Time-programmed release from liposome loaded microgels

In cooperation with RG Pich.

Project description

This research project is targeted at master students who wish to complete their final thesis on a cross-disciplinary and collaborative topic. The goal of this project is to synthesize the next generation of biocompatible, step-wise drug-release systems. For this purpose, biodegradable microgels are loaded with lipid-based capsules (liposomes) that can release their contents in a programmed and time-controlled fashion step-by-step. In contrast to current state-of-the-art release systems, the liposome loaded microgels facilitate the controlled and cascaded release of multiple components with high temporal precision. Lastly, the microgels dissolve completely through programmed degradation. The project offers insights into the microfluidic synthesis of bio-based microgels, the self-assembly and formulation of complex liposomes and various spectroscopy and microscopy techniques.

Your tasks and responsibilities

During this research project you will synthesize microgel particles of homogeneous size and various architectures using a microfluidic polymerization technique. We use bio-based and bio-degradable polymers for that purpose. The microgels are loaded with liposomes of different formulations. You will prepare different types of responsive liposomes and study their stability and release profiles. Your task is to systematically tune the release profiles and cascaded reactions to program the responses in time. Finally, you will integrate the liposomes into the microgel particles and study the hierarchical assemblies on a systems level. You will carry out experiments responsibly following good laboratory practices and document your results in an electronic lab journal.

This is what we offer

• Opportunity to write your master thesis (background in chemistry beneficial) in a collaborative team of two DWI research groups
• Working at the interface of polymer and systems chemistry towards active materials
• Learning and improving your synthetic and analytical skills in state-of-the-art soft material science including a diverse set of techniques (e.g. microfluidics, confocal laser scanning microscopy, synthesis of microgels and the formulation of complex liposomes)
• Close supervision and guidance throughout your thesis
• Interdisciplinary, international and inclusive work environment in an enthusiastic team

We are happy to discuss the project further and to get to know you in person!