EVPRO - Development of Extracellular Vesicles loaded hydrogel Coatings

with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Stem cell technology to promote endoprosthesis osseointegration

Revision endoprosthesis is often complicated by severe inflammatory post-surgical reactions in the endoprosthesis area, leading to long-term immobility and, in severe cases, implant rejection. The EU-funded EVPRO project will work on integrating multidisciplinary technologies to promote successful osseointegration of endoprostheses in osteoarticular tissue regeneration. The project will employ human mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which suppress inflammatory reactions and display pro-regenerative properties in osteogenic applications. The MSC-EVs will be delivered directly to the site of inflammation and affix to the implant surface, where they will exert their anti-inflammatory and regenerative effects in response to the local inflammation. Researchers aim to achieve this by integrating the MSC-EVs in biodegradable hydrogel absorbed into the micropores of a conventional titanium endoprosthesis.

Further information

Contact
Independent Group Leader

Dr. César Rodriguez-Emmenegger

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+49 241 80-23362
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A1.18
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PhD student

Lena Witzdam, M.Sc.

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+49 241 80-23367
Room
A 1.23a
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PhD student

Manuela Rosario Garay Sarmiento, M.Sc.

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+49 241 80-23367
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A 1.23b
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PhD student

Anna Maria Wagner, M.Sc.

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+49 241 80-23158
Room
B1.56
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