The research of our group focuses on synthetic chemistry and molecular biology. Chemists, biologists and physicists are dedicated to the task of inventing new molecular technologies to create new (bio)molecular and biohybrid structures by combining chemical and biological processes. Our group has pioneered the development of two classes of materials: nucleic acid polymer conjugates and supercharged polypeptides. Inspired by nature, these materials are designed to form well-defined molecular architectures that span multiple length scales from nanometer to macroscopic structures. These structures are key for the realization of complex functions in technological, medical and life science applications.
Sonopharmacology: Our group was the first to transfer concepts from polymer mechanochemistry to the life sciences. Ultrasound and the resulting shear forces in aqueous environment act as external trigger to activate different classes of drug molecules realizing a novel concept for precision targeting medicines.
D. Yiliz, R. Göstl & A. Herrmann: Chem. Sci. 2022, 13: 13708-13719
S. Huo et al.: Nat. Chem. 2021, 13: 131-139
Sonogenetics: Besides switching on active pharmaceutical ingredients by ultrasound, we exploit this trigger to manipulate the activity of proteins and genes. Enzymes and nucleic acids are designed to respond to low intensity biocompatible ultrasound to remotely orchestrate biological systems deep inside the body in the future.
J. Hahmann et al.: Angew. Chem. Int. Ed. 2024, e202317112
P. Zhao et al.: Angew. Chem. Int. Ed. 2021, 60(26): 14707-14714
Ultrastrong Bioadhesives: We design molecular glues de novo by exploiting recombinant protein expression and genetic engineering. Supercharged polypeptides were complexed with surfactants to form coacervate-based adhesives with outstanding features such as temperature switchability, hemostatic and wound healing promoting properties.
Y. Zhou et al.: Adv. Mater. 2023, 35(16): 2210052
C. Ma et al.: Nat. Commun. 2021, 12: 3613
Prof. Dr. Andreas Herrmann
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Protein Orientation Defines Rectification of Electronic Current Via Solid-State Junction of Entire Photosystem-1 Complex
J. A. Fereiro, T. Bendikov, A. Herrmann, I. Pecht, M. Sheves and D. Cahen
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https://doi.org/10.1021/acs.jpclett.2c03700 | The Journal of Physical Chemistry Letters | 2023 | |
Biochemical and Structural Insight into the Chemical Resistance and Cofactor Specificity of the Formate Dehydrogenase from Starkeya Novella
M. Partipilo, J. J. Whittaker, N. Pontillo, J. Coenradij, A. Herrmann, A. Guskov and D. J. Slotboom
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https://doi.org/10.1111/febs.16871 | The FEBS Journal | 2023 | |
Nematic DNA Thermotropic Liquid Crystals with Photoresponsive Mechanical Properties
L. Zhang, S. Maity, K. Liu, Q. Liu, R. Göstl, G. Portale, W. H. Roos and A. Herrmann
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https://www.doi.org/10.1002/smll.201701207 | Small | 2017 | |
Gold-DNA nanosunflowers for efficient gene silencing with controllable transformation
S. Huo, N. Gong, Y. Jiang, F. Chen, H. Guo, Y. Gan, Z. Wang, A. Herrmann, X.-J. Liang
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https://advances.sciencemag.org/content/5/10/eaaw6264.full | Science Advances | 2019 | |
De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane
C. Ma, J. Dong, M. Viviani, I. Tulini, N. Pontillo, S. Maity, Y. Zhou, W. H. Roos, K. Liu, A. Herrmann and G. Portale
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https://doi.org/10.1126/sciadv.abc0810 | Science Advances | 2020 | |
Multiplexed Sensing of Biomolecules with Optically Detected Magnetic Resonance of Nitrogen-Vacancy Centers in Diamond
M. Kayci, J. Fan, O. Bakirman and A. Herrmann
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https://doi.org/10.1073/pnas.2112664118 | Proceedings of the National Academy of Sciences | 2021 | |
Animal Fiber Identification under the Open Set Condition
O. Rippel, S. Gülçelik, K. Rahimi, J. Kurniadi, A. Herrmann, D. Merhof
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https://doi.org/10.5220/0010769800003124 | Proceedings of the 17th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications | 2022 | |
ColiCoords: A Python package for the analysis of bacterial fluorescence microscopy data
J. H. Smit, Y. Li, E. M. Warszawik, A. Herrmann and T. Cordes
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https://www.doi.org/10.1371/journal.pone.0217524 | PLoS One | 2019 | |
On the impact of competing intra- and intermolecular triplet-state quenching on photobleaching and photoswitching kinetics of organic fluorophores
J. H. v. d. V. Smit, J. H. M.; Huang, J. Y.; Trauschke, V.; Henrikus, S. S.; Chen, S.; Eleftheriadis, N.; Warszawik, E. M.; Herrmann, A.; Cordes, T.
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https://www.doi.org/10.1039/c8cp05063e | Physical Chemistry Chemical Physics | 2019 | |
Lipid-DNA Nanoparticles as Drug-Delivery Vehicles for the Treatment of Retinal Diseases
S. Schnichels, D. Simmang, M. Löscher, A. Herrmann, J. W. de Vries, M. S. Spitzer and J. Hurst
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https://doi.org/10.3390/pharmaceutics15020532 | Pharmaceutics | 2023 | |
Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B
A. A. Bastian, A. Gruszka, P. Jung and A. Herrmann
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https://doi.org/10.1039/D0OB02104K | Organic & Biomolecular Chemistry | 2020 | |
Dissipative adaptation in driven self-assembly leading to self-dividing fibrils
E. te Brinke, J. Groen, A. Herrmann, H. A. Heus, G. Rivas, E. Spruijt and W. T. S. Huck
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https://www.doi.org/10.1038/s41565-018-0192-1 | Nature Nanotechnology | 2018 |