AnisoMatic

The AnisoMatic project aims to develop a scalable and automated platform for producing structured (anisotropic) three-dimensional hydrogels that better mimic the architecture of human tissues.

Current 3D cell culture models often lack controlled spatial organization, limiting their ability to accurately reproduce the structure and function of native tissues. This can reduce the predictive value of preclinical models for drug discovery, disease modeling, and toxicity testing. AnisoMatic addresses this challenge by introducing magnetically alignable microfibers (AnisoRods) into hydrogels. Using a magnetic plate (AnisoPlate), the fibers can be aligned in a controlled manner to guide cell organization and support the formation of more physiologically relevant tissue models.

The project focuses on scaling up the production of AnisoRods and integrating them into plate formats ranging from 96- to 1536-well plates, making the technology compatible with automated high-throughput workflows. The system will also be adapted for use with different natural and synthetic hydrogels and validated with relevant human cell types. The overall goal of the project is to establish a high-throughput, reproducible, and biologically relevant platform for structured 3D tissue models, with potential applications in drug discovery, disease modeling, toxicity testing, bioprinting, and regenerative medicine.