Prof. Dr. Ulrich Schwaneberg
The Schwaneberg group has its core competence in protein engineering. At RWTH we combine directed evolution methodologies and rational design to discover fundamental design principles of proteins. At the DWI we employ engineered proteins to integrate functionalities into polymers. For instance, the adhesion promoting peptide platform employs adhesion promoting peptides that bind as (dense) monolayer on all kind of surfaces, including polymers, metal alloys, ceramics, plant leaves, teeth etc., at ambient temperature by simple dip coating in water. Adhesion promoter decorated surfaces are advanced to biohybrid systems through subsequent orthogonal sortase reactions or chemical conjugations. Specificity, binding strength and interactive properties are tailored through novel/developed directed evolution methodologies. Application areas comprise for instance release systems for plant as well as medical health (conjugated to microgels), in microplastic management and as (anti-microbial) surface coatings (as bifunctional fusion peptides).
Resume
Ulrich Schwaneberg studied chemistry at the University of Stuttgart and received his PhD under the supervision of Prof. R. D. Schmid, Institute of Technical Biochemistry at the University of Stuttgart. After his graduation in 1999, he was a post-doctoral fellow in the lab of Prof. F. H. Arnold at Caltech, Nobel laureate in 2018, for two years. In January 2002, he was appointed as professor at the Jacobs University Bremen. In 2009 he moved to RWTH Aachen University and became director of the Institute of Biotechnology. Since 2010 he is co-appointed at the DWI – Leibniz Institute for Interactive Materials. Notably, he is a member of the board of directors in the Bioeconomy Science Center and serves as speaker of the industry lab HICAST, the Henkel Innovation Campus for Advanced and Sustainable Technologies. He is a co-inventor on a number of patents of several improved enzymes, which have been transferred to industrial use. In 2008, he co-founded the SeSaM-Biotech GmbH, which offers directed evolution services. In 2013, he received a visiting professorship for senior international scientists of the Chinese Academy of Science, in 2015 a specially appointed professorship at Osaka University, in 2016 the 1.7 M € BMBF award for the Next Generation of Biotechnological Processes, and in 2018 the Innovation Award of the BioRegions in Germany for the greenRelease technology. He has a special interest in protein engineering and understanding underlying molecular principles, resulting in more than 220 manuscripts so far.
Selected professional functions, honors and awards
- 2022-2026: Speaker/Coordinator of the Bio4MatPro - Competence Centre for the Biological Transformation of Materials Science & Production Engineering (>50 partners; 26,3 Mio€)
- 2022-2026: Coordinator of the BioökonomieRevier – Innovation Labs ProtLabSF and PlastiQuant 2.0 (10 PIs; 5.4 Mio€; BMBF)
- Since 2021 Speaker of the RWTH profile area Molecular Science and Engineering
- Since 2020 Co-Chair der Division Biocatalysis in der European Federation of Biotechnology
- Since 2020 Member of the Advisory Board of CLIB (Cluster Industrial Biotechnology)
- Since 2019 Member of the Expert Council for Bioeconomy at MWIDE (Ministry of Economic Affairs, Innovation, Digitalization and Energy NRW)
- Since 2019 Coordinator of two innovation labs (InnoLabs ProtLab and PlastiQuant)
- 2016 BMBF Research Prize for the next generation of biotechnological processes (€ 1.75 million)
- 2015-2019 Spokesman of the Henkel Innovation Campus for Advanced and Sustainable Technologies HICAST (5 million € direct company funds)
- 2015 Specially appointed professor at Osaka University (visiting professorship)
- 2013/14 Visiting Professorship of Senior International Scientists of the Chinese Academy of Science (Sabbatical in 2014 at the TIB in Tianjin)
- Since 2010 Representative of the RWTH in the steering committee of the Bioeconomy Science Center (58,5 Mio €; 10-year project)
Publications
| Titel/Autoren | DOI-LINK | Magazine | Jahre | |
|---|---|---|---|---|
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How Does Surface Charge Engineering of Bacillus subtilis Lipase A Improve Ionic Liquid Resistance? Lessons Learned from Molecular Dynamics Simulations
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https://doi.org/10.1021/acssuschemeng.1c07332 | ACS Sustainable Chemistry & Engineering | 2022 | |
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In Silico and Experimental Adam17 Kinetic Modeling as Basis for Future Screening System for Modulators
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https://doi.org/10.3390/ijms23031368 | International Journal of Molecular Sciences | 2022 | |
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Modulating the Coupling Efficiency of P450 BM3 by Controlling Water Diffusion through Access Tunnel Engineering
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https://doi.org/10.1002/cssc.202102434 | ChemSusChem | 2022 | |
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Optimized Hemolysin Type 1 Secretion System in Escherichia Coli by Directed Evolution of the Hly Enhancer Fragment and Including a Terminator Region
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https://doi.org/10.1002/cbic.202100702 | ChemBioChem | 2022 | |
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Plastibodies for Multiplexed Detection and Sorting of Microplastic Particles in High-Throughput
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https://doi.org/10.1016/j.scitotenv.2022.160450 | Science of The Total Environment | 2022 | |
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Polar Substitutions on the Surface of a Lipase Substantially Improve Tolerance in Organic Solvents
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https://doi.org/10.1002/cssc.202102551 | ChemSusChem | 2022 | |
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Preparative Production of Functionalized (N- and O-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor
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https://doi.org/10.3390/biom12020153 | Biomolecules | 2022 | |
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Rational Design Yields Molecular Insights on Leaf-Binding of Anchor Peptides
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https://doi.org/10.1021/acsami.2c00648 | ACS Applied Materials & Interfaces | 2022 | |
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Recombination of Single Beneficial Substitutions Obtained from Protein Engineering by Computer-Assisted Recombination (CompassR)
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https://doi.org/10.1007/978-1-0716-2152-3_2 | Directed Evolution: Methods and Protocols | 2022 | |
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Structure and Cooperativity in Substrate–Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design
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https://doi.org/10.1021/acschembio.1c00500 | ACS Chemical Biology | 2022 | |
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The Molecular Basis and Enzyme Engineering Strategies for Improvement of Coupling Efficiency in Cytochrome P450s
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https://doi.org/10.1016/j.biotechadv.2022.108051 | Biotechnology Advances | 2022 | |
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Using a Bio-Economic Farm Model to Evaluate the Economic Potential and Pesticide Load Reduction of the Greenrelease Technology
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https://doi.org/10.1016/j.agsy.2022.103454 | Agricultural Systems | 2022 |
