The group of Prof. Dr.-Ing. Laura De Laporte designs biomaterial systems for Advance Medical Systems in the field of Tissue Engineering. Cellular guidance is essential for life in multicellularity but it remains challenging to build biomaterial constructs with a native-like extracellular matrix structure and architecture, including spatiotemporal control over bio-functional domains and mechanical gradients. To study cellular processes involved in tissue formation and diseases, we apply polymeric molecular and nano- to micron-scale building blocks to assemble into soft 3D biomimetic constructs in a bottom-up manner. Hydrogels are designed with structural variations on different length scales, while the time scales have to be accounted for due to alterations upon the interaction with living cells. A better understanding of cellular processes depending on the properties and dynamics of synthetic biomaterials supplies information about the material parameters, which are most important to grow viable and functional regenerative materials for clinical use and ex vivo tissue models.
Prof. Dr.-Ing. Laura De Laporte
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Call for Special Issue Papers: Special Issue for Prof. James Kirkpatrick in Honor of His Achievements in Tissue Engineering/Regenerative Medicine
L. De Laporte and J. van den Beucken
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https://doi.org/10.1089/ten.tea.2023.29050.cfp | Tissue Eng Part A | 2023 | |
On-Chip Fabrication of Colloidal Suprastructures by Assembly and Supramolecular Interlinking of Microgels
S.-H. Jung, F. Meyer, S. Hörnig, M. Bund, B. Häßel, L. P. B. Guerzoni, L. De Laporte, G. Ben Messaoud, S. P. Centeno and A. Pich
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https://doi.org/10.1002/smll.202303444 | Small | 2023 | |
Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System
L. P. B. Guerzoni, J. C. Rose, D. B. Gehlen, A. Jans, T. Haraszti, M. Wessling, A. J. C. Kuehne and L. De Laporte
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https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201900692 | Small | 2019 | |
An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells
A. Omidinia-Anarkoli, S. Boesveld, U. Tuvshindorj, J. C. Rose, T. Haraszti and L. De Laporte
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https://www.doi.org/10.1002/smll.201702207 | Small | 2017 | |
Unravelling colloid filter cake motions in membrane cleaning procedures
A. Lüken, J. Linkhorst, R. Fröhlingsdorf, L. Lippert, D. Rommel, L. De Laporte and M. Wessling
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https://doi.org/10.1038/s41598-020-76970-x | Scientific Reports | 2020 | |
Engineering biofunctional in vitro vessel models using a multilayer bioprinting technique
J. Schoneberg, F. De Lorenzi, B. Theek, A. Blaeser, D. Rommel, A. J. C. Kühne, F. Kiessling and H. Fischer
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https://www.doi.org/10.1038/s41598-018-28715-0 | Scientific Reports | 2018 | |
Nonspherical Ultrasound Microbubbles
A. Dasgupta, T. Sun, R. Palomba, E. Rama, Y. Zhang, C. Power, D. Moeckel, M. Liu, A. Sarode, M. Weiler, A. Motta, C. Porte, Z. Magnuska, A. Said Elshafei, R. Barmin, A. Graham, A. McClelland, D. Rommel, E. Stickeler, F. Kiessling, R. M. Pallares, L. De Laporte, P. Decuzzi, N. McDannold, S. Mitragotri and T. Lammers
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https://doi.org/10.1073/pnas.2218847120 | Proceedings of the National Academy of Sciences | 2023 | |
High-Throughput Production of Micrometer Sized Double Emulsions and Microgel Capsules in Parallelized 3D Printed Microfluidic Devices
A. Jans, J. Lolsberg, A. Omidinia-Anarkoli, R. Viermann, M. Möller, L. De Laporte, M. Wessling and A. J. C. Kühne
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https://www.doi.org/10.3390/polym11111887 | Polymers | 2019 | |
Predicting the orientation of magnetic microgel rods for soft anisotropic biomimetic hydrogels
J. C. Rose, M. Fölster, L. Kivilip, J. L. Gerardo-Nava, E. E. Jaekel, D. B. Gehlen, W. Rohlfs and L. De Laporte
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https://doi.org/10.1039/C9PY01008D | Polymer Chemistry | 2019 | |
A water-soluble PEGylated RGD-functionalized bisbithiophenyl diketopyrrolopyrrole as a photoacoustic sonophore
T. Repenko, A. Rix, B. Haehnle, W. Lederle, L. De Laporte and A. J. C. Kuehne
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https://www.doi.org/10.1039/c8pp00069g | Photochemical & Photobiological Sciences | 2018 | |
Cellular responses to beating hydrogels to investigate mechanotransduction
Y. Chandorkar, A. Castro Nava, S. Schweizerhof, M. Van Dongen, T. Haraszti, J. Köhler, H. Zhang, R. Windoffer, A. Mourran, M. Möller, L. De Laporte
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https://doi.org/10.1038/s41467-019-11475-4 | Nature Communications | 2019 | |
Nanofibers and Nanostructured Scaffolds for Nervous System Lesions
Jose L. Gerardo NavaEmail authorJonas C. RoseHaktan AltinovaPaul D. DaltonLaura De LaporteGary A. Brook
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https://doi.org/10.1007/978-1-0716-0838-8_3 | Nanomedicines for Brain Drug Delivery | 2020 |