The Rodriguez-Emmenegger group aims at the development of adaptive biointerfaces and protocells able to interact and direct synthetic and natural systems. Towards this aim, they develop routes to tailor the topology and architecture of synthetic and hybrid macromolecules and program their intermolecular interactions to drive the hierarchical directed self-assembly into interfaces and materials capable to selectively and actively (autonomously) alter their properties to environmental cues —biological and artificial. Furthermore, they investigate, how to achieve superselective interfaces by balancing repellency in aqueous systems with multivalent and cooperative attractive interactions.
The Rodriguez-Emmenegger group strives for translating their basic research into adaptive hemocompatible coatings, antimicrobial wound dressings and diagnostic tools. They are also developing new concepts for cell membrane mimics and protocellular systems capable of communicating with living cells and directing their behavior by the exploitation of biophysical and biochemical actions.
Prof. Dr. César Rodriguez-Emmenegger
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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A Green Solvent-to-Polymer Upgrading Approach to Water-Soluble LCST Poly(N-Substituted Lactamide Acrylate)s
M. Palà, H. El Khannaji, M. Garay-Sarmiento, J. C. Ronda, V. Cádiz, M. Galià, V. Percec, C. Rodriguez-Emmenegger and G. Lligadas
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https://doi.org/10.1039/D2GC02780A | Green Chemistry | 2022 | |
An engineered coccolith-based hybrid that transforms light into swarming motion
M. Lomora, A. Larrañaga, C. Rodriguez-Emmenegger, B. Rodriguez, I. A. Dinu, J.-R. Sarasua and A. Pandit
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https://doi.org/10.1016/j.xcrp.2021.100373 | Cell Reports Physical Science | 2021 | |
Biointerfaces and Biopolymers
C. Rodriguez-Emmenegger and H. Zuilhof
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https://doi.org/10.1002/admi.202202252 | Advanced Materials Interfaces | 2022 | |
Brush-Like Coatings Provide a Cloak of Invisibility to Titanium Implants
L. Witzdam, M. Garay-Sarmiento, M. Gagliardi, Y. L. Meurer, Y. Rutsch, J. Englert, S. Philipsen, A. Janem, R. Alsheghri, F. Jakob, D. G. M. Molin, U. Schwaneberg, N. M. S. van den Akker and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202300434 | Macromolecular Bioscience | 2023 | |
Brush-Like Interface on Surface-Attached Hydrogels Repels Proteins and Bacteria
L. Witzdam, Y. L. Meurer, M. Garay-Sarmiento, M. Vorobii, D. Söder, J. Quandt, T. Haraszti and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202200025 | Macromolecular Bioscience | 2022 | |
Complement Activation Dramatically Accelerates Blood Plasma Fouling on Antifouling Poly(2-Hydroxyethyl Methacrylate) Brush Surfaces
T. Riedel, A. de los Santos Pereira, J. Táborská, Z. Riedelová, O. Pop-Georgievski, P. Májek, K. Pečánková and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202100460 | Macromolecular Bioscience | 2021 | |
Controlled Surface Adhesion of Macrophages via Patterned Antifouling Polymer Brushes
M. Vorobii, C. Rodriguez-Emmenegger
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https://doi.org/10.1002/anbr.202000029 | Advanced NanoBiomed Research | 2020 | |
Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria
A. M. Wagner, H. Eto, A. Joseph, S. Kohyama, T. Haraszti, R. A. Zamora, M. Vorobii, M. I. Giannotti, P. Schwille and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/adma.202202364 | Advanced Materials | 2022 | |
Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms
S. Li, B. Xia, B. Javed, W. D. Hasley, A. Melendez-Davila, M. Liu, M. Kerzner, S. Agarwal, Q. Xiao, P. Torre, J. G. Bermudez, K. Rahimi, N. Y. Kostina, M. Möller, C. Rodriguez-Emmenegger, M. L. Klein, V. Percec and M. C. Good
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https://doi.org/10.1021/acsnano.0c02912 | ACS Nano | 2020 | |
Efficacy of A Poly(MeOEGMA) Brush on the Prevention of Escherichia coli Biofilm Formation and Susceptibility
P. Alves, L. Gomes, C. Rodríguez-Emmenegger and Filipe José Mergulhão
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https://doi.org/10.3390/antibiotics9050216 | Antibiotics | 2020 | |
Enhanced Concanavalin A Binding to Preorganized Mannose Nanoarrays in Glycodendrimersomes Revealed Multivalent Interactions
N. Yu. Kostina, D. Söder, T. Haraszti, Q. Xiao, K. Rahimi, B. E. Partridge, M. L. Klein, V. Percec and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/anie.202100400 | Angewandte Chemie International Edition | 2021 | |
Evaluation of Dibenzocyclooctyne and Bicyclononyne Click Reaction on Azido-Functionalized Antifouling Polymer Brushes Via Microspotting
B. Yang, Y. Wang, M. Vorobii, E. Sauter, M. Koenig, R. Kumar, C. Rodriguez-Emmenegger and M. Hirtz
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https://doi.org/10.1002/admi.202102325 | Advanced Materials Interfaces | 2022 |