In vitro interactions between Schwann cells and Astrocytes with the 3D Anisogel System

As part of a multinational and multidisciplinary team, called “Mend the Gap”, the RG De Laporte aims to investigate the use of biomaterials for treating spinal cord injury (SCI) by injecting an anisotropic, soft gel, called Anisogel, into the site of the injury to serve as a bridge for growing nerve fibers. We will continue to design and optimize the Anisogel, bringing it closer to successful application in larger, more realistic models of SCI, with the support of our partners at the University of British Columbia (Vancouver, Canada). Furthermore, the project aims to collaborate with world leaders in the development and delivery of drug-based treatments to realize an integrated approach that leverages the latest and most important research findings.

Project Description

As part of the Mend the Gap project, you will study the infiltration of Neurons, Schwann Cells (SC), and Astrocytes (AC) into a synthetic 3D Hydrogel with and without anisometric cues to induce alignment. The findings of your thesis will directly benefit and influence the ongoing in vivo studies using Anisogel for spinal cord injury regeneration. Understanding, facilitating, and enhancing cell infiltration of both neurons and their supporting cells present in the spinal cord after injury is vital for the successful establishment of any therapeutic approach. In this regard, you will investigate single or co-cultures of SC and AC with different versions of the Anisogel used in these in vivo studies to find the most suitable version for cell infiltration.

We are looking for a motivated and enthusiastic student to join our RG De Laporte. You should be enrolled in the master’s program in biotechnology, biology, chemistry, or a related field, with a strong interest in tissue engineering and regenerative medicine. A willingness to learn new skills, high proficiency in English (written and spoken), and an independent work manner are highly valued for this position.

This is what we offer

• Opportunity to be part of a cutting-edge research project aimed at solving an unsolved challenge in regenerative medicine.
• Enhance your practical skills in material research, cell biology, and tissue engineering through hands-on experience with state-of-the-art techniques.
• An inclusive and team-oriented work environment in an international, dynamic setting.
• The guidance and support of an experienced team

We look forward to receiving your application!