The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Prof. Dr. Ulrich Schwaneberg
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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What's My Substrate? Computational Function Assignment of Candida parapsilosis ADH5 by Genome Database Search, Virtual Screening, and QM/MM Calculations
G. V. Dhoke, Y. Ensari, M. D. Davari, A. J. Ruff, U. Schwaneberg and M. Bocola
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https://www.doi.org/10.1021/acs.jcim.6b00076 | Journal of Chemical Information and Modeling | 2016 | |
Validated High-Throughput Screening System for Directed Evolution of Nylon-Depolymerizing Enzymes
H. Puetz, C. Janknecht, F. Contreras, M. Vorobii, T. Kurkina and U. Schwaneberg
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https://doi.org/10.1021/acssuschemeng.3c01575 | ACS Sustainable Chemistry & Engineering | 2023 | |
Using Molecular Simulation to Guide Protein Engineering for Biocatalysis in Organic Solvents
H. Cui, M. Vedder, U. Schwaneberg and M. D. Davari
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https://doi.org/10.1007/978-1-0716-1826-4_10 | Enzyme Engineering | 2021 | |
Using a Bio-Economic Farm Model to Evaluate the Economic Potential and Pesticide Load Reduction of the Greenrelease Technology
T. Kuhn, N. Möhring, A. Töpel, F. Jakob, W. Britz, S. Bröring, A. Pich, U. Schwaneberg and M. Rennings
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https://doi.org/10.1016/j.agsy.2022.103454 | Agricultural Systems | 2022 | |
Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings
D. Söder, M. Garay-Sarmiento, K. Rahimi, F. Obstals, S. Dedisch, T. Haraszti, M. D. Davari, F. Jakob, C. Heß, U. Schwaneberg and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202100158 | Macromolecular Bioscience | 2021 | |
Unraveling the effects of amino acid substitutions enhancing lipase resistance to an ionic liquid: a molecular dynamics study
J. Zhao, V. J. Frauenkron-Machedjou, A. Fulton, L. L. Zhu, M. D. Davari, K. E. Jaeger, U. Schwaneberg and M. Bocola
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https://www.doi.org/10.1039/c7cp08470f | Physical Chemistry Chemical Physics | 2018 | |
Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
S. Brands, J. G. Sikkens, M. D. Davari, H. U. C. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff and U. Schwaneberg
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https://doi.org/10.1039/D0CC08226K | Chemical Communications | 2021 | |
Ultrahigh-throughput screening system for directed polymer binding peptide evolution
L. Apitius, K. Rubsam, C. Jakesch, F. Jakob and U. Schwaneberg
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https://www.doi.org/10.1002/bit.26990 | Biotechnol Bioeng | 2019 | |
Turning a Killing Mechanism into an Adhesion and Antifouling Advantage
S. Dedisch, F. Obstals, A. de los Santos Pereira, M. Bruns, F. Jakob, U. Schwaneberg and C. Rodriguez-Emmenegger
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https://www.doi.org/10.1002/admi.201900847 | Advanced Materials Interfaces | 2019 | |
Tunnel engineering for modulating the substrate preference in cytochrome P450BsβHI
S. Meng, R. An, Z. Li, U. Schwaneberg, Y. Ji, M. D. Davari, F. Wang, M. Wang, M. Qin, K. Nie and L. Liu
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https://doi.org/10.1186/s40643-021-00379-1 | Bioresources and Bioprocessing | 2021 | |
Tunable Enzymatic Activity and Enhanced Stability of Cellulase Immobilized in Biohybrid Nanogels
H. Peng, K. Rubsam, F. Jakob, U. Schwaneberg and A. Pich
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https://www.doi.org/10.1021/acs.biomac.6b01119 | Biomacromolecules | 2016 | |
Transformative Materials for Interfacial Drug Delivery
P. Desai, A. Dasgupta, A. M. Sofias, Q. Peña, R. Göstl, I. Slabu, U. Schwaneberg, T. Stiehl, W. Wagner, S. Jockenhövel, J. Stingl, R. Kramann, C. Trautwein, T. H. Brümmendorf, F. Kiessling, A. Herrmann and T. Lammers
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https://doi.org/10.1002/adhm.202301062 | Advanced Healthcare Materials | 2023 |