The research of our group focuses on synthetic chemistry and molecular biology. Chemists, biologists and physicists are dedicated to the task of inventing new molecular technologies to create new (bio)molecular and biohybrid structures by combining chemical and biological processes. Our group has pioneered the development of two classes of materials: nucleic acid polymer conjugates and supercharged polypeptides. Inspired by nature, these materials are designed to form well-defined molecular architectures that span multiple length scales from nanometer to macroscopic structures. These structures are key for the realization of complex functions in technological, medical and life science applications.
Sonopharmacology: Our group was the first to transfer concepts from polymer mechanochemistry to the life sciences. Ultrasound and the resulting shear forces in aqueous environment act as external trigger to activate different classes of drug molecules realizing a novel concept for precision targeting medicines.
D. Yiliz, R. Göstl & A. Herrmann: Chem. Sci. 2022, 13: 13708-13719
S. Huo et al.: Nat. Chem. 2021, 13: 131-139
Sonogenetics: Besides switching on active pharmaceutical ingredients by ultrasound, we exploit this trigger to manipulate the activity of proteins and genes. Enzymes and nucleic acids are designed to respond to low intensity biocompatible ultrasound to remotely orchestrate biological systems deep inside the body in the future.
P. Zhao et al.: Angew. Chem. Int. Ed. 2021, 60(26): 14707-14714
Y. Zhou et al.: Angew. Chem. Int. Ed. 2021, 60(3): 1493-1497
Ultrastrong Bioadhesives: We design molecular glues de novo by exploiting recombinant protein expression and genetic engineering. Supercharged polypeptides were complexed with surfactants to form coacervate-based adhesives with outstanding features such as temperature switchability, hemostatic and wound healing promoting properties.
Y. Zhou et al.: Adv. Mater. 2023, 35(16): 2210052
C. Ma et al.: Nat. Commun. 2021, 12: 3613
Team
Projects
Publications
| Titel/Autoren | DOI-LINK | Magazine | Jahre | |
|---|---|---|---|---|
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Fracture Detection in Bio-Glues with Fluorescent-Protein-Based Optical Force Probes
Y. Zhou, S. P. Centeno, K. Zhang, L. Zheng, R. Göstl and A. Herrmann
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https://doi.org/10.1002/adma.202210052 | Advanced Materials | 2023 | |
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Fracture Detection in Bio-Glues with Fluorescent-Protein-Based Optical Force Probes
Y. Zhou, S. P. Centeno, K. Zhang, L. Zheng, R. Göstl and A. Herrmann
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https://doi.org/10.1002/adma.202210052 | Advanced Materials | 2023 | |
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Lipid-DNA Nanoparticles as Drug-Delivery Vehicles for the Treatment of Retinal Diseases
S. Schnichels, D. Simmang, M. Löscher, A. Herrmann, J. W. de Vries, M. S. Spitzer and J. Hurst
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https://doi.org/10.3390/pharmaceutics15020532 | Pharmaceutics | 2023 | |
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Nanopore Detection Using Supercharged Polypeptide Molecular Carriers
X. Wang, T.-M. Thomas, R. Ren, Y. Zhou, P. Zhang, J. Li, S. Cai, K. Liu, A. P. Ivanov, A. Herrmann and J. B. Edel
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https://doi.org/10.1021/jacs.2c13465 | Journal of the American Chemical Society | 2023 | |
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Protein Orientation Defines Rectification of Electronic Current Via Solid-State Junction of Entire Photosystem-1 Complex
J. A. Fereiro, T. Bendikov, A. Herrmann, I. Pecht, M. Sheves and D. Cahen
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https://doi.org/10.1021/jacs.2c13465 | The Journal of Physical Chemistry Letters | 2023 | |
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Transformative Materials for Interfacial Drug Delivery
P. Desai, A. Dasgupta, A. M. Sofias, Q. Peña, R. Göstl, I. Slabu, U. Schwaneberg, T. Stiehl, W. Wagner, S. Jockenhövel, J. Stingl, R. Kramann, C. Trautwein, T. H. Brümmendorf, F. Kiessling, A. Herrmann and T. Lammers
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https://doi.org/10.1002/adhm.202301062 | Advanced Healthcare Materials | 2023 | |
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Transformative Materials to Create 3D Functional Human Tissue Models in Vitro in a Reproducible Manner
J. L. Gerardo-Nava, J. Jansen, D. Günther, L. Klasen, A. L. Thiebes, B. Niessing, C. Bergerbit, A. A. Meyer, J. Linkhorst, M. Barth, P. Akhyari, J. Stingl, S. Nagel, T. Stiehl, A. Lampert, R. Leube, M. Wessling, F. Santoro, S. Ingebrandt, S. Jockenhoevel, A. Herrmann, H. Fischer, W. Wagner, R. H. Schmitt, F. Kiessling, R. Kramann and L. De Laporte
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https://doi.org/10.1002/adhm.202301030 | Advanced Healthcare Materials | 2023 | |
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Animal Fiber Identification under the Open Set Condition
O. Rippel, S. Gülçelik, K. Rahimi, J. Kurniadi, A. Herrmann, D. Merhof
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https://doi.org/10.5220/0010769800003124 | Proceedings of the 17th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications | 2022 | |
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Force Ahead: Emerging Applications and Opportunities of Polymer Mechanochemistry
H.-A. Klok, A. Herrmann and R. Göstl
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https://doi.org/10.1021/acspolymersau.2c00029 | ACS Polymers Au | 2022 | |
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Ionic Combisomes: A New Class of Biomimetic Vesicles to Fuse with Life
A. M. Wagner, J. Quandt, D. Söder, M. Garay-Sarmiento, A. Joseph, V. S. Petrovskii, L. Witzdam, T. Hammoor, P. Steitz, T. Haraszti, I. I. Potemkin, N. Y. Kostina, A. Herrmann and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/advs.202200617 | Advanced Science | 2022 | |
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Late-Stage Modification of Aminoglycoside Antibiotics Overcomes Bacterial Resistance Mediated by APH(3’) Kinases
A. A. Bastian, M. Bastian, M. Jäger, M. Loznik, E. M. Warszawik, X. Yang, N. Tahiri, P. Fodran, M. D. Witte, A. Thoma, J. Köhler, A. J. Minnaard and A. Herrmann
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https://doi.org/10.1002/chem.202200883 | Chemistry – A European Journal | 2022 | |
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Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes During Bio-Labeling
L. Zhang, M. Isselstein, J. Köhler, N. Eleftheriadis, N. Huisjes, M. Guirao, A. Narducci, J. Smit, J. Stoffels, H. Harz, H. Leonhardt, A. Herrmann and T. Cordes
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https://doi.org/10.1002/anie.202112959 | Angewandte Chemie International Edition | 2022 |