The group of Prof. Dr.-Ing. Laura De Laporte designs biomaterial systems for Advance Medical Systems in the field of Tissue Engineering. Cellular guidance is essential for life in multicellularity but it remains challenging to build biomaterial constructs with a native-like extracellular matrix structure and architecture, including spatiotemporal control over bio-functional domains and mechanical gradients. To study cellular processes involved in tissue formation and diseases, we apply polymeric molecular and nano- to micron-scale building blocks to assemble into soft 3D biomimetic constructs in a bottom-up manner. Hydrogels are designed with structural variations on different length scales, while the time scales have to be accounted for due to alterations upon the interaction with living cells. A better understanding of cellular processes depending on the properties and dynamics of synthetic biomaterials supplies information about the material parameters, which are most important to grow viable and functional regenerative materials for clinical use and ex vivo tissue models.
Prof. Dr.-Ing. Laura De Laporte
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering
J. G. Torres-Rendon, T. Femmer, L. De Laporte, T. Tigges, K. Rahimi, F. Gremse, S. Zafarnia, W. Lederle, S. Ifuku, M. Wessling, J. G. Hardy and A. Walther
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https://www.doi.org/10.1002/adma.201405873 | Adv Mater | 2015 | |
Cellulose Nanofibril Hydrogel Tubes as Sacrificial Templates for Freestanding Tubular Cell Constructs
J. G. Torres-Rendon, M. Kopf, D. Gehlen, A. Blaeser, H. Fischer, L. De Laporte and A. Walther
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https://www.doi.org/10.1021/acs.biomac.5b01593 | Biomacromolecules | 2016 | |
An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells
A. Omidinia-Anarkoli, S. Boesveld, U. Tuvshindorj, J. C. Rose, T. Haraszti and L. De Laporte
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https://www.doi.org/10.1002/smll.201702207 | Small | 2017 | |
High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to alpha(v)beta(3), alpha(v)beta(5), and alpha(5)beta(1) Integrin Receptors
D. Bernhagen, L. De Laporte and P. Timmerman
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https://www.doi.org/10.1021/acs.analchem.7b00554 | Analytical Chemistry | 2017 | |
Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules
L. P. B. Guerzoni, J. Bohl, A. Jans, J. C. Rose, J. Koehler, A. J. C. Kuehne and L. De Laporte
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https://www.doi.org/10.1039/c7bm00322f | Biomaterials Science | 2017 | |
Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance
J. C. Rose, M. Camara-Torres, K. Rahimi, J. Kohler, M. Moller and L. De Laporte
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https://www.doi.org/10.1021/acs.nanolett.7b01123 | Nano Letters | 2017 | |
A catalyst-free, temperature controlled gelation system for in-mold fabrication of microgels
A. J. D. Kruger, J. Kohler, S. Cichosz, J. C. Rose, D. B. Gehlen, T. Haraszti, M. Moller and L. De Laporte
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https://www.dwi.rwth-aachen.de/files/redaktion/Publikationen/A%20catalyst-free%2C%20temperature%20controlled%20gelation%20system%20for%20in%20mold%20fabrication%20of%20microgels.pdf | Chemical Communications | 2018 | |
A water-soluble PEGylated RGD-functionalized bisbithiophenyl diketopyrrolopyrrole as a photoacoustic sonophore
T. Repenko, A. Rix, B. Haehnle, W. Lederle, L. De Laporte and A. J. C. Kuehne
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https://www.doi.org/10.1039/c8pp00069g | Photochemical & Photobiological Sciences | 2018 | |
Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
J. C. Rose, D. B. Gehlen, T. H. J. Kohler, C. J. Licht and L. De Laporte
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https://www.doi.org/10.1016/j.biomaterials.2018.02.001 | Biomaterials | 2018 | |
Engineering biofunctional in vitro vessel models using a multilayer bioprinting technique
J. Schoneberg, F. De Lorenzi, B. Theek, A. Blaeser, D. Rommel, A. J. C. Kühne, F. Kiessling and H. Fischer
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https://www.doi.org/10.1038/s41598-018-28715-0 | Scientific Reports | 2018 | |
Hierarchical Design of Tissue Regenerative Constructs
J. C. Rose and L. De Laporte
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https://www.doi.org/10.1002/adhm.201701067 | Advanced Healthcare Materials | 2018 | |
Strong Photoacoustic Signal Enhancement by Coating Gold Nanoparticles with Melanin for Biomedical Imaging
T. Repenko, A. Rix, A. Nedilko, J. Rose, A. Hermann, R. Vinokur, S. Moli, R. Cao-Milan, M. Mayer, G. von Plessen, A. Fery, L. De Laporte, W. Lederle, D. N. Chigrin and A. J. C. Kuehne
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https://www.doi.org/10.1002/adfm.201705607 | Advanced Functional Materials | 2018 |