The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Prof. Dr. Ulrich Schwaneberg
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
---|---|---|---|---|
Fhua: From Iron-Transporting Transmembrane Protein to Versatile Scaffolds through Protein Engineering
D. F. Sauer, U. Markel, J. Schiffels, J. Okuda and U. Schwaneberg
|
https://doi.org/10.1021/acs.accounts.3c00060 | Accounts of Chemical Research | 2023 | |
In Situ Monitoring of Membrane Protein Insertion into Block Copolymer Vesicle Membranes and Their Spreading via Potential-Assisted Approach
T. Mirzaei Garakani, Z. Liu, U. Glebe, J. Gehrmann, J. Lazar, M. A. S. Mertens, M. Moller, N. Hamzelui, L. Zhu, U. Schnakenberg, A. Boker and U. Schwaneberg
|
https://www.doi.org/10.1021/acsami.9b09302 | ACS Appl Mater Interfaces | 2019 | |
Rapid and Robust Coating Method to Render Polydimethylsiloxane Surfaces Cell-Adhesive
D. B. Gehlen, L. C. De Lencastre Novaes, W. Long, A. J. Ruff, F. Jakob, T. Haraszti, Y. Chandorkar, L. Yang, P. van Rijn, U. Schwaneberg and L. De Laporte
|
https://www.doi.org/10.1021/acsami.9b16025 | ACS Appl Mater Interfaces | 2019 | |
Rational Design Yields Molecular Insights on Leaf-Binding of Anchor Peptides
J. Dittrich, C. Brethauer, L. Goncharenko, J. Bührmann, V. Zeisler-Diehl, S. Pariyar, F. Jakob, T. Kurkina, L. Schreiber, U. Schwaneberg and H. Gohlke
|
https://doi.org/10.1021/acsami.2c00648 | ACS Applied Materials & Interfaces | 2022 | |
A Whole Cell E. coli Display Platform for Artificial Metalloenzymes: Poly(phenylacetylene) Production with a Rhodium-Nitrobindin Metalloprotein
A. R. Grimm, D. F. Sauer, T. Polen, L. L. Zhu, T. Hayashi, J. Okuda and U. Schwaneberg
|
https://www.doi.org/10.1021/acscatal.7b04369 | Acs Catalysis | 2018 | |
Cavity Size Engineering of a β-Barrel Protein Generates Efficient Biohybrid Catalysts for Olefin Metathesis
A. R. Grimm, D. F. Sauer, M. D. Davari, L. L. Zhu, M. Bocola, S. Kato, A. Onoda, T. Hayashi, J. Okuda and U. Schwaneberg
|
https://www.doi.org/10.1021/acscatal.7b03652 | Acs Catalysis | 2018 | |
Chemogenetic Evolution of a Peroxidase-like Artificial Metalloenzyme
U. Markel, D. F. Sauer, M. Wittwer, J. Schiffels, H. Cui, M. D. Davari, K. W. Kröckert, S. Herres-Pawlis, J. Okuda and U. Schwaneberg
|
https://doi.org/10.1021/acscatal.1c00134 | ACS Catalysis | 2021 | |
Directed Evolution of Material Binding Peptide for Polylactic Acid-Specific Degradation in Mixed Plastic Wastes
Y. Lu, K.-W. Hintzen, T. Kurkina, Y. Ji and U. Schwaneberg
|
https://doi.org/10.1021/acscatal.3c02142 | ACS Catalysis | 2023 | |
Enzyme Hydration Determines Resistance in Organic Cosolvents
H. Cui, L. Zhang, L. Eltoukhy, Q. Jiang, S. K. Korkunç, K.-E. Jaeger, U. Schwaneberg and M. D. Davari
|
https://doi.org/10.1021/acscatal.0c03233 | ACS Catalysis | 2020 | |
Enzyme-Polyelectrolyte Complexes Boost the Catalytic Performance of Enzymes
M. J. Thiele, M. D. Davari, M. Konig, I. Hofmann, N. O. Junker, T. M. Garakani, L. Vojcic, J. Fitter and U. Schwaneberg
|
https://www.doi.org/10.1021/acscatal.8b02935 | Acs Catalysis | 2018 | |
FhuA-Grubbs-Hoveyda Biohybrid Catalyst Embedded in a Polymer Film Enables Catalysis in Neat Substrates
T. M. Garakani, D. F. Sauer, M. A. S. Mertens, J. Lazar, J. Gehrmann, M. Arlt, J. Schiffels, U. Schnakenberg, J. Okuda and U. Schwaneberg
|
https://doi.org/10.1021/acscatal.0c03055 | ACS Catalysis | 2020 | |
Flexibility Regulation of Loops Surrounding the Tunnel Entrance in Cytochrome P450 Enhanced Substrate Access Substantially
Z. Li, S. Meng, K. Nie, U. Schwaneberg, M. D. Davari, H. Xu, Y. Ji and L. Liu
|
https://doi.org/10.1021/acscatal.2c02258 | ACS Catalysis | 2022 |