The research of our group focuses on synthetic chemistry and molecular biology. Chemists, biologists and physicists are dedicated to the task of inventing new molecular technologies to create new (bio)molecular and biohybrid structures by combining chemical and biological processes. Our group has pioneered the development of two classes of materials: nucleic acid polymer conjugates and supercharged polypeptides. Inspired by nature, these materials are designed to form well-defined molecular architectures that span multiple length scales from nanometer to macroscopic structures. These structures are key for the realization of complex functions in technological, medical and life science applications.
Sonopharmacology: Our group was the first to transfer concepts from polymer mechanochemistry to the life sciences. Ultrasound and the resulting shear forces in aqueous environment act as external trigger to activate different classes of drug molecules realizing a novel concept for precision targeting medicines.
D. Yiliz, R. Göstl & A. Herrmann: Chem. Sci. 2022, 13: 13708-13719
S. Huo et al.: Nat. Chem. 2021, 13: 131-139
Sonogenetics: Besides switching on active pharmaceutical ingredients by ultrasound, we exploit this trigger to manipulate the activity of proteins and genes. Enzymes and nucleic acids are designed to respond to low intensity biocompatible ultrasound to remotely orchestrate biological systems deep inside the body in the future.
J. Hahmann et al.: Angew. Chem. Int. Ed. 2024, e202317112
P. Zhao et al.: Angew. Chem. Int. Ed. 2021, 60(26): 14707-14714
Ultrastrong Bioadhesives: We design molecular glues de novo by exploiting recombinant protein expression and genetic engineering. Supercharged polypeptides were complexed with surfactants to form coacervate-based adhesives with outstanding features such as temperature switchability, hemostatic and wound healing promoting properties.
Y. Zhou et al.: Adv. Mater. 2023, 35(16): 2210052
C. Ma et al.: Nat. Commun. 2021, 12: 3613
Prof. Dr. Andreas Herrmann
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Liquefaction of Biopolymers: Solvent-free Liquids and Liquid Crystals from Nucleic Acids and Proteins
K. Liu, C. Ma, R. Göstl, L. Zhang and A. Herrmann
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https://www.doi.org/10.1021/acs.accounts.7b00030 | Accounts of Chemical Research | 2017 | |
Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles
S. Schnichels, J. Hurst, J. W. de Vries, S. Ullah, K. Frößl, A. Gruszka, M. Löscher, K.-U. Bartz-Schmidt, M. S. Spitzer and A. Herrmann
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https://doi.org/10.1021/acsami.0c18626 | ACS Applied Materials & Interfaces | 2021 | |
Next Generation Salivary Lubrication Enhancer Derived from Recombinant Supercharged Polypeptides for Xerostomia
H. Wan, C. Ma, J. Vinke, A. Vissink, A. Herrmann and P. K. Sharma
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https://doi.org/10.1021/acsami.0c06159 | Acs Applied Materials & Interfaces | 2020 | |
Self-Regenerating Soft Biophotovoltaic Devices
X. K. Qiu, O. C. Ocampo, H. W. de Vries, M. van Putten, M. Loznik, A. Herrmann and R. C. Chiechi
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https://www.doi.org/10.1021/acsami.8b11115 | Acs Applied Materials & Interfaces | 2018 | |
Activation of Antibiotic-Grafted Polymer Brushes by Ultrasound
M. Zou, P. Zhao, S. Huo, R. Göstl and A. Herrmann
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https://doi.org/10.1021/acsmacrolett.1c00645 | ACS Macro Letters | 2021 | |
Force Ahead: Emerging Applications and Opportunities of Polymer Mechanochemistry
H.-A. Klok, A. Herrmann and R. Göstl
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https://doi.org/10.1021/acspolymersau.2c00029 | ACS Polymers Au | 2022 | |
An Optimized Sensor Array Identifies All Natural Amino Acids
B. H. Wang, J. S. Han, N. M. Bojanowski, M. Bender, C. Ma, K. Seehafer, A. Herrmann and U. H. F. Bunz
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https://www.doi.org/10.1021/acssensors.8b00371 | Acs Sensors | 2018 | |
Fast, Efficient, and Targeted Liposome Delivery Mediated by DNA Hybridization
H. Li, Q. Liu, B. J. Crielaard, J. W. de Vries, M. Loznik, Z. Meng, X. Yang, R. Göstl and A. Herrmann
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https://www.doi.org/10.1002/adhm.201900389 | Adv Healthc Mater | 2019 | |
Transformative Materials for Interfacial Drug Delivery
P. Desai, A. Dasgupta, A. M. Sofias, Q. Peña, R. Göstl, I. Slabu, U. Schwaneberg, T. Stiehl, W. Wagner, S. Jockenhövel, J. Stingl, R. Kramann, C. Trautwein, T. H. Brümmendorf, F. Kiessling, A. Herrmann and T. Lammers
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https://doi.org/10.1002/adhm.202301062 | Advanced Healthcare Materials | 2023 | |
Transformative Materials to Create 3D Functional Human Tissue Models in Vitro in a Reproducible Manner
J. L. Gerardo-Nava, J. Jansen, D. Günther, L. Klasen, A. L. Thiebes, B. Niessing, C. Bergerbit, A. A. Meyer, J. Linkhorst, M. Barth, P. Akhyari, J. Stingl, S. Nagel, T. Stiehl, A. Lampert, R. Leube, M. Wessling, F. Santoro, S. Ingebrandt, S. Jockenhoevel, A. Herrmann, H. Fischer, W. Wagner, R. H. Schmitt, F. Kiessling, R. Kramann and L. De Laporte
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https://doi.org/10.1002/adhm.202301030 | Advanced Healthcare Materials | 2023 | |
Engineered Near‐Infrared Fluorescent Protein Assemblies for Robust Bioimaging and Therapeutic Applications
J. J. Li, B. Li, J. Sun, C. Ma, S. K. Wan, Y. X. Li, R. Göstl, A. Herrmann, K. Liu and H. J. Zhang
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https://doi.org/10.1002/adma.202000964 | Advanced Materials | 2020 | |
Fabrication and Mechanical Properties of Engineered Protein-Based Adhesives and Fibers
J. Sun, J. J. Su, C. Ma, R. Gostl, A. Herrmann, K. Liu and H. J. Zhang
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https://www.doi.org/10.1002/adma.201906360 | Advanced Materials | 2019 |