Prof. Dr. Ulrich Schwaneberg
The Schwaneberg group has its core competence in protein engineering. At RWTH we combine directed evolution methodologies and rational design to discover fundamental design principles of proteins. At the DWI we employ engineered proteins to integrate functionalities into polymers. For instance, the adhesion promoting peptide platform employs adhesion promoting peptides that bind as (dense) monolayer on all kind of surfaces, including polymers, metal alloys, ceramics, plant leaves, teeth etc., at ambient temperature by simple dip coating in water. Adhesion promoter decorated surfaces are advanced to biohybrid systems through subsequent orthogonal sortase reactions or chemical conjugations. Specificity, binding strength and interactive properties are tailored through novel/developed directed evolution methodologies. Application areas comprise for instance release systems for plant as well as medical health (conjugated to microgels), in microplastic management and as (anti-microbial) surface coatings (as bifunctional fusion peptides).
Resume
Ulrich Schwaneberg studied chemistry at the University of Stuttgart and received his PhD under the supervision of Prof. R. D. Schmid, Institute of Technical Biochemistry at the University of Stuttgart. After his graduation in 1999, he was a post-doctoral fellow in the lab of Prof. F. H. Arnold at Caltech, Nobel laureate in 2018, for two years. In January 2002, he was appointed as professor at the Jacobs University Bremen. In 2009 he moved to RWTH Aachen University and became director of the Institute of Biotechnology. Since 2010 he is co-appointed at the DWI – Leibniz Institute for Interactive Materials. Notably, he is a member of the board of directors in the Bioeconomy Science Center and serves as speaker of the industry lab HICAST, the Henkel Innovation Campus for Advanced and Sustainable Technologies. He is a co-inventor on a number of patents of several improved enzymes, which have been transferred to industrial use. In 2008, he co-founded the SeSaM-Biotech GmbH, which offers directed evolution services. In 2013, he received a visiting professorship for senior international scientists of the Chinese Academy of Science, in 2015 a specially appointed professorship at Osaka University, in 2016 the 1.7 M € BMBF award for the Next Generation of Biotechnological Processes, and in 2018 the Innovation Award of the BioRegions in Germany for the greenRelease technology. He has a special interest in protein engineering and understanding underlying molecular principles, resulting in more than 220 manuscripts so far.
Selected professional functions, honors and awards
- 2022-2026: Speaker/Coordinator of the Bio4MatPro - Competence Centre for the Biological Transformation of Materials Science & Production Engineering (>50 partners; 26,3 Mio€)
- 2022-2026: Coordinator of the BioökonomieRevier – Innovation Labs ProtLabSF and PlastiQuant 2.0 (10 PIs; 5.4 Mio€; BMBF)
- Since 2021 Speaker of the RWTH profile area Molecular Science and Engineering
- Since 2020 Co-Chair der Division Biocatalysis in der European Federation of Biotechnology
- Since 2020 Member of the Advisory Board of CLIB (Cluster Industrial Biotechnology)
- Since 2019 Member of the Expert Council for Bioeconomy at MWIDE (Ministry of Economic Affairs, Innovation, Digitalization and Energy NRW)
- Since 2019 Coordinator of two innovation labs (InnoLabs ProtLab and PlastiQuant)
- 2016 BMBF Research Prize for the next generation of biotechnological processes (€ 1.75 million)
- 2015-2019 Spokesman of the Henkel Innovation Campus for Advanced and Sustainable Technologies HICAST (5 million € direct company funds)
- 2015 Specially appointed professor at Osaka University (visiting professorship)
- 2013/14 Visiting Professorship of Senior International Scientists of the Chinese Academy of Science (Sabbatical in 2014 at the TIB in Tianjin)
- Since 2010 Representative of the RWTH in the steering committee of the Bioeconomy Science Center (58,5 Mio €; 10-year project)
Publications
| Titel/Autoren | DOI-LINK | Magazine | Jahre | |
|---|---|---|---|---|
|
Effects of Proline Substitutions on the Thermostable LOV Domain from Chloroflexus aggregans
|
https://doi.org/10.3390/cryst10040256 | Crystals | 2020 | |
|
Engineered P450 BM3 and cpADH5 coupled cascade reaction for beta-oxo fatty acid methyl ester production in whole cells
|
https://doi.org/10.1016/j.enzmictec.2020.109555 | Enzyme and Microbial Technology | 2020 | |
|
Engineering of Laccase CueO for Improved Electron Transfer in Bioelectrocatalysis by Semi-Rational Design
|
https://doi.org/10.1002/chem.201905598 | Chemistry – A European Journal | 2020 | |
|
Engineering Robust Cellulases for Tailored Lignocellulosic Degradation Cocktails
|
https://doi.org/10.3390/ijms21051589 | International Journal of Molecular Sciences | 2020 | |
|
Enhancing Robustness of Sortase A by Loop Engineering and Backbone Cyclization
|
https://doi.org/10.1002/chem.202002740 | Chemistry-a European Journal | 2020 | |
|
Enzyme Hydration Determines Resistance in Organic Cosolvents
|
https://doi.org/10.1021/acscatal.0c03233 | ACS Catalysis | 2020 | |
|
FhuA-Grubbs-Hoveyda Biohybrid Catalyst Embedded in a Polymer Film Enables Catalysis in Neat Substrates
|
https://doi.org/10.1021/acscatal.0c03055 | ACS Catalysis | 2020 | |
|
How to Engineer Organic Solvent Resistant Enzymes: Insights from Combined Molecular Dynamics and Directed Evolution Study
|
https://doi.org/10.1002/cctc.202000422 | ChemCatChem | 2020 | |
|
Insights on intermolecular FMN-heme domain interaction and the role of linker length in cytochrome P450cin fusion proteins
|
https://doi.org/10.1515/hsz-2020-0134 | Biological Chemistry | 2020 | |
|
KnowVolution of a GH5 Cellulase from Penicillium verruculosum to Improve Thermal Stability for Biomass Degradation
|
https://doi.org/10.1021/acssuschemeng.0c02465 | Acs Sustainable Chemistry & Engineering | 2020 | |
|
Loop engineering of aryl sulfotransferase B for improving catalytic performance in regioselective sulfation
|
https://doi.org/10.1039/D0CY00063A | Catalysis Science & Technology | 2020 | |
|
MicroGelzymes: pH-Independent Immobilization of Cytochrome P450 BM3 in Microgels
|
https://doi.org/10.1021/acs.biomac.0c01262 | Biomacromolecules | 2020 |
