The research of our group focuses on synthetic chemistry and molecular biology. Chemists, biologists and physicists are dedicated to the task of inventing new molecular technologies to create new (bio)molecular and biohybrid structures by combining chemical and biological processes. Our group has pioneered the development of two classes of materials: nucleic acid polymer conjugates and supercharged polypeptides. Inspired by nature, these materials are designed to form well-defined molecular architectures that span multiple length scales from nanometer to macroscopic structures. These structures are key for the realization of complex functions in technological, medical and life science applications.
Sonopharmacology: Our group was the first to transfer concepts from polymer mechanochemistry to the life sciences. Ultrasound and the resulting shear forces in aqueous environment act as external trigger to activate different classes of drug molecules realizing a novel concept for precision targeting medicines.
D. Yiliz, R. Göstl & A. Herrmann: Chem. Sci. 2022, 13: 13708-13719
S. Huo et al.: Nat. Chem. 2021, 13: 131-139
Sonogenetics: Besides switching on active pharmaceutical ingredients by ultrasound, we exploit this trigger to manipulate the activity of proteins and genes. Enzymes and nucleic acids are designed to respond to low intensity biocompatible ultrasound to remotely orchestrate biological systems deep inside the body in the future.
J. Hahmann et al.: Angew. Chem. Int. Ed. 2024, e202317112
P. Zhao et al.: Angew. Chem. Int. Ed. 2021, 60(26): 14707-14714
Ultrastrong Bioadhesives: We design molecular glues de novo by exploiting recombinant protein expression and genetic engineering. Supercharged polypeptides were complexed with surfactants to form coacervate-based adhesives with outstanding features such as temperature switchability, hemostatic and wound healing promoting properties.
Y. Zhou et al.: Adv. Mater. 2023, 35(16): 2210052
C. Ma et al.: Nat. Commun. 2021, 12: 3613
Prof. Dr. Andreas Herrmann
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Activation of Antibiotic-Grafted Polymer Brushes by Ultrasound
M. Zou, P. Zhao, S. Huo, R. Göstl and A. Herrmann
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https://doi.org/10.1021/acsmacrolett.1c00645 | ACS Macro Letters | 2021 | |
Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound
P. Zhao, S. Huo, J. Fan, J. Chen, F. Kiessling, A. J. Boersma, R. Göstl and A. Herrmann
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https://doi.org/10.1002/anie.202105404 | Angewandte Chemie International Edition | 2021 | |
An Optimized Sensor Array Identifies All Natural Amino Acids
B. H. Wang, J. S. Han, N. M. Bojanowski, M. Bender, C. Ma, K. Seehafer, A. Herrmann and U. H. F. Bunz
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https://www.doi.org/10.1021/acssensors.8b00371 | Acs Sensors | 2018 | |
Animal Fiber Identification under the Open Set Condition
O. Rippel, S. Gülçelik, K. Rahimi, J. Kurniadi, A. Herrmann, D. Merhof
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https://doi.org/10.5220/0010769800003124 | Proceedings of the 17th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications | 2022 | |
Anti-Stokes Stress Sensing: Mechanochemical Activation of Triplet-Triplet Annihilation Photon Upconversion
D. Yildiz, C. Baumann, A. Mikosch, A. J. C. Kuehne, A. Herrmann and R. Göstl
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https://www.doi.org/10.1002/anie.201907436 | Angew Chem Int Ed Engl | 2019 | |
Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B
A. A. Bastian, A. Gruszka, P. Jung and A. Herrmann
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https://doi.org/10.1039/D0OB02104K | Organic & Biomolecular Chemistry | 2020 | |
Artificial Phase-Transitional Underwater Bioglue with Robust and Switchable Adhesion Performance
L. Xiao, Z. Wang, Y. Sun, B. Li, B. Wu, C. Ma, V. S. Petrovskii, X. Gu, D. Chen, I. I. Potemkin, A. Herrmann, H. Zhang and K. Liu
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https://doi.org/10.1002/anie.202102158 | Angewandte Chemie International Edition | 2021 | |
Assessing the NLRP3 Inflammasome Activating Potential of a Large Panel of Micro- and Nanoplastics in THP-1 Cells
M. Busch, G. Bredeck, F. Waag, K. Rahimi, H. Ramachandran, T. Bessel, S. Barcikowski, A. Herrmann, A. Rossi and R. P. F. Schins
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https://doi.org/10.3390/biom12081095 | Biomolecules | 2022 | |
Bedeutung Von Makromolekülen Im Kampf Gegen Das Coronavirus
J. Köhler, A. Thoma, S. Braun, A. Pich and A. Herrmann
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https://doi.org/10.1002/ciuz.202100024 | Chemie in unserer Zeit | 2021 | |
Biochemical and Structural Insight into the Chemical Resistance and Cofactor Specificity of the Formate Dehydrogenase from Starkeya Novella
M. Partipilo, J. J. Whittaker, N. Pontillo, J. Coenradij, A. Herrmann, A. Guskov and D. J. Slotboom
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https://doi.org/10.1111/febs.16871 | The FEBS Journal | 2023 | |
Brimonidine loaded lipid DNA-nanoparticles as an improved and novel treatment option for glaucoma
S. Schnichels, K. Frossl, J. W. de Vries, M. Loscher, K. Bartz-Schmidt, A. Herrmann, M. S. Spitzer and J. Hurst
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Investigative Ophthalmology & Visual Science | 2019 | ||
Carrier-Free Micellar Cpg Interacting with Cell Membrane for Enhanced Immunological Treatment of Hiv-1
H. Kim, W. Zhang, J. Hwang, E.-K. An, Y. K. Choi, E. Moon, M. Loznik, Y. H. Huh, A. Herrmann, M. Kwak and J.-O. Jin
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https://doi.org/10.1016/j.biomaterials.2021.121081 | Biomaterials | 2021 |