107395 (2019)
    https://doi.org/10.1016/j.bej.2019.107395
  • Publication

    Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

    M. A. S. Mertens, D. F. Sauer, U. Markel, J. Schiffels, J. Okuda and U. Schwaneberg
    Catalysis Science & Technology Vol. 9 (20) 5572-5576 (2019)
    https://www.doi.org/10.1039/C9CY01412H
  • Publication

    One-Pot Two-Step Chemoenzymatic Cascade for the Synthesis of a Bis-benzofuran Derivative

    M. A. S. Mertens, F. Thomas, M. Nöth, J. Moegling, I. El-Awaad, D. F. Sauer, G. V. Dhoke, W. Xu, A. Pich, S. Herres-Pawlis and U. Schwaneberg
    European Journal of Organic Chemistry Vol. 2019 (37) 6341-6346 (2019)
    https://www.doi.org/10.1002/ejoc.201900904
  • Publication

    Rapid and Robust Coating Method to Render Polydimethylsiloxane Surfaces Cell-Adhesive

    D. B. Gehlen, L. C. De Lencastre Novaes, W. Long, A. J. Ruff, F. Jakob, T. Haraszti, Y. Chandorkar, L. Yang, P. van Rijn, U. Schwaneberg and L. De Laporte
    ACS Appl Mater Interfaces (2019)