The research of our group focuses on synthetic chemistry and molecular biology. Chemists, biologists and physicists are dedicated to the task of inventing new molecular technologies to create new (bio)molecular and biohybrid structures by combining chemical and biological processes. Our group has pioneered the development of two classes of materials: nucleic acid polymer conjugates and supercharged polypeptides. Inspired by nature, these materials are designed to form well-defined molecular architectures that span multiple length scales from nanometer to macroscopic structures. These structures are key for the realization of complex functions in technological, medical and life science applications.
Sonopharmacology: Our group was the first to transfer concepts from polymer mechanochemistry to the life sciences. Ultrasound and the resulting shear forces in aqueous environment act as external trigger to activate different classes of drug molecules realizing a novel concept for precision targeting medicines.
D. Yiliz, R. Göstl & A. Herrmann: Chem. Sci. 2022, 13: 13708-13719
S. Huo et al.: Nat. Chem. 2021, 13: 131-139
Sonogenetics: Besides switching on active pharmaceutical ingredients by ultrasound, we exploit this trigger to manipulate the activity of proteins and genes. Enzymes and nucleic acids are designed to respond to low intensity biocompatible ultrasound to remotely orchestrate biological systems deep inside the body in the future.
J. Hahmann et al.: Angew. Chem. Int. Ed. 2024, e202317112
P. Zhao et al.: Angew. Chem. Int. Ed. 2021, 60(26): 14707-14714
Ultrastrong Bioadhesives: We design molecular glues de novo by exploiting recombinant protein expression and genetic engineering. Supercharged polypeptides were complexed with surfactants to form coacervate-based adhesives with outstanding features such as temperature switchability, hemostatic and wound healing promoting properties.
Y. Zhou et al.: Adv. Mater. 2023, 35(16): 2210052
C. Ma et al.: Nat. Commun. 2021, 12: 3613
Prof. Dr. Andreas Herrmann
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Ultrasound-Controlled Drug Release and Drug Activation for Cancer Therapy
L. Tu, Z. Liao, Z. Luo, Y.-L. Wu, A. Herrmann and S. Huo
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https://doi.org/10.1002/EXP.20210023 | Exploration | 2021 | |
Ultrasound Responsive Microcapsules for Antibacterial Nanodrug Delivery
J. Fan, M. Xuan, P. Zhao, M. Loznik, J. Chen, F. Kiessling, L. Zhen, A. Herrmann
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https://doi.org/10.1007/s12274-022-4919-9 | Nano Research | 2022 | |
Ultra-strong bio-glue from genetically engineered polypeptides
Chao Ma, Jing Sun, Bo Li, Yang Feng, Yao Sun, Li Xiang, Baiheng Wu, Lingling Xiao, Baimei Liu, Vladislav S. Petrovskii, Bin Liu, Jinrui Zhang, Zili Wang, Hongyan Li, Lei Zhang, Jingjing Li, Fan Wang, Robert Gӧstl, Igor I. Potemkin, Dong Chen, Hongbo Zeng, Hongjie Zhang, Kai Liu & Andreas Herrmann
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https://doi.org/10.1038/s41467-021-23117-9 | Nature Communications | 2021 | |
Transformative Materials to Create 3D Functional Human Tissue Models in Vitro in a Reproducible Manner
J. L. Gerardo-Nava, J. Jansen, D. Günther, L. Klasen, A. L. Thiebes, B. Niessing, C. Bergerbit, A. A. Meyer, J. Linkhorst, M. Barth, P. Akhyari, J. Stingl, S. Nagel, T. Stiehl, A. Lampert, R. Leube, M. Wessling, F. Santoro, S. Ingebrandt, S. Jockenhoevel, A. Herrmann, H. Fischer, W. Wagner, R. H. Schmitt, F. Kiessling, R. Kramann and L. De Laporte
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https://doi.org/10.1002/adhm.202301030 | Advanced Healthcare Materials | 2023 | |
Transformative Materials for Interfacial Drug Delivery
P. Desai, A. Dasgupta, A. M. Sofias, Q. Peña, R. Göstl, I. Slabu, U. Schwaneberg, T. Stiehl, W. Wagner, S. Jockenhövel, J. Stingl, R. Kramann, C. Trautwein, T. H. Brümmendorf, F. Kiessling, A. Herrmann and T. Lammers
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https://doi.org/10.1002/adhm.202301062 | Advanced Healthcare Materials | 2023 | |
Toward Drug Release Using Polymer Mechanochemical Disulfide Scission
Z. Shi, J. Wu, Q. Song, R. Göstl and A. Herrmann
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https://doi.org/10.1021/jacs.0c07077 | Journal of the American Chemical Society | 2020 | |
The Mechanochemical Synthesis and Activation of Carbon-Rich π-Conjugated Materials
M. Xuan, C. Schumacher, C. Bolm, R. Göstl and A. Herrmann
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https://doi.org/10.1002/advs.202105497 | Advanced Science | 2022 | |
The Mechanochemical Release of Naphthalimide Fluorophores from Β-Carbonate and Β-Carbamate Disulfide-Centered Polymers
Z. Shi, Q. Song, R. Göstl and A. Herrmann
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https://doi.org/10.31635/ccschem.021.202101147 | CCS Chemistry | 2021 | |
Supercharged Proteins and Polypeptides
C. Ma, A. Malessa, A. J. Boersma, K. Liu and A. Herrmann
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https://doi.org/10.1002/adma.201905309 | Advanced Materials | 2020 | |
Sonopharmacology: Controlling Pharmacotherapy and Diagnosis by Ultrasound-Induced Polymer Mechanochemistry
D. Yildiz, R. Göstl and A. Herrmann
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http://dx.doi.org/10.1039/D2SC05196F | Chemical Science | 2022 | |
Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound
J. Hahmann, A. Ishaqat, T. Lammers and A. Herrmann
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https://doi.org/10.1002/anie.202317112 | Angewandte Chemie International Edition | 2024 | |
Soft Matter DNA Nanoparticles Hybridized with CpG Motifs and Peptide Nucleic Acids Enable Immunological Treatment of Cancer
J. O. Jin, H. Kim, Y. Huh, A. Herrmann, M. Kwak
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https://www.ncbi.nlm.nih.gov/pubmed/31639342 | J Control Release | 2019 |