The work of the Herrmann group deals with bioorganic hybrid structures and genetically engineered biomacromolecules for various medical and technological applications. In particular, we pioneered two classes of materials, i.e. DNA-polymer conjugates and supercharged polypeptides. These materials are fabricated by integrating tools from organic- and polymer chemistry as well as from molecular biology. For evolving complex functions and interactive material properties, the accurate assembly of different building blocks into well-defined nanoscopic aggregates is an important requirement. For their characterization various nanotechnology tools like scanning force microscopy, transmission electron microscopy and fluorescence-based techniques are utilized. Finally, the interactions of the assemblies with living matter are explored, e.g. in the context of advanced drug delivery vehicles reacting to external stimuli like ultrasound. Other applications are diagnostic and nano-bio-electronic devices, genetic circuits or the bottom-up construction of proto-cells.
Team
Projects
Publications
| Title/authors | Magazine | Year | |
|---|---|---|---|
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De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane
C. Ma, J. Dong, M. Viviani, I. Tulini, N. Pontillo, S. Maity, Y. Zhou, W. H. Roos, K. Liu, A. Herrmann and G. Portale
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Science Advances | 2020 | |
|
Engineered Near‐Infrared Fluorescent Protein Assemblies for Robust Bioimaging and Therapeutic Applications
J. Li, B. Li, J. Sun, C. Ma, S. Wan, Y. Li, R. Göstl, A. Herrmann, K. Liu, H. Zhang
|
Advanced Materials | 2020 | To publication |
|
Modular and Versatile Trans-Encoded Genetic Switches
A. Paul, E. M. Warszawik, M. Loznik, A. J. Boersma and A. Herrmann
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Angewandte Chemie International Edition | 2020 | To publication |
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Solvent-Free Plasticity and Programmable Mechanical Behaviors of Engineered Proteins
C. Ma, J. Su, B. Li, A. Herrmann, H. Zhang, K, Liu
|
Advanced Materials | 2020 | To publication |
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Supercharged Proteins and Polypeptides
C. Ma, A. Malessa, A. Boersma, K. Liu, A. Herrmann
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Advanced Materials | 2020 | To publication |
|
Anti-Stokes Stress Sensing: Mechanochemical Activation of Triplet-Triplet Annihilation Photon Upconversion
D. Yildiz, C. Baumann, A. Mikosch, A. J. C. Kuehne, A. Herrmann and R. Göstl
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Angew Chem Int Ed Engl | 2019 | To publication |
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Brimonidine loaded lipid DNA-nanoparticles as an improved and novel treatment option for glaucoma
S. Schnichels, K. Frossl, J. W. de Vries, M. Loscher, K. Bartz-Schmidt, A. Herrmann, M. S. Spitzer and J. Hurst
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Investigative Ophthalmology & Visual Science | 2019 | |
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ColiCoords: A Python package for the analysis of bacterial fluorescence microscopy data
J. H. Smit, Y. Li, E. M. Warszawik, A. Herrmann and T. Cordes
|
PLoS One | 2019 | To publication |
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DNA Nanotechnology Enters Cell Membranes
S. Huo, H. Li, A. J. Boersma and A. Herrmann
|
Advanced Science | 2019 | To publication |
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Electrostatically PEGylated DNA enables salt-free hybridization in water
G. Chakraborty, K. Balinin, G. Portale, M. Loznik, E. Polushkin, T. Weil, A. Herrmann
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Chemical Science | 2019 | To publication |
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Fabrication and Mechanical Properties of Engineered Protein-Based Adhesives and Fibers
J. Sun, J. J. Su, C. Ma, R. Gostl, A. Herrmann, K. Liu and H. J. Zhang
|
Advanced Materials | 2019 | To publication |
|
Fast, Efficient, and Targeted Liposome Delivery Mediated by DNA Hybridization
H. Li, Q. Liu, B. J. Crielaard, J. W. de Vries, M. Loznik, Z. Meng, X. Yang, R. Göstl and A. Herrmann
|
Adv Healthc Mater | 2019 | To publication |