The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Prof. Dr. Ulrich Schwaneberg
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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A whole cell biocatalyst for double oxidation of cyclooctane
C. A. Muller, A. M. Weingartner, A. Dennig, A. J. Ruff, H. Groger and U. Schwaneberg
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https://www.doi.org/10.1007/s10295-016-1844-5 | Journal of Industrial Microbiology & Biotechnology | 2016 | |
CaLB Catalyzed Conversion of epsilon-Caprolactone in Aqueous Medium. Part 1: Immobilization of CaLB to Microgels
S. Engel, H. Hock, M. Bocola, H. Keul, U. Schwaneberg and M. Moller
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https://www.doi.org/10.3390/polym8100372 | Polymers | 2016 | |
Grafting PNIPAAm from beta-barrel shaped transmembrane nanopores
H. Charan, J. Kinzel, U. Glebe, D. Anand, T. M. Garakani, L. L. Zhu, M. Bocola, U. Schwaneberg and A. Boker
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https://www.doi.org/10.1016/j.biomaterials.2016.08.033 | Biomaterials | 2016 | |
In vitro flow cytometry-based screening platform for cellulase engineering
G. Korfer, C. Pitzler, L. Vojcic, R. Martinez and U. Schwaneberg
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https://www.doi.org/10.1038/srep26128 | Sci Rep | 2016 | |
Photophysics of the LOV-Based Fluorescent Protein Variant iLOV-Q489K Determined by Simulation and Experiment
M. D. Davari, B. Kopka, M. Wingen, M. Bocola, T. Drepper, K. E. Jaeger, U. Schwaneberg and U. Krauss
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https://www.doi.org/10.1021/acs.jpcb.6b01512 | Journal of Physical Chemistry B | 2016 | |
Reactive Copolymers Based on N-Vinyl Lactams with Pyridyl Disulfide Side Groups via RAFT Polymerization and Postmodification via Thiol-Disulfide Exchange Reaction
H. Peng, K. Rubsam, X. B. Huang, F. Jakob, M. Karperien, U. Schwaneberg and A. Pich
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https://www.doi.org/10.1021/acs.macromol.6b01210 | Macromolecules | 2016 | |
Reversible Deactivation of Enzymes by Redox-Responsive Nanogel Carriers
H. Peng, K. Rubsam, F. Jakob, P. Pazdzior, U. Schwaneberg and A. Pich
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https://www.doi.org/10.1002/marc.201600476 | Macromolecular Rapid Communications | 2016 | |
Screening through the PLICable promoter toolbox enhances protein production in Escherichia coli
J. H. Yang, A. J. Ruff, S. N. Hamer, F. Cheng and U. Schwaneberg
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https://www.doi.org/10.1002/biot.201600270 | Biotechnology Journal | 2016 | |
Tunable Enzymatic Activity and Enhanced Stability of Cellulase Immobilized in Biohybrid Nanogels
H. Peng, K. Rubsam, F. Jakob, U. Schwaneberg and A. Pich
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https://www.doi.org/10.1021/acs.biomac.6b01119 | Biomacromolecules | 2016 | |
What's My Substrate? Computational Function Assignment of Candida parapsilosis ADH5 by Genome Database Search, Virtual Screening, and QM/MM Calculations
G. V. Dhoke, Y. Ensari, M. D. Davari, A. J. Ruff, U. Schwaneberg and M. Bocola
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https://www.doi.org/10.1021/acs.jcim.6b00076 | Journal of Chemical Information and Modeling | 2016 | |
2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of beta-barrel hybrid catalyst for phenylacetylene polymerization
J. Kinzel, D. F. Sauer, M. Bocola, M. Arlt, T. M. Garakani, A. Thiel, K. Beckerle, T. Polen, J. Okuda and U. Schwaneberg
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https://www.doi.org/10.3762/bjoc.13.148 | Beilstein Journal of Organic Chemistry | 2017 | |
An Enzymatic Route to alpha-Tocopherol Synthons: Aromatic Hydroxylation of Pseudocumene and Mesitylene with P450 BM3
A. Dennig, A. M. Weingartner, T. Kardashliev, C. A. Muller, E. Tassano, M. Schurmann, A. J. Ruff and U. Schwaneberg
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https://www.doi.org/10.1002/chem.201703647 | Chemistry-a European Journal | 2017 |