The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Team
Projects
Publications
| Title/authors | Magazine | Year | |
|---|---|---|---|
|
Advances in ultrahigh-throughput screening for directed enzyme evolution
U. Markel, K. D. Essani, V. Besirlioglu, J. Schiffels, W. R. Streit and U. Schwaneberg
|
Chemical Society Reviews | 2020 | To publication |
|
A 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3
A. Gartner, A. J. Ruff and U. Schwaneberg
|
Scientific Reports | 2019 | To publication |
|
A bifunctional dermaseptin–thanatin dipeptide functionalizes the crop surface for sustainable pest management
P. Schwinges, S. Pariyar, F. Jakob, M. Rahimi, L. Apitius, M. Hunsche, L. Schmitt, G. Noga, C. Langenbach, U. Schwaneberg and U. Conrath
|
Green Chemistry | 2019 | To publication |
|
A thermostable flavin-based fluorescent protein from Chloroflexus aggregans: a framework for ultra-high resolution structural studies
V. V. Nazarenko, A. Remeeva, A. Yudenko, K. Kovalev, A. Dubenko, I. M. Goncharov, P. Kuzmichev, A. V. Rogachev, P. Buslaev, V. Borshchevskiy, A. Mishin, G. V. Dhoke, U. Schwaneberg, M. D. Davari, K. E. Jaeger, U. Krauss, V. Gordeliy and I. Gushchin
|
Photochem Photobiol Sci | 2019 | To publication |
|
Anchor Peptide-Mediated Surface Immobilization of a Grubbs-Hoveyda-Type Catalyst for Ring-Opening Metathesis Polymerization
A. R. S. Grimm, D. F.; Garakani, T. M.; Rubsam, K.; Polen, T.; Davari, M. D.; Jakob, F.; Schiffels, J.; Okuda, J.; Schwaneberg, U.
|
Bioconjugate Chemistry | 2019 | To publication |
|
Biadhesive Peptides for Assembling Stainless Steel and Compound Loaded Micro-Containers
L. Apitius, S. Buschmann, C. Bergs, D. Schonauer, F. Jakob, A. Pich and U. Schwaneberg
|
Macromol Biosci | 2019 | To publication |
|
Biocatalyst Immobilization by Anchor Peptides on an Additively Manufacturable Material
N. Büscher, G. V. Sayoga, K. Rübsam, F. Jakob, U. Schwaneberg, S. Kara and A. Liese
|
Organic Process Research & Development | 2019 | To publication |
|
Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein
D. F. Q. Sauer, Y.; Mertens, M. A. S.; Schiffels, J.; Polen, T.; Schwaneberg, U.; Okuda, J.
|
Catalysis Science & Technology | 2019 | To publication |
|
Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease
M. A. S. Mertens, D. F. Sauer, U. Markel, J. Schiffels, J. Okuda and U. Schwaneberg
|
Catalysis Science & Technology | 2019 | To publication |
|
Chiral separation of D/L-arginine with whole cells through an engineered FhuA nanochannel
D. Anand, G. V. Dhoke, J. Gehrmann, T. M. Garakani, M. D. Davari, M. Bocola, L. L. Zhua and U. Schwaneberg
|
Chemical Communications | 2019 | To publication |
|
Computer-assisted Recombination (CompassR) teaches us how to recombine beneficial substitutions from directed evolution campaigns
H. Cui, H. Cao, H. Cai, J. Karl-Erich, M. D. Davari and U. Schwaneberg
|
Chemistry – A European Journal | 2019 | To publication |
|
Consensus model of a cyanobacterial light-dependent protochlorophyllide oxidoreductase in its pigment-free apo-form and photoactive ternary complex
J. Schneidewind, F. Krause, M. Bocola, A. M. Stadler, M. D. Davari, U. Schwaneberg, K.-E. Jaeger and U. Krauss
|
Communications Biology | 2019 | To publication |