The group of Prof. Dr.-Ing. Laura De Laporte designs biomaterial systems for Advance Medical Systems in the field of Tissue Engineering. Cellular guidance is essential for life in multicellularity but it remains challenging to build biomaterial constructs with a native-like extracellular matrix structure and architecture, including spatiotemporal control over bio-functional domains and mechanical gradients. To study cellular processes involved in tissue formation and diseases, we apply polymeric molecular and nano- to micron-scale building blocks to assemble into soft 3D biomimetic constructs in a bottom-up manner. Hydrogels are designed with structural variations on different length scales, while the time scales have to be accounted for due to alterations upon the interaction with living cells. A better understanding of cellular processes depending on the properties and dynamics of synthetic biomaterials supplies information about the material parameters, which are most important to grow viable and functional regenerative materials for clinical use and ex vivo tissue models.
Prof. Dr.-Ing. Laura De Laporte
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Rapid and Robust Coating Method to Render Polydimethylsiloxane Surfaces Cell-Adhesive
D. B. Gehlen, L. C. De Lencastre Novaes, W. Long, A. J. Ruff, F. Jakob, T. Haraszti, Y. Chandorkar, L. Yang, P. van Rijn, U. Schwaneberg and L. De Laporte
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https://www.doi.org/10.1021/acsami.9b16025 | ACS Appl Mater Interfaces | 2019 | |
Actuation of Soft Thermoresponsive Hydrogels Mechanically Stimulates Osteogenesis in Human Mesenchymal Stem Cells without Biochemical Factors
A. Castro Nava, I. C. Doolaar, N. Labude-Weber, H. Malyaran, S. Babu, Y. Chandorkar, J. Di Russo, S. Neuss and L. De Laporte
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https://doi.org/10.1021/acsami.3c11808 | ACS Applied Materials & Interfaces | 2023 | |
Cell Guiding Multicomponent Nanoyarn Tendon Scaffolds with Tunable Morphology and Flexibility
L. Schynkel, M. Meeremans, A. A. Meyer, E. Schoolaert, J. Geltmeyer, A. Omidinia-Anarkoli, S. Van Vlierberghe, L. Daelemans, L. De Laporte, C. De Schauwer, R. Hoogenboom and K. De Clerck
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https://doi.org/10.1021/acsami.3c08241 | ACS Applied Materials & Interfaces | 2023 | |
Metal-Organic Gels Based on a Bisamide Tetracarboxyl Ligand for Carbon Dioxide, Sulfur Dioxide, and Selective Dye Uptake
D. Dietrich, C. Licht, A. Nuhnen, S. P. Hofert, L. De Laporte and C. Janiak
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https://pubs.acs.org/doi/full/10.1021/acsami.9b04659 | ACS Applied Materials & Interfaces | 2019 | |
Solvent-Induced Nanotopographies of Single Microfibers Regulate Cell Mechanotransduction
A. Omidinia-Anarkoli, R. Rimal, Y. Chandorkar, D. B. Gehlen, J. C. Rose, K. Rahimi, T. Haraszti and L. De Laporte
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https://www.doi.org/10.1021/acsami.8b17955 | Acs Applied Materials & Interfaces | 2019 | |
Enhanced Stable Cavitation and Nonlinear Acoustic Properties of Poly(Butyl Cyanoacrylate) Polymeric Microbubbles after Bioconjugation
R. A. Barmin, A. Dasgupta, A. Rix, M. Weiler, L. Appold, S. Rütten, F. Padilla, A. J. C. Kuehne, A. Pich, L. De Laporte, F. Kiessling, R. M. Pallares and T. Lammers
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https://doi.org/10.1021/acsbiomaterials.2c01021 | ACS Biomaterials Science & Engineering | 2022 | |
Hierarchical fibrous guiding cues at different scales influence linear neurite extension
A. Omidinia-Anarkoli, J. W. Ephraim, R. Rimal and L. De Laporte
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https://doi.org/10.1016/j.actbio.2020.07.014 | Acta Biomaterialia | 2020 | |
Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering
J. G. Torres-Rendon, T. Femmer, L. De Laporte, T. Tigges, K. Rahimi, F. Gremse, S. Zafarnia, W. Lederle, S. Ifuku, M. Wessling, J. G. Hardy and A. Walther
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https://www.doi.org/10.1002/adma.201405873 | Adv Mater | 2015 | |
How do the Local Physical, Biochemical, and Mechanical Properties of an Injectable Synthetic Anisotropic Hydrogel Affect Oriented Nerve Growth?
S. Babu, I. Chen, S. Vedaraman, J. Gerardo-Nava, C. Licht, Y. Kittel, T. Haraszti, J. Di Russo and L. De Laporte
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https://doi.org/10.1002/adfm.202202468 | Advanced Functional Materials | 2022 | |
Pre-Programmed Rod-Shaped Microgels to Create Multi-Directional Anisogels for 3d Tissue Engineering
D. L. Braunmiller, S. Babu, D. B. Gehlen, M. Seuß, T. Haraszti, A. Falkenstein, J. Eigen, L. De Laporte and J. J. Crassous
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https://doi.org/10.1002/adfm.202202430 | Advanced Functional Materials | 2022 | |
Strong Photoacoustic Signal Enhancement by Coating Gold Nanoparticles with Melanin for Biomedical Imaging
T. Repenko, A. Rix, A. Nedilko, J. Rose, A. Hermann, R. Vinokur, S. Moli, R. Cao-Milan, M. Mayer, G. von Plessen, A. Fery, L. De Laporte, W. Lederle, D. N. Chigrin and A. J. C. Kuehne
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https://www.doi.org/10.1002/adfm.201705607 | Advanced Functional Materials | 2018 | |
Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment
S. Vedaraman, A. Perez-Tirado, T. Haraszti, J. Gerardo-Nava, A. Nishiguchi and L. De Laporte
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https://doi.org/10.1002/adhm.202100874 | Advanced Healthcare Materials | 2021 |