The work of the Herrmann group deals with bioorganic hybrid structures and genetically engineered biomacromolecules for various medical and technological applications. In particular, we pioneered two classes of materials, i.e. DNA-polymer conjugates and supercharged polypeptides. These materials are fabricated by integrating tools from organic- and polymer chemistry as well as from molecular biology. For evolving complex functions and interactive material properties, the accurate assembly of different building blocks into well-defined nanoscopic aggregates is an important requirement. For their characterization various nanotechnology tools like scanning force microscopy, transmission electron microscopy and fluorescence-based techniques are utilized. Finally, the interactions of the assemblies with living matter are explored, e.g. in the context of advanced drug delivery vehicles reacting to external stimuli like ultrasound. Other applications are diagnostic and nano-bio-electronic devices, genetic circuits or the bottom-up construction of proto-cells.
Team
Projects
Publications
| Titel/Autoren | Magazine | Jahre | |
|---|---|---|---|
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Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles
S. Schnichels, J. Hurst, J. W. de Vries, S. Ullah, K. Frößl, A. Gruszka, M. Löscher, K.-U. Bartz-Schmidt, M. S. Spitzer and A. Herrmann
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ACS Applied Materials & Interfaces | 2021 | Zur Publikation |
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Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles
S. Schnichels, J. Hurst, J. W. de Vries, S. Ullah, K. Frößl, A. Gruszka, M. Löscher, K.-U. Bartz-Schmidt, M. S. Spitzer and A. Herrmann
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ACS Applied Materials & Interfaces | 2021 | Zur Publikation |
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Mechanochemical bond scission for the activation of drugs
S. Huo, P. Zhao, Z. Shi, M. Zou, X. Yang, E. Warszawik, M. Loznik, R. Göstl and A. Herrmann
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Nature Chemistry | 2021 | Zur Publikation |
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Photochemical control of bacterial gene expression based on trans encoded genetic switches
A. Paul, J. Huang, Y. Han, X. Yang, L. Vuković, P. Král, L. Zheng and A. Herrmann
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Chemical Science | 2021 | Zur Publikation |
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Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B
A. A. Bastian, A. Gruszka, P. Jung and A. Herrmann
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Organic & Biomolecular Chemistry | 2020 | Zur Publikation |
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Controlling Optical and Catalytic Activity of Genetically Engineered Proteins by Ultrasound
Y. Zhou, S. Huo, M. Loznik, R. Göstl, A. J. Boersma and A. Herrmann
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Angewandte Chemie International Edition | 2020 | Zur Publikation |
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De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane
C. Ma, J. Dong, M. Viviani, I. Tulini, N. Pontillo, S. Maity, Y. Zhou, W. H. Roos, K. Liu, A. Herrmann and G. Portale
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Science Advances | 2020 | Zur Publikation |
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Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release
Z. Shi, Q. Song, R. Göstl and A. Herrmann
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Chemical Science | 2020 | Zur Publikation |
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Modular and Versatile Trans-Encoded Genetic Switches
A. Paul, E. M. Warszawik, M. Loznik, A. J. Boersma and A. Herrmann
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Angewandte Chemie International Edition | 2020 | Zur Publikation |
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Next Generation Salivary Lubrication Enhancer Derived from Recombinant Supercharged Polypeptides for Xerostomia
H. Wan, C. Ma, J. Vinke, A. Vissink, A. Herrmann and P. K. Sharma
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Acs Applied Materials & Interfaces | 2020 | Zur Publikation |
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Reversibly Photo-Modulating Mechanical Stiffness and Toughness of Bioengineered Protein Fibers
J. Sun, C. Ma, S. Maity, F. Wang, Y. Zhou, G. Portale, R. Göstl, W. H. Roos, H. Zhang, K. Liu and A. Herrmann
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Angewandte Chemie International Edition | 2020 | Zur Publikation |
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Self-assembled DNA nanoparticles loaded with travoprost for glaucoma-treatment
S. Schnichels, J. Hurst, J. W. de Vries, S. Ullah, A. Gruszka, M. Kwak, M. Loscher, S. Dammeier, K. U. Bartz-Schmidt, M. S. Spitzer and A. Herrmann
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Nanomedicine-Nanotechnology Biology and Medicine | 2020 | Zur Publikation |