Prof. Dr. César Rodriguez-Emmenegger
The research program of the Rodriguez-Emmenegger group focuses in the development of synthetic and biohybrid adaptive interfaces able to interact with the environment drawing inspiration in the way living systems interact and communicate. The group's overarching goal is to understand how to balance the overall repellency with specific multivalent and cooperative attractive interactions to develop superselectivity at interfaces and to translate this to the medical field. Toward this aim synthetic polymer and supramolecular chemistry, physical chemistry, biophysics, and engineering converge in a highly interdisciplinary team. In particular the Emmenegger group is interested in synthesis of macromolecules with precise chemical composition, architecture and topology. These macromolecules are used to study and develop antifouling, antimicrobial surfaces, coatings that interact with blood and modulate uncontrolled coagulation, as well as active synthetic cells.
César Rodriguez-Emmenegger's publications via ORCID
César Rodriguez-Emmenegger's publications via google scholar
Resume
César was born in Salto, in the north of Uruguay. After studying Chemical Engineering (2001—2006) in the Universidad de la Republica he was awarded a research UNESCO-IUPAC internship (2006-2007) in the Institute of Macromolecular Chemistry in Prague where he got hooked in the topic of polymers and biointerfaces. There he pursued his Ph.D. in Biophysics, Chemical and Macromolecular Physics under the supervision of Dr. E. Brynda and Prof. A. Bologna-Alles (2007—2012) working on optical biosensors and antifouling surfaces. Following a postdoctoral research at the group of Prof. C. Barner-Kowollik (Alexander von Humboldt postdoctoral fellowship, 2012-2013), and research stays in Melville Laboratory in Cambridge (Prof. W.T.S. Huck, 2009), University of Pennsylvania (Prof. V. Percec, 2013, 2015) and Pasteur Institute in Lille (Prof. Lafont, 2015), César returned to Prague to start his independent group supported by a Junior Grant from GACR. In January 2016, his group joined DWI and expanded the research to adaptive interfaces and synthetic cells.
Selected professional functions, honors and awards
- 2020 Innovation Sprint RWTH
- 2015 Polymer Chemistry Emerging Investigators 2015 | Royal Society of Chemistry, UK
- 2014 Japan Society for the Promotin of Science, Postdoctoral Fellowship for North Americam and European Researches (ID No. PE14051, rejected for personal reasons)
- 2012 - 2013 Alexander von Humboldt Postdoctoral Research Fellow | Karlsruhe Institute of Technology, Karlsruhe, Germany
- 2006-2007 UNESCO-IUPAC Postgraduate Course in Polymer Science | Institute of Macromolecular Chemistry, the Czech Academy of Sciences, Prague, Czechia
- 2001 Bronze Medal, 33rd International Chemistry Olympiad | Mumbai, India
- 2000 Bronze Medal, 6th Iberoamerican Chemistry Olympiad | Caracas, Venezuela
Publications
| Titel/Autoren | DOI-LINK | Magazine | Jahre | |
|---|---|---|---|---|
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Enhanced Concanavalin A Binding to Preorganized Mannose Nanoarrays in Glycodendrimersomes Revealed Multivalent Interactions
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https://doi.org/10.1002/anie.202100400 | Angewandte Chemie International Edition | 2021 | |
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Improving Hemocompatibility: How Can Smart Surfaces Direct Blood To Fight against Thrombi
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https://doi.org/10.1021/acsami.1c01079 | ACS Applied Materials & Interfaces | 2021 | |
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Kill&Repel Coatings: The Marriage of Antifouling and Bactericidal Properties to Mitigate and Treat Wound Infections
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https://doi.org/10.1002/adfm.202106656 | Advanced Functional Materials | 2021 | |
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Oriented immobilization of Pep19-2.5 on antifouling brushes suppresses the development of Staphylococcus aureus biofilms
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https://doi.org/10.1016/j.porgcoat.2021.106609 | Progress in Organic Coatings | 2021 | |
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Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings
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https://doi.org/10.1002/mabi.202100158 | Macromolecular Bioscience | 2021 | |
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Controlled Surface Adhesion of Macrophages via Patterned Antifouling Polymer Brushes
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https://doi.org/10.1002/anbr.202000029 | Advanced NanoBiomed Research | 2020 | |
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Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms
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https://doi.org/10.1021/acsnano.0c02912 | ACS Nano | 2020 | |
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Efficacy of A Poly(MeOEGMA) Brush on the Prevention of Escherichia coli Biofilm Formation and Susceptibility
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https://doi.org/10.3390/antibiotics9050216 | Antibiotics | 2020 | |
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Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers
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https://doi.org/10.1073/pnas.2003938117 | Proceedings of the National Academy of Sciences of the United States of America | 2020 | |
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Surface plasmon resonance-based aptasensor for direct monitoring of thrombin in a minimally processed human blood
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https://doi.org/10.1016/j.snb.2020.128380 | Sensors and Actuators B-Chemical | 2020 | |
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The potential advantages of using a poly(HPMA) brush in urinary catheters: effects on biofilm cells and architecture
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https://doi.org/10.1016/j.colsurfb.2020.110976 | Colloids and Surfaces B: Biointerface | 2020 | |
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Unraveling topology-induced shape transformations in dendrimersomes
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https://doi.org/10.1039/D0SM01097A | Soft Matter | 2020 |
