The research of our group focuses on synthetic chemistry and molecular biology. Chemists, biologists and physicists are dedicated to the task of inventing new molecular technologies to create new (bio)molecular and biohybrid structures by combining chemical and biological processes. Our group has pioneered the development of two classes of materials: nucleic acid polymer conjugates and supercharged polypeptides. Inspired by nature, these materials are designed to form well-defined molecular architectures that span multiple length scales from nanometer to macroscopic structures. These structures are key for the realization of complex functions in technological, medical and life science applications.
Sonopharmacology: Our group was the first to transfer concepts from polymer mechanochemistry to the life sciences. Ultrasound and the resulting shear forces in aqueous environment act as external trigger to activate different classes of drug molecules realizing a novel concept for precision targeting medicines.
D. Yiliz, R. Göstl & A. Herrmann: Chem. Sci. 2022, 13: 13708-13719
S. Huo et al.: Nat. Chem. 2021, 13: 131-139
Sonogenetics: Besides switching on active pharmaceutical ingredients by ultrasound, we exploit this trigger to manipulate the activity of proteins and genes. Enzymes and nucleic acids are designed to respond to low intensity biocompatible ultrasound to remotely orchestrate biological systems deep inside the body in the future.
J. Hahmann et al.: Angew. Chem. Int. Ed. 2024, e202317112
P. Zhao et al.: Angew. Chem. Int. Ed. 2021, 60(26): 14707-14714
Ultrastrong Bioadhesives: We design molecular glues de novo by exploiting recombinant protein expression and genetic engineering. Supercharged polypeptides were complexed with surfactants to form coacervate-based adhesives with outstanding features such as temperature switchability, hemostatic and wound healing promoting properties.
Y. Zhou et al.: Adv. Mater. 2023, 35(16): 2210052
C. Ma et al.: Nat. Commun. 2021, 12: 3613
Prof. Dr. Andreas Herrmann
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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On the Mucoadhesive Properties of Synthetic and Natural Polyampholytes
M. Fu, S. K. Filippov, A. C. Williams and V. V. Khutoryanskiy
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https://doi.org/10.1016/j.jcis.2023.12.176 | Journal of Colloid and Interface Science | 2024 | |
Shape Morphing of Hydrogels by Harnessing Enzyme Enabled Mechanoresponse
K. Zhang, Y. Zhou, J. Zhang, Q. Liu, C. Hanenberg, A. Mourran, X. Wang, X. Gao, Y. Cao, A. Herrmann and L. Zheng
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https://doi.org/10.1038/s41467-023-44607-y | Nature Communications | 2024 | |
Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound
J. Hahmann, A. Ishaqat, T. Lammers and A. Herrmann
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https://doi.org/10.1002/anie.202317112 | Angewandte Chemie International Edition | 2024 | |
Biochemical and Structural Insight into the Chemical Resistance and Cofactor Specificity of the Formate Dehydrogenase from Starkeya Novella
M. Partipilo, J. J. Whittaker, N. Pontillo, J. Coenradij, A. Herrmann, A. Guskov and D. J. Slotboom
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https://doi.org/10.1111/febs.16871 | The FEBS Journal | 2023 | |
Fracture Detection in Bio-Glues with Fluorescent-Protein-Based Optical Force Probes
Y. Zhou, S. P. Centeno, K. Zhang, L. Zheng, R. Göstl and A. Herrmann
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https://doi.org/10.1002/adma.202210052 | Advanced Materials | 2023 | |
Lipid-DNA Nanoparticles as Drug-Delivery Vehicles for the Treatment of Retinal Diseases
S. Schnichels, D. Simmang, M. Löscher, A. Herrmann, J. W. de Vries, M. S. Spitzer and J. Hurst
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https://doi.org/10.3390/pharmaceutics15020532 | Pharmaceutics | 2023 | |
Nanopore Detection Using Supercharged Polypeptide Molecular Carriers
X. Wang, T.-M. Thomas, R. Ren, Y. Zhou, P. Zhang, J. Li, S. Cai, K. Liu, A. P. Ivanov, A. Herrmann and J. B. Edel
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https://doi.org/10.1021/jacs.2c13465 | Journal of the American Chemical Society | 2023 | |
NMR in Operando Monitoring of Mechanochemically Accelerated Sublimations
F. Puccetti, T. Rinesch, S. Suljić, K. Rahimi, A. Herrmann and C. Bolm
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https://doi.org/10.1016/j.chempr.2023.02.022 | Chem | 2023 | |
Parahydrogen-Induced Polarization of a Labeled, Cancer-Targeting DNA Aptamer
K.-O. Brenske, M. Emondts, S. T. Hörnig, S. Panitz, M. I. Pieper, A. Ligori, A. Schacht, J. Henkel, J. Klankermayer and A. Herrmann
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https://doi.org/10.1002/anie.202300531 | Angewandte Chemie International Edition | 2023 | |
Polymer Mechanochemistry in Microbubbles
M. Xuan, J. Fan, V. N. Khiêm, M. Zou, K.-O. Brenske, A. Mourran, R. Vinokur, L. Zheng, M. Itskov, R. Göstl and A. Herrmann
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https://doi.org/10.1002/adma.202305130 | Advanced Materials | 2023 | |
Polymeric Materials for Ultrasound Imaging and Therapy
R. A. Barmin, M. Moosavifar, A. Dasgupta, A. Herrmann, F. Kiessling, R. M. Pallares and T. Lammers
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https://doi.org/10.1039/D3SC04339H | Chemical Science | 2023 | |
Programming DNA Circuits for Controlled Immunostimulation through Cpg Oligodeoxynucleotide Delivery
A. Ishaqat, X. Zhang, Q. Liu, L. Zheng and A. Herrmann
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https://doi.org/10.1021/jacs.2c09359 | Journal of the American Chemical Society | 2023 |