Regulation of the epithelial-endothelial signaling interface

We examine the contribution of physiological shear stress on endothelial cells and soft substrate to the formation of the tight epithelial barrier. Conversely, we propose that pathologically low shear stress and stiff substrate lead to the generation of mediators that provoke inflammatory endothelial-epithelial crosstalk and elicit an inflammatory response with barrier disruption and leukocyte recruitment