The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Prof. Dr. Ulrich Schwaneberg
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Nano-thin walled micro-compartments from transmembrane protein-polymer conjugates
H. Charan, U. Glebe, D. Anand, J. Kinzel, L. L. Zhu, M. Bocola, T. M. Garakani, U. Schwaneberg and A. Boker
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https://www.doi.org/10.1039/c6sm02520j | Soft Matter | 2017 | |
Commentary: Polymer Binding Modules Accelerate Enzymatic Degradation of Poly(Ethylene Terephthalate)
Y. Lu, R. Han, U. Schwaneberg and Y. Ji
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https://doi.org/10.13345/j.cjb.221033 | Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology | 2023 | |
Electron transfer pathways in a light, oxygen, voltage (LOV) protein devoid of the photoactive cysteine
B. Kopka, K. Magerl, A. Savitsky, M. D. Davari, K. Rollen, M. Bocola, B. Dick, U. Schwaneberg, K. E. Jaeger and U. Krauss
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https://www.doi.org/10.1038/s41598-017-13420-1 | Scientific Reports | 2017 | |
A 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3
A. Gartner, A. J. Ruff and U. Schwaneberg
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https://www.doi.org/10.1038/s41598-019-52077-w | Scientific Reports | 2019 | |
Plastibodies for Multiplexed Detection and Sorting of Microplastic Particles in High-Throughput
W. Bauten, M. Nöth, T. Kurkina, F. Contreras, Y. Ji, C. Desmet, M.-Á. Serra, D. Gilliland and U. Schwaneberg
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https://doi.org/10.1016/j.scitotenv.2022.160450 | Science of The Total Environment | 2022 | |
In vitro flow cytometry-based screening platform for cellulase engineering
G. Korfer, C. Pitzler, L. Vojcic, R. Martinez and U. Schwaneberg
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https://www.doi.org/10.1038/srep26128 | Sci Rep | 2016 | |
Protein Engineering by Efficient Sequence Space Exploration through Combination of Directed Evolution and Computational Design Methodologies
S. Pramanik, F. Contreras, M. D. Davari and U. Schwaneberg
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https://doi.org/10.1002/9783527815128.ch7 | Protein Engineering: Tools and Applications | 2021 | |
Directed evolution of P450cin for mediated electron transfer
K. D. Belsare, T. Horn, A. J. Ruff, R. Martinez, A. Magnusson, D. Holtmann, J. Schrader and U. Schwaneberg
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https://www.doi.org/10.1093/protein/gzw072 | Protein Engineering Design & Selection | 2017 | |
Sortase-Mediated Ligation of Purely Artificial Building Blocks
X. L. Dai, D. M. Mate, U. Glebe, T. M. Garakani, A. Korner, U. Schwaneberg and A. Boker
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https://www.doi.org/10.3390/polym10020151 | Polymers | 2018 | |
KnowVolution of the Polymer-Binding Peptide LCI for Improved Polypropylene Binding
K. Rubsam, M. D. Davari, F. Jakob and U. Schwaneberg
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https://www.doi.org/10.3390/polym10040423 | Polymers | 2018 | |
Comparison of Candida antarctica Lipase B Variants for Conversion of epsilon-Caprolactone in Aqueous MediumPart 2
H. Hock, S. Engel, S. Weingarten, H. Keul, U. Schwaneberg, M. Moller and M. Bocola
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https://www.doi.org/10.3390/polym10050524 | Polymers | 2018 | |
CaLB Catalyzed Conversion of epsilon-Caprolactone in Aqueous Medium. Part 1: Immobilization of CaLB to Microgels
S. Engel, H. Hock, M. Bocola, H. Keul, U. Schwaneberg and M. Moller
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https://www.doi.org/10.3390/polym8100372 | Polymers | 2016 |