The expertise of the Schwaneberg group lies in protein engineering by directed evolution and rational design. Directed evolution methodologies were awarded with the Nobel Prize in chemistry in 2018 and workgroup Schwaneberg is ranked 3rd in respect to published manuscripts (Web of Science; search term “directed evolution”). Research is organized in 5 divisions with the general goal to advance directed evolution methodologies, to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties.
Prof. Dr. Ulrich Schwaneberg
Team
Projects
Publications
Titel/Autoren | DOI-LINK | Magazine | Jahre | |
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Bifunctional Peptides as Alternatives to Copper-Based Formulations to Control Citrus Canker
G. Dilarri, L. C. de Lencastre Novaes, F. Jakob, U. Schwaneberg and H. Ferreira
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https://doi.org/10.1007/s00253-023-12908-3 | Applied Microbiology and Biotechnology | 2024 | |
A Competitive High-Throughput Screening Platform for Designing Polylactic Acid-Specific Binding Peptides
Y. Lu, K.-W. Hintzen, T. Kurkina, Y. Ji and U. Schwaneberg
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https://doi.org/10.1002/advs.202303195 | Advanced Science | 2023 | |
A Flow Cytometry-Based Ultrahigh-Throughput Screening Method for Directed Evolution of Oxidases
L. Feng, L. Gao, V. Besirlioglu, K. Essani, M. Wittwer, T. Kurkina, Y. Ji and U. Schwaneberg
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https://doi.org/10.1002/anie.202214999 | Angewandte Chemie International Edition | 2023 | |
A Phylogeny-Based Directed Evolution Approach to Boost the Synthetic Applications of Glycosyltransferases
P. Zhang, Y. Ji, S. Meng, Z. Li, D. Hirtz, L. Elling and U. Schwaneberg
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https://doi.org/10.1039/D3GC01259J | Green Chemistry | 2023 | |
A Step Forward to the Optimized Hlya Type 1 Secretion System through Directed Evolution
Z. N. Pourhassan, H. Cui, N. Muckhoff, M. D. Davari, S. H. J. Smits, U. Schwaneberg and L. Schmitt
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https://doi.org/10.1007/s00253-023-12653-7 | Applied Microbiology and Biotechnology | 2023 | |
Brush-Like Coatings Provide a Cloak of Invisibility to Titanium Implants
L. Witzdam, M. Garay-Sarmiento, M. Gagliardi, Y. L. Meurer, Y. Rutsch, J. Englert, S. Philipsen, A. Janem, R. Alsheghri, F. Jakob, D. G. M. Molin, U. Schwaneberg, N. M. S. van den Akker and C. Rodriguez-Emmenegger
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https://doi.org/10.1002/mabi.202300434 | Macromolecular Bioscience | 2023 | |
Commentary: Polymer Binding Modules Accelerate Enzymatic Degradation of Poly(Ethylene Terephthalate)
Y. Lu, R. Han, U. Schwaneberg and Y. Ji
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https://doi.org/10.13345/j.cjb.221033 | Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology | 2023 | |
Deep Learning Guided Enzyme Engineering of Thermobifida Fusca Cutinase for Increased Pet Depolymerization
S. Meng, Z. Li, P. Zhang, F. Contreras, Y. Ji and U. Schwaneberg
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https://doi.org/10.1016/S1872-2067(23)64470-5 | Chinese Journal of Catalysis | 2023 | |
Directed Evolution of Material Binding Peptide for Polylactic Acid-Specific Degradation in Mixed Plastic Wastes
Y. Lu, K.-W. Hintzen, T. Kurkina, Y. Ji and U. Schwaneberg
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https://doi.org/10.1021/acscatal.3c02142 | ACS Catalysis | 2023 | |
Empowering Site-Specific Bioconjugations in Vitro and in Vivo: Advances in Sortase Engineering and Sortase-Mediated Ligation
Z. Zou, Y. Ji and U. Schwaneberg
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https://doi.org/10.1002/anie.202310910 | Angewandte Chemie International Edition | 2023 | |
Engineering All-Round Cellulase for Bioethanol Production
M. Wang, H. Cui, C. Gu, A. Li, J. Qiao, U. Schwaneberg, L. Zhang, J. Wei, X. Li and H. Huang
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https://doi.org/10.1021/acssynbio.3c00289 | ACS Synthetic Biology | 2023 | |
Engineering of Substrate Tunnel of P450 Cyp116b3 Though Machine Learning
Y. Liu, Z. Li, C. Cao, X. Zhang, S. Meng, M. D. Davari, H. Xu, Y. Ji, U. Schwaneberg and L. Liu
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https://doi.org/10.3390/catal13081228 | Catalysts | 2023 |