The work of the Herrmann group deals with bioorganic hybrid structures and genetically engineered biomacromolecules for various medical and technological applications. In particular, we pioneered two classes of materials, i.e. DNA-polymer conjugates and supercharged polypeptides. These materials are fabricated by integrating tools from organic- and polymer chemistry as well as from molecular biology. For evolving complex functions and interactive material properties, the accurate assembly of different building blocks into well-defined nanoscopic aggregates is an important requirement. For their characterization various nanotechnology tools like scanning force microscopy, transmission electron microscopy and fluorescence-based techniques are utilized. Finally, the interactions of the assemblies with living matter are explored, e.g. in the context of advanced drug delivery vehicles reacting to external stimuli like ultrasound. Other applications are diagnostic and nano-bio-electronic devices, genetic circuits or the bottom-up construction of proto-cells.
Team
Projects
Publications
| Titel/Autoren | Magazine | Jahre | |
|---|---|---|---|
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Activation of Antibiotic-Grafted Polymer Brushes
M. Zou, P. Zhao, S. Huo, R. Göstl and A. Herrmann
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ACS Macro Letters | 2021 | Zur Publikation |
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Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound
P. Zhao, S. Huo, J. Fan, J. Chen, F. Kiessling, A. J. Boersma, R. Göstl and A. Herrmann
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Angewandte Chemie International Edition | 2021 | Zur Publikation |
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Artificial Phase-Transitional Underwater Bioglue with Robust and Switchable Adhesion Performance
L. Xiao, Z. Wang, Y. Sun, B. Li, B. Wu, C. Ma, V. S. Petrovskii, X. Gu, D. Chen, I. I. Potemkin, A. Herrmann, H. Zhang and K. Liu
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Angewandte Chemie International Edition | 2021 | Zur Publikation |
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Bedeutung Von Makromolekülen Im Kampf Gegen Das Coronavirus
J. Köhler, A. Thoma, S. Braun, A. Pich and A. Herrmann
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Chemie in unserer Zeit | 2021 | Zur Publikation |
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Carrier-Free Micellar Cpg Interacting with Cell Membrane for Enhanced Immunological Treatment of Hiv-1
H. Kim, W. Zhang, J. Hwang, E.-K. An, Y. K. Choi, E. Moon, M. Loznik, Y. H. Huh, A. Herrmann, M. Kwak and J.-O. Jin
|
Biomaterials | 2021 | Zur Publikation |
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Characterization of Fluorescent Proteins with Intramolecular Photostabilization**
S. S. Henrikus, K. Tassis, L. Zhang, J. H. M. van der Velde, C. Gebhardt, A. Herrmann, G. Jung and T. Cordes
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ChemBioChem | 2021 | Zur Publikation |
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Dynamic DNA-Based Biomaterials Interacting with External, Macroscopic, and Molecular Stimuli
S. Huo, M. Kwak, J. Qin, B. Dittrichn and A. Herrmann
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Materials Today | 2021 | Zur Publikation |
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Fullerenes Enhance Self-Assembly and Electron Injection of Photosystem I in Biophotovoltaic Devices
N. Torabi, X. Qiu, M. López-Ortiz, M. Loznik, A. Herrmann, A. Kermanpur, A. Ashrafi and R. C. Chiechi
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Langmuir | 2021 | Zur Publikation |
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Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications
J. Sun, L. Xiao, B. Li, K. Zhao, Z. Wang, Y. Zhou, C. Ma, J. Li, H. Zhang, A. Herrmann and K. Liu
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Angewandte Chemie International Edition | 2021 | Zur Publikation |
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Highly Stiff and Stretchable DNA Liquid Crystalline Organogels with Super Plasticity, Ultrafast Self-Healing, and Magnetic Response Behaviors
Z. Meng, Q. Liu, Y. Zhang, J. Sun, C. Yang, H. Li, M. Loznik, R. Göstl, D. Chen, F. Wang, N. A. Clark, H. Zhang, A. Herrmann and K. Liu
|
Advanced Materials | 2021 | Zur Publikation |
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Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles
S. Schnichels, J. Hurst, J. W. de Vries, S. Ullah, K. Frößl, A. Gruszka, M. Löscher, K.-U. Bartz-Schmidt, M. S. Spitzer and A. Herrmann
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ACS Applied Materials & Interfaces | 2021 | Zur Publikation |
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Mechanochemical bond scission for the activation of drugs
S. Huo, P. Zhao, Z. Shi, M. Zou, X. Yang, E. Warszawik, M. Loznik, R. Göstl and A. Herrmann
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Nature Chemistry | 2021 | Zur Publikation |