ReWire

Technologiegestützte Kombinationstherapie zur Wiederherstellung von Nervenverbindungen im Rückenmark nach Verletzungen

Das europäische Doktorandennetzwerk ReWire startete mit 16 offenen Doktorandenstellen in Europa (10), Großbritannien (2) und der Schweiz (4), um innovative translationale Neurotechnologien und Rehabilitationsmaßnahmen zur Wiederherstellung neurologischer Funktionen nach Rückenmarksverletzungen zu kombinieren. Namenhafte Leiter des gemeinsamen Projektes sind G. Courtine, Stephanie Lacour, Jocelyn Bloch, Armin CurtCatherine Jutzeler, Elizabeth Bradbury, Simone Di Giovanni, Patricia Y.W. Dankers, Hoc Khiem Trieu, Silvestro Micera, ONWARD, Fonds de dotation Clinatec, Wearable Robotics, Biosynth, Veronica Estrada, Jose Luis Gerardo Nava und Laura De Laporte.

Promovierende in ReWIRE

Carlo Carraro

MSCA-funded fellow

Carlo Carraro

Carlo Carraro is from Italy and recently completed his Master’s degree in Bioengineering at Politecnico di Milano, where he specialized in electronics and wearable device technologies. Currently, he is pursuing a PhD under theguidance of Prof. Dr.-Ing. Vallery Heike (Instituteof Automatic Control, RWTH Aachen University) and Dr. Joachim von Zitzewitz (ONWARD Medical). His research focuses on developing personalized orthosis and sensor/control platforms for movement intention recognition, both with the goal to improve EES-supported (Epidural Electrical Stimulation) locomotion for people with spinal cord injury.

Rui Chen

MSCA-funded fellow

Rui Chen

Rui Chen was born in China and obtained his MSc degree from Tsinghua University in Mechanical Engineering, and another MSc degree from RWTH Aachen University in Product System Engineering. He began working as a PhD student at Wearable Robotics in Italy under the supervision of Professor Antonio Frisoli. His work will focus on the development of a robotic soft exoskeleton for gross manipulation restoration after spinal cord injury.

Simay Genişcan

UKRI-funded fellow

Simay Genişcan

Simay Genişcan is from Turkey, Izmir, and completed her Master’s degree in Neuroscience in Ajou University, South Korea. She is workingin the lab of Prof. Elizabeth Bradbury at King’s College. With a focus in spinal cord repair, she has been utilizing different approaches to regenerate damaged spinal cord, including cell and organoid transplantation, biomaterial injection, and modulation of inhibitory spinal cord ECM environment with therapeutic drugs. Her thesis project is on an in vitro scar model with primary fibroblasts and astrocytes and screened drugs that can modulate fibrosis.

Paula Holban

MSCA-funded fellow

Paula Holban

Paula Holban was born in Moldova and studied Chemistry of Complex Systems in Strasbourg, France. During her Master’s, she contributed to several research projects ranging from biochemistry to photochemistry. In October, she started her PhD journey in Biomedical Engineering at the University of Technology in Eindhoven (TU/e), under the guidance of Prof. Patricia Dankers. She will focus on developing injectable supramolecular biomaterials to promote axonal growth following spinal cord injury.

Alessandro Ippoliti

MSCA-funded fellow

Alessandro Ippoliti

Alessandro Ippoliti was born in Milan and studied at the Politecnico di Milano where he obtained a Bachelor’s degree in Engineering Physics and a Master’s in Biomedical Engineering. His thesis was conducted at the “Institut de Ciències Fotòniques”(ICFO) in Barcellona under Dr. Turgut Durduran. In May, he began in the ReWIRE program at TUHH under the supervision of Prof. Kim Trieu, with a focus on looking to build fully biocompatible and biodegradable spinal implants out of hydrogels through a stereolithographic technique called “two photon polymerization” (2PP). This is done with the scope of promoting spinal cord regeneration after traumatic injuries.

Maria Justino

MSCA-funded fellow

Maria Justino

Maria Justino is a PhD student at Clinatec and the main objectives of her program are to establish novel algorithms of intended movement decoding from epidural cortical (brain) recording to provide corresponding stimulation patterns to central or periphery nervous system aiming at recovering motor control after spinal cord injury in humans. She looks forward to expanding her competencies in designing appropriate acquisition systems, acquiring and processing data, establishing new datasets, data imaging and visualization, and developing interpretable and accurate machine learning models.

Navami Prabhakar Koyande

SERI-funded fellow

Navami Prabhakar Koyande

Navami Prabhakar Koyande was born in Mumbai, India and obtained her MSc degree in Biotechnology from University of Mumbai. She will start working as a PhD student at Biosynth, Lelystad under the supervision of Prof. Dr. PeterTimmerman (Biosynth) and Prof. Dr.-Ing. Laura De Laporte (RWTH Aachen University). She will work on developing high-affinity CLIPSTM peptides that mimic functions of cell adhesive proteins, like laminins, to support in vitro and in vivo cell and nerve attachment and migration.

Elif Önsöz

MSCA-funded fellow

Elif Önsöz

Elif Önsöz is from Turkey and received a Bachelor’s degree in Molecular Biology and Genetics. She obtained an MSc in Neurobiology at Unito and in Stem Cell and Regenerative Medicine at Mersin University. She will start at DWI in the De Laporte lab under the supervision of Dr. Veronica Estrada. Her PhD project will focus on the in vivo application of the Advanced Mechanical Microconnector System (mMS+) to improve the outcome of acute and chronic spinal cord injury.

Firman Isma Serdana

MSCA-funded fellow

Firman Isma Serdana

Firman Isma Serdana is a Biomedical Engineer with a passion for neuroengineering on the application of bio-signal processing and machine learning for system control. His research focus is on the utilization of hand and arm electromyography signals for robotics control and rehabilitation. A recent project used high-density EMG to reproduce discrete finger control (Serdana et al., 2022 & 2023) under the supervision of Prof. Dario Farina and Dr. Silvia Muceli. He graduated with a B.Eng. in Biomedical Engineering from Airlangga University and also received an MSc in Human and Biological Robotics at Imperial College London.

Yayue Song

UKRI-funded fellow

Yayue Song

Yayue Song is from Beijing, China, and studied medicine in China. She completed her MSc degreein Translational Neuroscience at Imperial College London, under the guidance of Professor Simone Di Giovanni. Yayue is undertaking a PhD project at Imperial College London under the supervision of Professor Simone Di Giovanni, with a focus on investigating the molecular mechanisms that promote regeneration and repair following spinal cord injuries. Within the consortium, she aims to combine the molecular stimulation of neuronal regeneration with biomaterials or other combinatorial approaches to enhance the repair potential after spinal injury.

Catarina Tavares

MSCA-funded fellow

Catarina Tavares

Catarina Tavares, from Portugal, obtained her MSc degree in Nanotechnology Engineering at the NOVA Faculty of Science and Technology. She is pursuing a PhD under the supervision of Prof. Dr.-Ing. Laura De Laporte at DWI (RWTH Aachen University), focusing on the microfluidic production of microgel capsules as drug delivery systems and the sustained release of growth factors to promote spinal cord regeneration after injury. Since starting in September, she has been conducting a literature review on sustained or stimuli-triggered drug delivery systems based on microgels and on the effects of local growth factor release for neural regeneration.

Miklovana Tuci

SERI-funded fellow

Miklovana Tuci

Miklovana Tuci was born in Albania and obtained her MSc in Machine Learning at KTH Royal Institute of Technology, Sweden. Her master’s thesis focused on Representation Learning and Manifold Learning. In June 2023, she joined the Biomedical Data Science Lab at ETH Zurich as a PhD student, under the supervision of Prof.Catherine Jutzeler, and will work at the Balgrist research campus, under the co-supervision of PD Dr. Marco Bolliger. She will focus on applying machine learning techniques to counsel preclinical research and to advance translational trial protocols in human spinal cord injury.

Jace Vu

MSCA-funded fellow

Jace Vu

Jace Vu graduated with a BSc in Chemical Engineering at Miami University, USA, and an MSc in Bioengineering at the University of California, Los Angeles, USA. He will start his doctoral research in the Advanced Materials for Biomedicine research group led by Dr.-Ing. Laura De Laporte at the DWI Leibniz Institute for Interactive Materials. He will be working on developing and evaluating injectable, magneto-responsive, macroporous guiding scaffolds as therapy after acute SCI.

Bianca Yu

SERI-funded fellow

Bianca Yu

Bianca Yu, from the United States, recently completed her Master’s degree in Bioengineering at Stanford University, where she specialized in electromechanical engineering, robotics, and clinical technology. She is joining the NeuroRestore laboratory at Lausanne University Hospital (CHUV / Centre hospitalier universitaire vaudois) in Switzerland to begin her PhD in Neuroscience. Her research will focus on optimizing brain-controlled epidural electrical stimulation to restore movement and neurological function in patients with upper-limb paralysis caused by cervical spinal cord injury.

Scott Erickson

SERI-funded fellow

Scott Erickson

Scott Erickson is a PhD student working under Prof. Stéphanie Lacour in the Laboratory for Soft Bioelectronic Interfaces (LSBI) at EPFL. In the past he has worked on developing in vitro models of placental and cerebral vasculature. He is now working on designing and fabricating microelectrode arrays for recording electrophysiological activity of human spinal cord organoids with the goal of developing an in vitro model of spinal cord injury.

Vi Anh Nguyen

SERI-funded fellow

Vi Anh Nguyen

Vi Anh Nguyen was born in Paris, France and obtained her MSc degree in Neuroscience and in Bioengineering & Innovation in Neuroscience from Université Paris Cité. Her academic background has been centered on the use of neuroprosthetic implants for functional recovery. During her previous research internships, she investigated the functionality of subretinal implants for vision restoration after retinitis pigmentosa and age-related macular degeneration. Naturally extending this interest, Vi Anh joined the .NeuroRestore laboratory at EPFL under the supervision of Professor Grégoire Courtine. Her PhD project focuses on restoring lower urinary tract function after spinal cord injury using epidural electrical stimulation (EES) and understanding the mechanisms by which EES modulates bladder and sphincter control. As part of the ReWIRE network, Vi Anh aims to contribute to developing neuromodulatory strategies that translate into improved quality of life for individuals living with spinal cord injury.

Former Fellows

Tristan Tarasi

MSCA-funded fellow (30.01.-31.10.2023)

Tristan Tarasi

Tristan Tarasi joined ONWARD as part of the ReWIRE program. Epidural electrical stimulation (EES) is a promising technique used to help restore movement and function in individuals with spinal cord injury (SCI). The main goal of his project was to develop solutions that enhance rehabilitation with EES. His thesis focused on two main areas. The first involves the development of sensors and real-time algorithms for motion intention recognition in combination with personalized EES. The second focused on investigating state-of-the-art orthoses and their potential to improve mobility in conjunction with EES.