Exciting Advances in Sonogenetics and Sonopharmacology

It all started in 2021 with the first publication in Nature Chemistry and since then a lot has happened in the fields of sonopharmacology and sonogenetics at the DWI...

In their recent publication in the journal Advanced Materials, Aman Ishaqat, Johannes Hahmann, Cheng Lin, Xiaofeng Zhang, Chuanjiang He, Wolfgang H. Rath, Pardes Habib, Sabri E. M. Sahnoun, Khosrow Rahimi, Rostislav Vinokur, Felix M. Mottaghy, Robert Göstl, Matthias Bartneck and Andreas Herrmann transferred the conceptual framework of polymer mechanochemistry to in vivo applications, in particular immunostimulation, using medically approved imaging ultrasound . They also validated the sonogenic function of their system by achieving gene knockdown in mammalian cell cultures. This proof of concept paves the way for broad therapeutic applications in various diseases.

We also recommend the current review article by Johannes Hahmann, Aman Ishaqat, Twan Lammers and Andreas Herrmann in Angewandte Chemie International Edition.

The authors emphasize the potential of sonogenetics, a cutting-edge technique that uses ultrasound to control and monitor cell function. By combining genetic engineering and ultrasound, this approach offers non-invasive and precise manipulation of cells. From imaging to therapy, sonogenetics surpasses the limits of optogenetics and magnetogenetics by penetrating deep into the tissue and offering high spatial and temporal control.

We are curious to see what else is coming...