Prof. Dr. Arnold Boersma
The Boersma group focusses on synthetic biochemistry, to engineer new proteins as well as larger cell-like systems. These systems are synthesized with specific applications in mind, which range from medical relevance (diagnosis, screening and/or understanding the basis of disease) to materials and devices. The group has especially a strong record of accomplishment on the design of FRET-based protein probes for macromolecular crowding in diverse living and nonliving systems and for ionic strength measurements. Current interests lie in the development of novel probes and cell-like systems to detect novel parameters in fields that range from biology to material science.
Resume
Dr. Arnold J. Boersma studied chemistry at the University of Groningen (The Netherlands) where he also pursued his graduate studies in the group of Prof. Ben L. Feringa (Nobel Laureate, 2016) and Prof. Gerard Roelfes. Here, he developed a new concept in catalysis by using DNA as an asymmetric catalyst. For this research, he was awarded the KNCV Catalysis prize for the best PhD thesis on catalysis in the Netherlands. He then worked as a postdoctoral fellow at Oxford University in the group of Prof. Hagan Bayley, funded by an NWO Rubicon grant. Here, he became an expert in protein engineering and lipid membranes. In 2012, he returned to the University of Groningen to become an independent researcher with an NWO Veni fellowship. Here, he developed novel probes to detect the physicochemical properties in various types of cells. Based on these research achievements he was awarded an NWO Vidi fellowship in 2016 to become a group leader. He joined the DWI-Leibniz Institute for Interactive Materials in August 2018.
Selected professional functions, honors and awards
- 2021 Fellow Max Planck School "Matter to Life"
- 2020 ACS Sensors selected "Rising stars in sensing"
- 2020 Consolidator Grant of the ERC
- 2016 Vidi grant der Netherlands Organization for Scientific Research (NWO)
- 2012 Veni grant of the NOW
- 2011 KNCV Catalysis prize for the best doctoral thesis in the field of catalysis in the Netherlands in 2009-2010
- 2009 Presentation of the "Cum Laude" award (top 5%) for the doctoral thesis
- 2009 Rubicon grant of the NOW
Publications
| Titel/Autoren | DOI-LINK | Magazine | Jahre | |
|---|---|---|---|---|
|
Controlling Optical and Catalytic Activity of Genetically Engineered Proteins by Ultrasound
Y. Zhou, S. Huo, M. Loznik, R. Göstl, A. J. Boersma and A. Herrmann
|
https://doi.org/10.1002/anie.202010324 | Angewandte Chemie International Edition | 2020 | |
|
FRET Analysis of Ionic Strength Sensors in the Hofmeister Series of Salt Solutions Using Fluorescence Lifetime Measurements
R. Miller, C. Aplin, T. Kay, R. Leighton, C. Libal, R. Simonet, A. Cembran, A. Heikal, A. Boersma and E. Sheets
|
https://doi.org/10.1021/acs.jpcb.9b10498 | The Journal of Physical Chemistry B | 2020 | |
|
Investigating Novel Hetero-FRET Biosensors for Environmental Ionic Strength using Experimental and Theoretical Approaches
C. P. Aplin, R. C. Miller, T. M. Kay, A. Cembran, A. J. Boersma, A. A. Heikal, E. D. Sheets
|
https://doi.org/10.1016/j.bpj.2019.11.2798 | Biophysical Journal | 2020 | |
|
Modular and Versatile Trans-Encoded Genetic Switches
A. Paul, E. M. Warszawik, M. Loznik, A. J. Boersma and A. Herrmann
|
https://doi.org/10.1002/anie.202001372 | Angewandte Chemie International Edition | 2020 | |
|
Single-Molecule Studies of Hetero-FRET Biosensors to Environmental Ionic Strength using Different Modalities of Fluorescence Correlation Spectroscopy
T. M. Kay, C. Libal, C. P. Aplin, A. J. Boersma, E. D. Sheets and A. A. Heikal
|
https://doi.org/10.1016/j.bpj.2019.11.3322 | Biophysical Journal | 2020 | |
|
Supercharged Proteins and Polypeptides
C. Ma, A. Malessa, A. J. Boersma, K. Liu and A. Herrmann
|
https://doi.org/10.1002/adma.201905309 | Advanced Materials | 2020 | |
|
The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes
M. Löwe, M. Kalacheva, A. J. Boersma and A. Kedrov
|
https://doi.org/10.1111/febs.15429 | The FEBS Journal | 2020 | |
|
A Trifunctional Linker for Palmitoylation and Peptide and Protein Localization in Biological Membranes
Ł. Syga, R. H. de Vries, H. van Oosterhout, R. Bartelds, A. J. Boersma, G. Roelfes and B. Poolman
|
https://doi.org/10.1002/cbic.201900655 | ChemBioChem | 2019 | |
|
Crowding Effects on Energy-Transfer Efficiencies of Hetero-FRET Probes As Measured Using Time-Resolved Fluorescence Anisotropy
H. J. Leopold, R. Leighton, J. Schwarz, A. J. Boersma, E. D. Sheets and A. A. Heikal
|
https://doi.org/10.1021/acs.jpcb.8b09829 | Journal of Physical Chemistry B | 2019 | |
|
Decreased Effective Macromolecular Crowding in Escherichia coli Adapted to Hyperosmotic Stress
B. Q. Liu, Z. Hasrat, B. Poolman and A. J. Boersma
|
https://doi.org/10.1128/JB.00708-18 | Journal of Bacteriology | 2019 | |
|
DNA Nanotechnology Enters Cell Membranes
S. Huo, H. Li, A. J. Boersma and A. Herrmann
|
https://doi.org/10.1002/advs.201900043 | Advanced Science | 2019 | |
|
Macromolecular crowding effects on energy transfer efficiency and donor-acceptor distance of hetero-FRET sensors using time-resolved fluorescence; ARTN 025002
J. L. Schwarz, H. J.; Leighton, R.; Miller, R. C.; Aplin, C. P.; Boersma, A. J.; Heikal, A. A.; Sheets, E. D.
|
https://www.doi.org/10.1088/2050-6120/ab0242 | Methods and Applications in Fluorescence | 2019 |