Dr. Jacopo Di Russo
Jacopo Di Russo’s research aims to understand the interplay of extracellular matrix biochemical and physical information in controlling epithelial mechanobiology.
Epithelia are sheets of cells self-organized either as a simple single-cell monolayer or as complex 3D structures. Their structures and functions are not defined by biochemical processes alone, but they are also highly dependent on their physical characteristics. These are emerging properties of cell collectives, not predictable from the single cell biomechanics.
Jacopo Di Russo’s group studies epithelia mechanobiology with interdisciplinary experimental approaches including hydrogels technologies, organoids and mouse biology.
Curriculum Vitae
Jacopo Di Russo studied cell biology in Florence (Italy) for then joining the laboratory of Prof. Lydia Sorokin in Muenster (Germany) as Marie Curie Fellow. There he studied how extracellular matrix influences physiological responses. In 2015 he joined the laboratory of Prof. Joachim Spatz at the Max Planck Institute for Medical Research in Heidelberg (Germany) deepening his knowledge on cell adhesion at biophysical levels. Since 2019 he is an independent group leader at the Interdisciplinary Center for Clinical Research of the RWTH Aachen.
Publications
| Titel/Autoren | DOI-LINK | Magazine | Jahre | |
|---|---|---|---|---|
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A Keratin Code Defines the Textile Nature of Epithelial Tissue Architecture
J. Di Russo, T. M. Magin and R. E. Leube
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https://doi.org/10.1016/j.ceb.2023.102236 | Current Opinion in Cell Biology | 2023 | |
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Actuation of Soft Thermoresponsive Hydrogels Mechanically Stimulates Osteogenesis in Human Mesenchymal Stem Cells without Biochemical Factors
A. Castro Nava, I. C. Doolaar, N. Labude-Weber, H. Malyaran, S. Babu, Y. Chandorkar, J. Di Russo, S. Neuss and L. De Laporte
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https://doi.org/10.1021/acsami.3c11808 | ACS Applied Materials & Interfaces | 2023 | |
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Mechanobiological Implications of Age-Related Remodelling in the Outer Retina
T. Piskova, A. N. Kozyrina and J. Di Russo
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https://doi.org/10.1016/j.bioadv.2023.213343 | Biomaterials Advances | 2023 | |
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Cells Feel the Beat – Temporal Effect of Cyclic Mechanical Actuation on Muscle Cells
Y. Chandorkar, C. Bastard, J. Di Russo, T. Haraszti and L. De Laporte
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https://doi.org/10.1016/j.apmt.2022.101492 | Applied Materials Today | 2022 | |
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Combining Image Restoration and Traction Force Microscopy to Study Extracellular Matrix-Dependent Keratin Filament Network Plasticity
S. Yoon, R. Windoffer, A. N. Kozyrina, T. Piskova, J. Di Russo and R. E. Leube
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https://doi.org/10.3389/fcell.2022.901038 | Frontiers in Cell and Developmental Biology | 2022 | |
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How do the Local Physical, Biochemical, and Mechanical Properties of an Injectable Synthetic Anisotropic Hydrogel Affect Oriented Nerve Growth?
S. Babu, I. Chen, S. Vedaraman, J. Gerardo-Nava, C. Licht, Y. Kittel, T. Haraszti, J. Di Russo and L. De Laporte
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https://doi.org/10.1002/adfm.202202468 | Advanced Functional Materials | 2022 | |
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Integrin Α5β1 Nano-Presentation Regulates Collective Keratinocyte Migration Independent of Substrate Rigidity
J. Di Russo, J. L. Young, J. W. R. Wegner, T. Steins, H. Kessler and J. P. Spatz
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https://doi.org/10.7554/eLife.69861 | eLife | 2021 | |
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Mechanobiology of Epithelia From the Perspective of Extracellular Matrix Heterogeneity
A. N. Kozyrina, T. Piskova and J. Di Russo
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https://doi.org/10.3389/fbioe.2020.596599 | Frontiers in Bioengineering and Biotechnology | 2020 | |
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The role of basement membrane laminins in vascular function
R. Hallmann, M. J. Hannocks, J. Song, X. L. Zhang, J. Di Russo, A. L. Luik, M. Burmeister, H. Gerwien and L. Sorokin
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https://doi.org/10.1016/j.biocel.2020.105823 | International Journal of Biochemistry & Cell Biology | 2020 |