The group of Prof. Dr.-Ing. Laura De Laporte designs biomaterial systems for Advance Medical Systems in the field of Tissue Engineering. Cellular guidance is essential for life in multicellularity but it remains challenging to build biomaterial constructs with a native-like extracellular matrix structure and architecture, including spatiotemporal control over bio-functional domains and mechanical gradients. To study cellular processes involved in tissue formation and diseases, we apply polymeric molecular and nano- to micron-scale building blocks to assemble into soft 3D biomimetic constructs in a bottom-up manner. Hydrogels are designed with structural variations on different length scales, while the time scales have to be accounted for due to alterations upon the interaction with living cells. A better understanding of cellular processes depending on the properties and dynamics of synthetic biomaterials supplies information about the material parameters, which are most important to grow viable and functional regenerative materials for clinical use and ex vivo tissue models.
Team
Projects
Publications
Titel/Autoren | Magazine | Jahre | |
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Fabrication of pH-Degradable Supramacromolecular Microgels with Tunable Size and Shape via Droplet-Based Microfluidics
S. H. Jung, S. Bulut, L. P. B. Busca Guerzoni, D. Günther, S. Braun, L. De Laporte and A. Pich
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Journal of Colloid and Interface Science | 2022 | |
Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture
D. Rommel, M. Mork, S. Vedaraman, C. Bastard, L. P. B. Guerzoni, Y. Kittel, R. Vinokur, N. Born, T. Haraszti and L. De Laporte
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Advanced Science | 2022 | |
Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment
S. Vedaraman, A. Perez-Tirado, T. Haraszti, J. Gerardo-Nava, A. Nishiguchi and L. De Laporte
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Advanced Healthcare Materials | 2021 | |
Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels
S. Vedaraman, D. Bernhagen, T. Haraszti, C. Licht, A. Castro Nava, A. Omidinia Anarkoli, P. Timmerman and L. De Laporte
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Biomaterials Science | 2021 | |
Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy
S. Babu, F. Albertino, A. Omidinia Anarkoli and L. De Laporte
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Advanced Healthcare Materials | 2021 | |
Is the Microgel Collapse a Two-Step Process? Exploiting Cononsolvency to Probe the Collapse Dynamics of Poly-N-isopropylacrylamide (pNIPAM)
K. Nothdurft, D. H. Müller, S. D. Mürtz, A. A. Meyer, L. P. B. Guerzoni, A. Jans, A. J. C. Kühne, L. De Laporte, T. Brands, A. Bardow and W. Richtering
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Journal of Physical Chemistry B | 2021 | |
Synergy of Advanced Experimental and Modeling Tools to Underpin the Synthesis of Static Step-Growth-Based Networks Involving Polymeric Precursor Building Blocks
L. De Keer, F. Cavalli, D. Estupiñán, A. J. D. Krüger, S. Rocha, P. H. M. Van Steenberge, M.-F. Reyniers, L. De Laporte, J. Hofkens, L. Barner and D. R. D’hooge
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Macromolecules | 2021 | |
Translating Therapeutic Microgels into Clinical Applications
Y. Kittel, A. J. C. Kühne and L. De Laporte
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Advanced Healthcare Materials | 2021 | |
Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids
M. Kruger, L. A. Oosterhoff, M. E. van Wolferen, S. A. Schiele, A. Walther, N. Geijsen, L. De Laporte, L. J. W. van der Laan, L. M. Kock, B. Spee
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Advanced Healthcare Materials | 2020 | |
Digitally Fabricated and Naturally Augmented In Vitro Tissues
D. F. Duarte Campos and L. De Laporte
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Advanced Healthcare Materials | 2020 | |
Granular Cellulose Nanofibril Hydrogel Scaffolds for 3D Cell Cultivation
D. B. Gehlen, N. Jürgens, A. Omidinia‐Anarkoli, T. Haraszti, J. George, A. Walther, H. Ye and L. De Laporte
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Macromolecular Rapid Communications | 2020 | |
Hierarchical fibrous guiding cues at different scales influence linear neurite extension
A. Omidinia-Anarkoli, J. W. Ephraim, R. Rimal and L. De Laporte
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Acta Biomaterialia | 2020 |