The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Team
Projects
Publications
| Titel/Autoren | Magazine | Jahre | |
|---|---|---|---|
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A Plea for the Integration of Green Toxicology in Sustainable Bioeconomy Strategies – Biosurfactants and Microgel-Based Pesticide Release Systems as Examples
S. Johann, F. G. Weichert, L. Schröer, L. Stratemann, C. Kämpfer, T.-B. Seiler, S. Heger, A. Töpel, T. Sassmann, A. Pich, F. Jakob, U. Schwaneberg, P. Stoffels, M. Philipp, M. Terfrüchte, A. Loeschcke, K. Schipper, M. Feldbrügge, N. Ihling, J. Büchs, I. Bator, T. Tiso, L. M. Blank, M. Roß-Nickoll and H. Hollert
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Journal of Hazardous Materials | 2022 | |
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Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to in Vitro Blood Flow
P. Winnersbach, A. Hosseinnejad, T. Breuer, T. Fechter, F. Jakob, U. Schwaneberg, R. Rossaint, C. Bleilevens and S. Singh
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Membranes (Basel) | 2022 | |
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In Silico and Experimental Adam17 Kinetic Modeling as Basis for Future Screening System for Modulators
M. Bienstein, D. Minond, U. Schwaneberg, M. D. Davari and D. Yildiz
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International Journal of Molecular Sciences | 2022 | |
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Optimized Hemolysin Type 1 Secretion System in Escherichia Coli by Directed Evolution of the Hly Enhancer Fragment and Including a Terminator Region
Z. Pourhassan N., H. Cui, S. Khosa, M. D. Davari, K.-E. Jaeger, S. H. J. Smits, U. Schwaneberg and L. Schmitt
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ChemBioChem | 2022 | |
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Polar Substitutions on the Surface of a Lipase Substantially Improve Tolerance in Organic Solvents
H. Cui, M. Vedder, L. Zhang, K.-E. Jaeger, U. Schwaneberg and M. D. Davari
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ChemSusChem | 2022 | |
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Preparative Production of Functionalized (N- and O-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3a4 in a Bioreactor
M. Srdič, N. D. Fessner, D. Yildiz, A. Glieder, M. Spiertz and U. Schwaneberg
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Biomolecules | 2022 | |
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Structure and Cooperativity in Substrate–Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design
E. Rajakumara, S. Abhishek, K. Nitin, D. Saniya, P. Bajaj, U. Schwaneberg and M. D. Davari
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ACS Chemical Biology | 2022 | |
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A peptide-based coating toolbox to enable click chemistry on polymers, metals, and silicon through sortagging
M. Nöth, Z. Zou, I. El-Awaad, L. C. de Lencastre Novaes, G. Dilarri, M. D. Davari, H. Ferreira, F. Jakob and U. Schwaneberg
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Bioengineering | 2021 | |
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An artificial ruthenium-containing β-barrel protein for alkene–alkyne coupling reaction
A. Thiel, D. F. Sauer, U. Markel, M. A. S. Mertens, T. Polen, U. Schwaneberg and J. Okuda
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Organic & Biomolecular Chemistry | 2021 | |
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Aqueous Ionic Liquids Redistribute Local Enzyme Stability Via Long-Range Perturbation Pathways
T. El Harrar, B. Frieg, M. D. Davari, K.-E. Jaeger, U. Schwaneberg and H. Gohlke
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Computational and Structural Biotechnology Journal | 2021 | |
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Chapter Thirteen - Anchor Peptides Promote Degradation of Mixed Plastics for Recycling
Y. Ji, Y. Lu, H. Puetz and U. Schwaneberg
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Methods in Enzymology | 2021 | |
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Chemogenetic engineering of nitrobindin toward an artificial epoxygenase
D. F. Sauer, M. Wittwer, U. Markel, A. Minges, M. Spiertz, J. Schiffels, M. D. Davari, G. Groth, J. Okuda and U. Schwaneberg
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Catalysis Science & Technology | 2021 |