The group of Prof. Dr.-Ing. Laura De Laporte designs biomaterial systems for Advance Medical Systems in the field of Tissue Engineering. Cellular guidance is essential for life in multicellularity but it remains challenging to build biomaterial constructs with a native-like extracellular matrix structure and architecture, including spatiotemporal control over bio-functional domains and mechanical gradients. To study cellular processes involved in tissue formation and diseases, we apply polymeric molecular and nano- to micron-scale building blocks to assemble into soft 3D biomimetic constructs in a bottom-up manner. Hydrogels are designed with structural variations on different length scales, while the time scales have to be accounted for due to alterations upon the interaction with living cells. A better understanding of cellular processes depending on the properties and dynamics of synthetic biomaterials supplies information about the material parameters, which are most important to grow viable and functional regenerative materials for clinical use and ex vivo tissue models.
Prof. Dr.-Ing. Laura De Laporte
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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A catalyst-free, temperature controlled gelation system for in-mold fabrication of microgels
A. J. D. Kruger, J. Kohler, S. Cichosz, J. C. Rose, D. B. Gehlen, T. Haraszti, M. Moller and L. De Laporte
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https://www.dwi.rwth-aachen.de/files/redaktion/Publikationen/A%20catalyst-free%2C%20temperature%20controlled%20gelation%20system%20for%20in%20mold%20fabrication%20of%20microgels.pdf | Chemical Communications | 2018 | |
A Layer-by-Layer Single-Cell Coating Technique To Produce Injectable Beating Mini Heart Tissues via Microfluidics
L. P. B. Guerzoni, Y. Tsukamoto, D. B. Gehlen, D. Rommel, T. Haraszti, M. Akashi, L. De Laporte
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https://doi.org/10.1021/acs.biomac.9b00786 | Biomacromolecules | 2019 | |
A water-soluble PEGylated RGD-functionalized bisbithiophenyl diketopyrrolopyrrole as a photoacoustic sonophore
T. Repenko, A. Rix, B. Haehnle, W. Lederle, L. De Laporte and A. J. C. Kuehne
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https://www.doi.org/10.1039/c8pp00069g | Photochemical & Photobiological Sciences | 2018 | |
Actuation of Soft Thermoresponsive Hydrogels Mechanically Stimulates Osteogenesis in Human Mesenchymal Stem Cells without Biochemical Factors
A. Castro Nava, I. C. Doolaar, N. Labude-Weber, H. Malyaran, S. Babu, Y. Chandorkar, J. Di Russo, S. Neuss and L. De Laporte
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https://doi.org/10.1021/acsami.3c11808 | ACS Applied Materials & Interfaces | 2023 | |
An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells
A. Omidinia-Anarkoli, S. Boesveld, U. Tuvshindorj, J. C. Rose, T. Haraszti and L. De Laporte
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https://www.doi.org/10.1002/smll.201702207 | Small | 2017 | |
Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment
S. Vedaraman, A. Perez-Tirado, T. Haraszti, J. Gerardo-Nava, A. Nishiguchi and L. De Laporte
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https://doi.org/10.1002/adhm.202100874 | Advanced Healthcare Materials | 2021 | |
Annealing High Aspect Ratio Microgels into Macroporous 3D Scaffolds Allows for Higher Porosities and Effective Cell Migration
A. C. Suturin, A. J. D. Krüger, K. Neidig, N. Klos, N. Dolfen, M. Bund, T. Gronemann, R. Sebers, A. Manukanc, G. Yazdani, Y. Kittel, D. Rommel, T. Haraszti, J. Köhler and L. De Laporte
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https://doi.org/10.1002/adhm.202200989 | Advanced Healthcare Materials | 2022 | |
Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels
S. Vedaraman, D. Bernhagen, T. Haraszti, C. Licht, A. Castro Nava, A. Omidinia Anarkoli, P. Timmerman and L. De Laporte
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https://doi.org/10.1039/D0BM02051F | Biomaterials Science | 2021 | |
Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering
J. G. Torres-Rendon, T. Femmer, L. De Laporte, T. Tigges, K. Rahimi, F. Gremse, S. Zafarnia, W. Lederle, S. Ifuku, M. Wessling, J. G. Hardy and A. Walther
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https://www.doi.org/10.1002/adma.201405873 | Adv Mater | 2015 | |
Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
J. C. Rose, D. B. Gehlen, T. H. J. Kohler, C. J. Licht and L. De Laporte
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https://www.doi.org/10.1016/j.biomaterials.2018.02.001 | Biomaterials | 2018 | |
Call for Special Issue Papers: Special Issue for Prof. James Kirkpatrick in Honor of His Achievements in Tissue Engineering/Regenerative Medicine
L. De Laporte and J. van den Beucken
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https://doi.org/10.1089/ten.tea.2023.29050.cfp | Tissue Eng Part A | 2023 | |
Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System
L. P. B. Guerzoni, J. C. Rose, D. B. Gehlen, A. Jans, T. Haraszti, M. Wessling, A. J. C. Kuehne and L. De Laporte
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https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201900692 | Small | 2019 |