The Rodriguez-Emmenegger group aims at the development of adaptive biointerfaces and protocells able to interact and direct synthetic and natural systems. Towards this aim, they develop routes to tailor the topology and architecture of synthetic and hybrid macromolecules and program their intermolecular interactions to drive the hierarchical directed self-assembly into interfaces and materials capable to selectively and actively (autonomously) alter their properties to environmental cues —biological and artificial. Furthermore, they investigate, how to achieve superselective interfaces by balancing repellency in aqueous systems with multivalent and cooperative attractive interactions.
The Rodriguez-Emmenegger group strives for translating their basic research into adaptive hemocompatible coatings, antimicrobial wound dressings and diagnostic tools. They are also developing new concepts for cell membrane mimics and protocellular systems capable of communicating with living cells and directing their behavior by the exploitation of biophysical and biochemical actions.
Prof. Dr. César Rodriguez-Emmenegger
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Tackling the Root Cause of Surface-Induced Coagulation: Inhibition of Fxii Activation to Mitigate Coagulation Propagation and Prevent Clotting
L. Witzdam, B. Vosberg, K. Große-Berkenbusch, S. Stoppelkamp, H. P. Wendel and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202300321 | Macromolecular Bioscience | 2023 | |
Synthetic Evolution of a Supramolecular Harpooning Mechanism to Immobilize Vesicles at Antifouling Interfaces
J. Englert, L. Witzdam, D. Söder, M. Garay-Sarmiento, A. Joseph, A. M. Wagner and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/macp.202300306 | Macromolecular Chemistry and Physics | 2023 | |
Self-Assembly of Glycerol-Amphiphilic Janus Dendrimers Amplifies and Indicates Principles for the Selection of Stereochemistry by Biological Membranes
D. Zhang, Q. Xiao, M. Rahimzadeh, M. Liu, C. Rodriguez-Emmenegger, Y. Miyazaki, W. Shinoda and V. Percec
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https://doi.org/10.1021/jacs.3c00389 | Journal of the American Chemical Society | 2023 | |
Green Solvent-Based Antifouling Polymer Brushes Demonstrate Excellent Hemocompatibility
J. Englert, M. Palà, L. Witzdam, F. Rayatdoost, O. Grottke, G. Lligadas and C. Rodriguez-Emmenegger
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https://doi.org/10.1021/acs.langmuir.3c02765 | Langmuir | 2023 | |
Glycan-Driven Formation of Raft-Like Domains with Hierarchical Periodic Nanoarrays on Dendrimersome Synthetic Cells
A. M. Wagner, N. Y. Kostina, Q. Xiao, M. L. Klein, V. Percec and C. Rodriguez-Emmenegger
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https://doi.org/10.1021/acs.biomac.3c01027 | Biomacromolecules | 2023 | |
Brush-Like Coatings Provide a Cloak of Invisibility to Titanium Implants
L. Witzdam, M. Garay-Sarmiento, M. Gagliardi, Y. L. Meurer, Y. Rutsch, J. Englert, S. Philipsen, A. Janem, R. Alsheghri, F. Jakob, D. G. M. Molin, U. Schwaneberg, N. M. S. van den Akker and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202300434 | Macromolecular Bioscience | 2023 | |
Zwitterionic Dendrimersomes: A Closer Xenobiotic Mimic of Cell Membranes
A. Joseph, A. M. Wagner, M. Garay-Sarmiento, M. Aleksanyan, T. Haraszti, D. Söder, V. N. Georgiev, R. Dimova, V. Percec and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/adma.202206288 | Advanced Materials | 2022 | |
The Relation between Protein Adsorption and Hemocompatibility of Antifouling Polymer Brushes
Z. Riedelová, A. de los Santos Pereira, J. Svoboda, O. Pop-Georgievski, P. Májek, K. Pečánková, F. Dyčka, C. Rodriguez-Emmenegger and T. Riedel
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https://doi.org/10.1002/mabi.202200247 | Macromolecular Bioscience | 2022 | |
Ionic Combisomes: A New Class of Biomimetic Vesicles to Fuse with Life
A. M. Wagner, J. Quandt, D. Söder, M. Garay-Sarmiento, A. Joseph, V. S. Petrovskii, L. Witzdam, T. Hammoor, P. Steitz, T. Haraszti, I. I. Potemkin, N. Y. Kostina, A. Herrmann and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/advs.202200617 | Advanced Science | 2022 | |
Interactive Hemocompatible Nanocoating to Prevent Surface-Induced Coagulation in Medical Devices
J. Quandt, M. Garay-Sarmiento, L. Witzdam, J. Englert, Y. Rutsch, C. Stöcker, F. Obstals, O. Grottke and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/admi.202201055 | Advanced Materials Interfaces | 2022 | |
Globular Hydrophilic Poly(acrylate)s by an Arborescent Grafting-from Synthesis
J. Robin Höhner, Rustam A. Gumerov, Igor I. Potemkin, César Rodriguez-Emmenegger, Nina Yu. Kostina, Ahmed Mourran, Jenny Englert, David Schröter, Lennart Janke, and Martin Möller
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https://doi.org/10.1021/acs.macromol.1c02548 | Macromolecules | 2022 | |
Evaluation of Dibenzocyclooctyne and Bicyclononyne Click Reaction on Azido-Functionalized Antifouling Polymer Brushes Via Microspotting
B. Yang, Y. Wang, M. Vorobii, E. Sauter, M. Koenig, R. Kumar, C. Rodriguez-Emmenegger and M. Hirtz
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https://doi.org/10.1002/admi.202102325 | Advanced Materials Interfaces | 2022 |