The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Prof. Dr. Ulrich Schwaneberg
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of beta-barrel hybrid catalyst for phenylacetylene polymerization
J. Kinzel, D. F. Sauer, M. Bocola, M. Arlt, T. M. Garakani, A. Thiel, K. Beckerle, T. Polen, J. Okuda and U. Schwaneberg
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https://www.doi.org/10.3762/bjoc.13.148 | Beilstein Journal of Organic Chemistry | 2017 | |
A 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3
A. Gartner, A. J. Ruff and U. Schwaneberg
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https://www.doi.org/10.1038/s41598-019-52077-w | Scientific Reports | 2019 | |
A bifunctional dermaseptin–thanatin dipeptide functionalizes the crop surface for sustainable pest management
P. Schwinges, S. Pariyar, F. Jakob, M. Rahimi, L. Apitius, M. Hunsche, L. Schmitt, G. Noga, C. Langenbach, U. Schwaneberg and U. Conrath
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https://www.doi.org/10.1039/C9GC00457B | Green Chemistry | 2019 | |
A colourimetric high-throughput screening system for directed evolution of prodigiosin ligase PigC
S. Brands, H. U. C. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff and U. Schwaneberg
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https://doi.org/10.1039/d0cc02181d | Chemical Communications | 2020 | |
A Comparative Reengineering Study of cpADH5 through Iterative and Simultaneous Multisite Saturation Mutagenesis
Y. Ensari, G. V. Dhoke, M. D. Davari, A. J. Ruff and U. Schwaneberg
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https://www.doi.org/10.1002/cbic.201800159 | Chembiochem | 2018 | |
A Competitive High-Throughput Screening Platform for Designing Polylactic Acid-Specific Binding Peptides
Y. Lu, K.-W. Hintzen, T. Kurkina, Y. Ji and U. Schwaneberg
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https://doi.org/10.1002/advs.202303195 | Advanced Science | 2023 | |
A Flow Cytometry-Based Ultrahigh-Throughput Screening Method for Directed Evolution of Oxidases
L. Feng, L. Gao, V. Besirlioglu, K. Essani, M. Wittwer, T. Kurkina, Y. Ji and U. Schwaneberg
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https://doi.org/10.1002/anie.202214999 | Angewandte Chemie International Edition | 2023 | |
A hydroquinone-specific screening system for directed P450 evolution
A. M. Weingartner, D. F. Sauer, G. V. Dhoke, M. D. Davari, A. J. Ruff and U. Schwaneberg
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https://www.doi.org/10.1007/s00253-018-9328-3 | Applied Microbiology and Biotechnology | 2018 | |
A loop engineering strategy improves laccase lcc2 activity in ionic liquid and aqueous solution
A. M. Wallraf, H. F. Liu, L. L. Zhu, G. Khalfallah, C. Simons, H. Alibiglou, M. D. Davari and U. Schwaneberg
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https://www.doi.org/10.1039/c7gc03776g | Green Chemistry | 2018 | |
A peptide-based coating toolbox to enable click chemistry on polymers, metals, and silicon through sortagging
M. Nöth, Z. Zou, I. El-Awaad, L. C. de Lencastre Novaes, G. Dilarri, M. D. Davari, H. Ferreira, F. Jakob and U. Schwaneberg
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https://doi.org/10.1002/bit.27666 | Bioengineering | 2021 | |
A Photoclick-Based High-Throughput Screening for the Directed Evolution of Decarboxylase OleT
U. Markel, P. Lanvers, D. F. Sauer, M. Wittwer, G. V. Dhoke, M. D. Davari, J. Schiffels and U. Schwaneberg
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https://doi.org/10.1002/chem.202003637 | Chemistry – A European Journal | 2020 | |
A Phylogeny-Based Directed Evolution Approach to Boost the Synthetic Applications of Glycosyltransferases
P. Zhang, Y. Ji, S. Meng, Z. Li, D. Hirtz, L. Elling and U. Schwaneberg
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https://doi.org/10.1039/D3GC01259J | Green Chemistry | 2023 |