Thermoresponsive microgels offer interesting opportunities for molecular imaging and theranostic applications. They can serve as carrier materials, enabling controlled uptake and release of contrast agents and drugs. Furthermore, appropriate surface functionalization can endow them with targeting properties, allowing specific accumulation at defined cellular or tissue structures. 

A particularly promising strategy for signal enhancement in molecular imaging is para-hydrogen induced polarization (PHIP). This technique exploits the high nuclear spin order of para-hydrogen to boost NMR and MRI signals by several orders of magnitude. The resulting hyperpolarization enables substantially more sensitive detection; however, it is inherently time-limited, as the polarization decays via T1 relaxation within seconds to minutes. Moreover, most existing PHIP agents lack targeting capability. 

To address these challenges, we aim to merge the unique advantages of thermoresponsive microgels with hyperpolarization techniques to develop novel contrast agents for highly sensitive, non-invasive cell tissue imaging. Specifically, we aim to identify suitable markers for efficient hyperpolarization within the microgel network and to elucidate how the gel structure affects the corresponding hyperpolarization parameters. The project is divided into two parts: in the first part (supervised by the group of Prof. De Laporte), different microgels will be synthesized and functionalized. In the second part (supervised by the group of Prof. Herrmann), hyperpolarization efficiency will be assessed through NMR experiments, with the goal of achieving the longest possible hyperpolarization lifetime.

We are looking for a motivated student interested in exploring new effects at the interface of materials science and physical chemistry. Enthusiasm for both hands-on lab work and hyperpolarization/NMR analysis is essential. 

Task description:

• Synthesis and functionalization of microgels
• Characterization of microgels
• Investigation of NMR parameters such as T1
• NMR hyperpolarization experiments

What we offer:

• The opportunity to work at the interface of materials science, organic, and physical chemistry
• Enhance your practical skills in materials research
• Hands-on experience with NMR spectrometers
• An inclusive and team-oriented work environment in an international, dynamic setting. 
• The guidance and support of an experienced team
• Financial support for the master’s thesis (student assistant contract, subject to agreement)