The work of the Herrmann group deals with bioorganic hybrid structures and genetically engineered biomacromolecules for various medical and technological applications. In particular, we pioneered two classes of materials, i.e. DNA-polymer conjugates and supercharged polypeptides. These materials are fabricated by integrating tools from organic- and polymer chemistry as well as from molecular biology. For evolving complex functions and interactive material properties, the accurate assembly of different building blocks into well-defined nanoscopic aggregates is an important requirement. For their characterization various nanotechnology tools like scanning force microscopy, transmission electron microscopy and fluorescence-based techniques are utilized. Finally, the interactions of the assemblies with living matter are explored, e.g. in the context of advanced drug delivery vehicles reacting to external stimuli like ultrasound. Other applications are diagnostic and nano-bio-electronic devices, genetic circuits or the bottom-up construction of proto-cells.
Team
Projects
Publications
| Titel/Autoren | Magazine | Jahre | |
|---|---|---|---|
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Animal Fiber Identification under the Open Set Condition
O. Rippel, S. Gülçelik, K. Rahimi, J. Kurniadi, A. Herrmann, D. Merhof
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Proceedings of the 17th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications | 2022 | |
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Force Ahead: Emerging Applications and Opportunities of Polymer Mechanochemistry
H.-A. Klok, A. Herrmann and R. Göstl
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ACS Polymers Au | 2022 | |
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Ionic Combisomes: A New Class of Biomimetic Vesicles to Fuse with Life
A. M. Wagner, J. Quandt, D. Söder, M. Garay-Sarmiento, A. Joseph, V. S. Petrovskii, L. Witzdam, T. Hammoor, P. Steitz, T. Haraszti, I. I. Potemkin, N. Y. Kostina, A. Herrmann and C. Rodriguez-Emmenegger
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Advanced Science | 2022 | |
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Late-Stage Modification of Aminoglycoside Antibiotics Overcomes Bacterial Resistance Mediated by Aph(3’) Kinases
A. A. Bastian, M. Bastian, M. Jäger, M. Loznik, E. M. Warszawik, X. Yang, N. Tahiri, P. Fodran, M. D. Witte, A. Thoma, J. Köhler, A. J. Minnaard and A. Herrmann
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Chemistry – A European Journal | 2022 | |
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Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes During Bio-Labeling
L. Zhang, M. Isselstein, J. Köhler, N. Eleftheriadis, N. Huisjes, M. Guirao, A. Narducci, J. Smit, J. Stoffels, H. Harz, H. Leonhardt, A. Herrmann and T. Cordes
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Angewandte Chemie International Edition | 2022 | |
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Mechano-Nanoswitches for Ultrasound-Controlled Drug Activation
S. Huo, Z. Liao, P. Zhao, Y. Zhou, R. Göstl and A. Herrmann
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Advanced Science | 2022 | |
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Microgels as Drug Carriers for Sonopharmacology
M. Zou, P. Zhao, J. Fan, R. Göstl and A. Herrmann
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Journal of Polymer Science | 2022 | |
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The Mechanochemical Synthesis and Activation of Carbon-Rich π-Conjugated Materials
M. Xuan, C. Schumacher, C. Bolm, R. Göstl and A. Herrmann
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Advanced Science | 2022 | |
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Activation of Antibiotic-Grafted Polymer Brushes
M. Zou, P. Zhao, S. Huo, R. Göstl and A. Herrmann
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ACS Macro Letters | 2021 | |
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Activation of Antibiotic-Grafted Polymer Brushes by Ultrasound
M. Zou, P. Zhao, S. Huo, R. Göstl and A. Herrmann
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ACS Macro Letters | 2021 | |
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Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound
P. Zhao, S. Huo, J. Fan, J. Chen, F. Kiessling, A. J. Boersma, R. Göstl and A. Herrmann
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Angewandte Chemie International Edition | 2021 | |
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Artificial Phase-Transitional Underwater Bioglue with Robust and Switchable Adhesion Performance
L. Xiao, Z. Wang, Y. Sun, B. Li, B. Wu, C. Ma, V. S. Petrovskii, X. Gu, D. Chen, I. I. Potemkin, A. Herrmann, H. Zhang and K. Liu
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Angewandte Chemie International Edition | 2021 |